Batch processes in the biopharmaceutical and chemical manufacturing industries often develop new products to meet changing market demands. When the dynamic models of these new products are trained, dynamic modeling with limited data for each product can lead to inaccurate results. One solution is to extract useful knowledge from past historical production data that can be applied to the product of a new grade. In this way, the model can be built quickly without having to wait for additional modeling data. In this study, a subspace identification combined common feature learning scheme is proposed to quickly learn a model of a new grade. The proposed modified state-space model contains common and special parameter matrices. Past batch data can be used to train common parameter matrices. Then, the parameters can be directly transferred into a new SID model for a new grade of the product. The new SID model can be quickly well trained even though there is a limited batch of data. The effec... [more]

Support vector data description (SVDD) has been widely applied to batch process fault detection. However, it often performs poorly, especially when incipient faults occur, because it only considers the shallow data feature and omits the probabilistic information of features. In order to provide better monitoring performance on incipient faults in batch processes, an improved SVDD method, called deep probabilistic SVDD (DPSVDD), is proposed in this work by integrating the convolutional autoencoder and the probability-related monitoring indices. For mining the hidden data features effectively, a deep convolutional features extraction network is designed by a convolutional autoencoder, where the encoder outputs and the reconstruction errors are used as the monitor features. Furthermore, the probability distribution changes of these features are evaluated by the Kullback-Leibler (KL) divergence so that the probability-related monitoring indices are developed for indicating the process stat... [more]

In this paper, a two-dimensional, two-layer quality regression model is established to monitor multi-phase, multi-mode batch processes. Firstly, aiming at the multi-phase problem and the multi-mode problem simultaneously, the relations among modes and phases are captured through the analysis between process variables and quality variables by establishing a two-dimensional, two-layer regression partial least squares (PLS) model. The two-dimensional regression traces the intra-batch and inter-batch characteristics, while the two-layer structure establishes the relationship between the target process and historical modes and phases. Consequently, online monitoring is carried out for multi-phase, multi-mode batch processes based on quality prediction. In addition, the online quality prediction and monitoring results based on the proposed method and those based on the traditional phase mean PLS method are compared to prove the effectiveness of the proposed method.

Safe and stable operation plays an important role in the chemical industry. Fault detection and diagnosis (FDD) make it possible to identify abnormal process deviations early and assist operators in taking proper action against fault propagation. After decades of development, data-driven process monitoring technologies have gradually attracted attention from process industries. Although many promising FDD methods have been proposed from both academia and industry, challenges remain due to the complex characteristics of industrial data. In this work, classical and recent research on data-driven process monitoring methods is reviewed from the perspective of characterizing and mining industrial data. The implementation framework of data-driven process monitoring methods is first introduced. State of art of process monitoring methods corresponding to common industrial data characteristics are then reviewed. Finally, the challenges and possible solutions for actual industrial applications a... [more]

Biosorption has great potential in removing toxic effluents from wastewater, especially heavy metal ions such as cobalt, lead, copper, mercury, cadmium, nickel and other ions. Mathematically modeling of biosorption process is essential for the economical and robust design of equipment employing the bioadsorption process. However, biosorption is a complex physicochemical process involving various transport and equilibrium processes, such as absorption, adsorption, ion exchange and surface and interfacial phenomena. The biosorption process becomes even more complex in cases of multicomponent systems and needs an extensive parametric analysis to develop a mathematical model in order to quantify metal ion recovery and the performance of the process. The biosorption process involves various process parameters, such as concentration, contact time, pH, charge, porosity, pore size, available sites, velocity and coefficients, related to activity, diffusion and dispersion. In this review paper,... [more]

To obtain quality variables that cannot be measured in real time during the production process but reflect information on the quality of the final product, the batch production process has the characteristics of a strong time-varying nature, non-Gaussian data distribution and high nonlinearity. A locally weighted partial least squares regression quality prediction model (KICA-JITL-LWPLS), based on wavelet kernel function independent meta-analysis with immediate learning, is proposed. The model first measures the similarity between the normalized input data and the historical data and assigns the input data to the group of historical data with high similarity to it, based on the posterior probability of the Bayesian classifier; subsequently, wavelet kernel functions are selected and kernel learning methods are introduced into the independent meta-analysis algorithm. An independent meta-analysis, based on the wavelet kernel function, is performed on the classified input data to obtain pr... [more]

By-products of laying hens represent a promising raw material source with a high collagen content, which is currently not adequately used. The aim of the paper is to prepare gelatins from laying hen paws. The purified collagen raw material was processed by a biotechnological process using the food endoprotease Protamex®. After cleavage of the cross-links in the collagen structure, the gelatin was extracted by a batch process with a stirrer in two extraction steps. The influence of the extraction process on the yield of gelatins and on selected qualitative parameters of gelatins was monitored by two-level factor experiments with three selected process factors. The studied factors were: enzyme dosage (0.2−0.8%), enzyme processing time (24−72 h) and gelatin extraction time (30−120 min). After the first extraction step at 75 °C, gelatin was extracted with a yield of 8.2−21.4% and a gel strength of 275−380 Bloom. In the second extraction step at 80−100 °C, it is possible to obtain another p... [more]

The problem of scheduling multiproduct and multipurpose batch processes has been studied for more than 30 years using math programming and heuristics. In most formulations, the manufacturing recipes are represented by simplified models using state task network (STN) or resource task network (RTN), transfers of materials are assumed to be instantaneous, constraints due to shared utilities are often ignored, and scheduling horizons are kept small due to the limits on the problem size that can be handled by the solvers. These limitations often result in schedules that are not actionable. A simulation model, on the other hand, can represent a manufacturing recipe to the smallest level of detail. In addition, a simulator can provide a variety of built-in capabilities that model the assignment decisions, coordination logic and plant operation rules. The simulation based schedules are more realistic, verifiable, easy to adapt for changing plant conditions and can be generated in a short perio... [more]

A phenomenological model was developed to describe the dynamic evolution of the batch suspension polymerization of methyl methacrylate in terms of reactor temperature, pressure, concentrations and molecular properties of the final polymer. Then, the phenomenological model was used as a process constraint in dynamic data reconciliation procedures, which allowed for the successful monitoring of reaction variables in real-time and on-line. The obtained results indicate that heat transfer coefficients change significantly during the reaction time and from batch to batch, exerting a tremendous impact on the process operation. Obtained results also indicate that it can be difficult to attain thermodynamic equilibrium conditions in this system, because of the continuous condensation of evaporated monomer and the large mass transfer resistance offered by the viscous suspended droplets.