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Records with Subject: Process Operations
Showing records 626 to 650 of 716. [First] Page: 22 23 24 25 26 27 28 29 Last
Near-Null Geomagnetic Field as an Innovative Method of Fruit Storage
Grzegorz Zaguła, Maria Tarapatskyy, Marcin Bajcar, Bogdan Saletnik, Czesław Puchalski, Andrzej Marczuk, Dariusz Andrejko, Jan Oszmiański
May 2, 2020 (v1)
Keywords: apples storage, chemical profile, compensation, geomagnetic field, sugars
The article presents the findings of a study investigating the effects of storing Jonagold apples for six weeks in a condition in which the vertical component of the geomagnetic field has been eliminated (near null GMF) and in control conditions representing those applied in traditional storage (i.e., in the local geomagnetic field (local GMF)). Analyses of the fruit were performed before the start of and three times during the experiment (i.e., following four, five and six weeks in storage). The contents of simple sugars were measured using the HPLC (high performance liquid chromatography) method; refractometry was applied to identify total extract; thermogravimetry was used to measure the water content, volatile substances and total ash; calorific value and intensity of respiration were examined by measuring CO2 emissions. Significant differences were found between the apples stored in the experimental and under control conditions, showing an advantage of storage in a condition with... [more]
Theoretical and Experimental Studies of a Digital Flow Booster Operating at High Pressures and Flow Rates
Chenggang Yuan, Vinrea Lim Mao Lung, Andrew Plummer, Min Pan
April 14, 2020 (v1)
Keywords: digital hydraulics, efficient fluid power, flow booster, high-speed switching valves, pressure booster, switched inertance hydraulic systems
The switched inertance hydraulic converter (SIHC) is a new technology providing an alternative to conventional proportional or servo-valve-controlled systems in the area of fluid power. SIHCs can adjust or control flow and pressure by means of using digital control signals that do not rely on throttling the flow and dissipation of power, and provide hydraulic systems with high-energy efficiency, flexible control, and insensitivity to contamination. In this article, the analytical models of an SIHC in a three-port flow-booster configuration were used and validated at high operating pressure, with the low- and high-pressure supplies of 30 and 90 bar and a high delivery flow rate of 21 L/min. The system dynamics, flow responses, and power consumption were investigated and theoretically and experimentally validated. Results were compared to previous results achieved using low operating pressures, where low- and high-pressure supplies were 20 and 30 bar, and the delivery flow rate was 7 L/m... [more]
Quantifying the Benefit of a Dynamic Performance Assessment of WWTP
Silvana Revollar, Montse Meneses, Ramón Vilanova, Pastora Vega, Mario Francisco
April 14, 2020 (v1)
Keywords: dynamic assessment of performance, environmental costs, PID control, wastewater treatment plants
In this work a comprehensive analysis of the environmental impact of the operation of a wastewater treatment plant (WWTP) using different control strategies is carried out considering the dynamic evolution of some environmental indicators and average operation costs. The selected strategies are PI (proportional integral) control schemes such as dissolved oxygen control in the aerobic zone (DO control), DO control and nitrates control in the anoxic zone (DO + NO control) and regulation of ammonium control at the end of aerobic zone (Cascade SNHSP) commonly used in WWTPs to maintain the conditions that ensure the desired effluent quality in a variable influent scenario. The main novelty of the work is the integration of potential insights into environmental impact from the analysis of dynamic evolution of environmental indicators at different time scales. The consideration of annual, bimonthly and weekly temporal windows to evaluate performance indicators makes it possible to capture sea... [more]
A Retrofit Hierarchical Architecture for Real-Time Optimization and Control Integration
Xiaochen Li, Lei Xie, Xiang Li, Hongye Su
April 1, 2020 (v1)
Keywords: extremum-seeking control, hierarchical architecture, least-squares regression, necessary conditions of optimality, optimal operation, self-optimizing control
To achieve the optimal operation of chemical processes in the presence of disturbances and uncertainty, a retrofit hierarchical architecture (HA) integrating real-time optimization (RTO) and control was proposed. The proposed architecture features two main components. The first is a fast extremum-seeking control (ESC) approach using transient measurements that is employed in the upper RTO layer. The fast ESC approach can effectively suppress the impact of plant-model mismatch and steady-state wait time. The second is a global self-optimizing control (SOC) scheme that is introduced to integrate the RTO and control layers. The proposed SOC scheme minimizes the global average loss based on the approximation of necessary conditions of optimality (NCO) over the entire operating region. A least-squares regression technique was adopted to select the controlled variables (CVs) as linear combinations of measurements. The proposed method does not require the second order derivative information,... [more]
Investigation of the Most Suitable Conditions for Dehydration of Tuckeroo (Cupaniopsis anacardioides) Fruits
Ngoc Minh Quynh Pham, Quan V. Vuong, Anh V. Le, Michael C. Bowyer, Christopher J. Scarlett
March 12, 2020 (v1)
Keywords: antioxidant, dehydration, drying, fruit, phytochemical, Tuckeroo
Tuckeroo (Cupaniopsis anacardioides) is an Australian native tree, possessing high level bioactivity and antioxidant activity. To prevent deterioration of active constituents, appropriate drying practices must be determined. This study comparatively evaluates the impact of a range of drying methods including freeze-, microwave-, vacuum-, hot air- and sun-drying on the physical, phytochemical and antioxidant characteristics of Tuckeroo fruit. Experimental results showed that the five drying methods had significant impact on the physicochemical properties and antioxidant activity of the fruits. Of the drying methods assessed, freeze drying best preserved Tuckeroo activity, recording higher total phenolic content (TPC) (81.88 mg gallic acid equivalent (GAE)/g), total flavonoids (TFC) (107.71 mg catechin equivalent (CAE)/g), proanthocyanidins (TPro) (83.86 mg CAE/g) and exhibited the strongest antioxidant capacity. However, vacuum drying at 65 kPa, 100 °C for 5 h is recommended for drying... [more]
Quality Control for Medium Voltage Insulator via a Knowledge-Informed SPSA Based on Historical Gradient Approximations
Xiangsong Kong, Jiaming Guo, Dongbin Zheng, Ji Zhang, Wei Fu
March 11, 2020 (v1)
Keywords: historical gradient approximations, knowledge-informed, medium voltage insulator, quality control, SPSA
Medium voltage insulators are essential and versatile components in electrical engineering. Quality control of the manufacturing process for the insulators has a significant role in their economic production and reliable operation. As the quality of medium voltage insulator is mainly affected by the process parameters of the automatic pressure gelation process (APG), the optimal process settings are required to achieve a satisfactory quality target. However, traditional process parameters’ optimization methods are often cumbersome and cost-consuming. Moreover, the operational cost of APG for insulator production is relatively high. Therefore, the determination of the optimal settings becomes a significant challenge for the quality control of insulators. To address the above issues, an idea of knowledge-informed optimization was proposed in this study. Based on the above idea, a knowledge-informed simultaneous perturbation stochastic approximation (SPSA) methodology was formulated to re... [more]
Influence of Eccentricity on Hydrodynamic Characteristics of Nuclear Reactor Coolant Pump under Different Cavitation Conditions
Yuanyuan Zhao, Bin Lin, Xiuli Wang, Rongsheng Zhu, Qiang Fu
February 12, 2020 (v1)
Keywords: axial force, cavitation, eccentricity, nuclear reactor coolant pump, radial force
In order to study the influence of eccentricity on hydrodynamic characteristics of nuclear reactor coolant pump under different cavitation conditions, five different schemes were obtained by analyzing and optimizing the existing structural schemes. Based on the RNG k-ε model (Renormalization Group with k-epsilon turbulence models) and two-fluid two-phase flow model, the unsteady numerical analysis and test verification of different designed schemes are carried out by using the flow field software ANSYS CFX. The results of research show that different eccentricities will affect the nuclear reactor coolant pump’s head under different cavitation conditions, and the corresponding head in the scheme with the eccentricity of 5mm under the fracture cavitation condition is lower than that of the other schemes. When the impeller rotates at a certain angle from the initial position under critical and severe cavitation conditions, the radial force acting on the rotor system will fluctuate greatly... [more]
Modeling, Simulation, and Operability Analysis of a Nonisothermal, Countercurrent, Polymer Membrane Reactor
Brent A. Bishop, Fernando V. Lima
February 12, 2020 (v1)
Keywords: modularity, operability, Process Intensification, process modeling and simulation
As interest in the modularization and intensification of chemical processes continues to grow, more research must be directed towards the modeling and analysis of these units. Intensified process units such as polymer membrane reactors pose unique challenges pertaining to design and operation that have not been fully addressed. In this work, a novel approach for modeling membrane reactors is developed in AVEVA’s Simcentral Simulation Platform. The produced model allows for the simulation of polymer membrane reactors under nonisothermal and countercurrent operation for the first time. This model is then applied to generate an operability mapping to study how operating points translate to overall unit performance. This work demonstrates how operability analyses can be used to identify areas of improvement in membrane reactor design, other than just using operability mapping studies to identify optimal input conditions. The performed analysis enables the quantification of the Pareto front... [more]
Multimode Operating Performance Visualization and Nonoptimal Cause Identification
Yuhui Ying, Zhi Li, Minglei Yang, Wenli Du
February 3, 2020 (v1)
Keywords: multi-space principal component analysis, multimode process, performance assessment, self-organizing map, subtractive clustering
In the traditional performance assessment method, different modes of data are classified mainly by expert knowledge. Thus, human interference is highly probable. The traditional method is also incapable of distinguishing transition data from steady-state data, which reduces the accuracy of the monitor model. To solve these problems, this paper proposes a method of multimode operating performance visualization and nonoptimal cause identification. First, multimode data identification is realized by subtractive clustering algorithm (SCA), which can reduce human influence and eliminate transition data. Then, the multi-space principal component analysis (MsPCA) is used to characterize the independent characteristics of different datasets, which enhances the robustness of the model with respect to the performance of independent variables. Furthermore, a self-organizing map (SOM) is used to train these characteristics and map them into a two-dimensional plane, by which the visualization of th... [more]
A Hybrid Data-Based and Model-Based Approach to Process Monitoring and Control in Sheet Metal Forming
Sravan Tatipala, Johan Wall, Christian Johansson, Tobias Larsson
February 3, 2020 (v1)
Keywords: in-line measurement data, Industry 4.0, modelling and simulation, process monitoring and control, process performance, product quality, sheet metal forming
The ability to predict and control the outcome of the sheet metal forming process demands holistic knowledge of the product/process parameter influences and their contribution in shaping the output product quality. Recent improvements in the ability to harvest in-line production data and the increased capability to understand complex process behaviour through computer simulations open up the possibility for new approaches to monitor and control production process performance and output product quality. This research presents an overview of the common process monitoring and control approaches while highlighting their limitations in handling the dynamics of the sheet metal forming process. The current paper envisions the need for a collaborative monitoring and control system for enhancing production process performance. Such a system must incorporate comprehensive knowledge regarding process behaviour and parameter influences in addition to the current-system-state derived using in-line... [more]
Investigating the In-Flow Characteristics of Multi-Operation Conditions of Cross-Flow Fan in Air Conditioning Systems
Weijie Zhang, Jianping Yuan, Qiaorui Si, Yanxia Fu
January 19, 2020 (v1)
Keywords: cross-flow fan, internal flow, multi-operating condition, pressure fluctuation, the aerodynamic noise
Cross-flow fans are widely used in numerous applications such as low-pressure ventilation, household appliances, laser instruments, and air-conditioning equipment. Cross-flow fans have superior characteristics, including simple structure, small size, stable airflow, high dynamic pressure coefficient, and low noise. In the present study, numerical simulation and experimental research were carried out to study the unique secondary flow and eccentric vortex flow characteristics of the internal flow field in multi-operating conditions. To this end the vorticity and the circumferential pressure distribution in the air duct are obtained based on the performed experiments and the correlation between spectral characteristics of multiple operating conditions and the inflow state is established. The obtained results show that when the area of the airflow passage decreases while the area of the eccentric vortex area gradually increases, then the airflow of the cross-flow fan decreases, the outlet... [more]
A Graphical Model to Diagnose Product Defects with Partially Shuffled Equipment Data
Gilseung Ahn, Sun Hur, Dongmin Shin, You-Jin Park
January 19, 2020 (v1)
Keywords: defect diagnosis, equipment data analysis, graphical model, multi-source data fusion, partially shuffled time series
The diagnosis of product defects is an important task in manufacturing, and machine learning-based approaches have attracted interest from both the industry and academia. A high-quality dataset is necessary to develop a machine learning model, but the manufacturing industry faces several data-collection issues including partially shuffled data, which arises when a product ID is not perfectly inferred and yields an unstable machine learning model. This paper introduces latent variables to formulate a supervised learning model that addresses the problem of partially shuffled data. The experimental results show that our graphical model deals with the shuffling of product order and can detect a defective product far more effectively than a model that ignores shuffling.
ELM-Based AFL−SLFN Modeling and Multiscale Model-Modification Strategy for Online Prediction
Xiaoli Wang, He Zhang, Yalin Wang, Shaoming Yang
January 6, 2020 (v1)
Keywords: adaptive hybrid modeling, extreme learning machine, multiscale modification strategy
Online prediction of key parameters (e.g., process indices) is essential in many industrial processes because online measurement is not available. Data-based modeling is widely used for parameter prediction. However, model mismatch usually occurs owing to the variation of the feed properties, which changes the process dynamics. The current neural network online prediction models usually use fixed activation functions, and it is not easy to perform dynamic modification. Therefore, a few methods are proposed here. Firstly, an extreme learning machine (ELM)-based single-layer feedforward neural network with activation-function learning (AFL−SLFN) is proposed. The activation functions of the ELM are adjusted to enhance the ELM network structure and accuracy. Then, a hybrid model with adaptive weights is established by using the AFL−SLFN as a sub-model, which improves the prediction accuracy. To track the process dynamics and maintain the generalization ability of the model, a multiscale mo... [more]
Performance Assessment of a Hybrid Vapor Compression and Evaporative Cooling Fresh-Air-Handling Unit Operating in Hot Climates
Yousef Al Horr, Bourhan Tashtoush, Nelson Chilengwe, Mohamed Musthafa
January 2, 2020 (v1)
Keywords: cooling performance, energy savings, hot and humid climate, indirect evaporative cooling, mode of operation
Evaporative cooling can be integrated into fresh-air-handling units, to reduce cooling demand. This study considers a hybrid fresh-air-handling unit which incorporates a vapor-compression cooling cycle and indirect evaporative cooling to condition an ambient primary airstream to a desired supply air state. The cooling effects of using various modes (vapor compression only; direct expansion with mist; direct expansion with water shower; and direct expansion with mist and water shower) are compared when the fresh-air-handling unit operates in harsh (hot and humid) climatic conditions experienced in Qatar. Experimental analysis is based on actual ambient conditions measured from August 2018 to July 2019. It is found that the best-performing wet mode of operation saves more than 60% of the energy required by a conventional direct expansion cooling system operating under the same ambient conditions. In hot, dry conditions, the coefficient of performance of the fresh-air-handling unit when u... [more]
Performance Evaluation Using Multivariate Non-Normal Process Capability
Moath Alatefi, Shafiq Ahmad, Mohammed Alkahtani
December 16, 2019 (v1)
Keywords: multivariate, non-normal data, process capability index, transformation techniques
Process capability indices (PCIs) have always been used to improve the quality of products and services. Traditional PCIs are based on the assumption that the data obtained from the quality characteristic (QC) under consideration are normally distributed. However, most data on manufacturing processes violate this assumption. Furthermore, the products and services of the manufacturing industry usually have more than one QC; these QCs are functionally correlated and, thus, should be evaluated together to evaluate the overall quality of a product. This study investigates and extends the existing multivariate non-normal PCIs. First, a multivariate non-normal PCI model from the literature is modeled and validated. An algorithm to generate non-normal multivariate data with the desired correlations is also modeled. Then, this model is extended using two different approaches that depend on the well-known Box−Cox and Johnson transformations. The skewness reduction is further improved by applyin... [more]
Natural Frequency Sensitivity Analysis of Fire-Fighting Jet System with Adaptive Gun Head
Xiaoming Yuan, Xuan Zhu, Chu Wang, Lijie Zhang, Yong Zhu
December 13, 2019 (v1)
Keywords: adaptive gun head, flow control, jet system, mode shape, natural frequency, sensitivity analysis
The gun head is the end effector of the fire-fighting jet system. Compared with a traditional fixed gun head, an adaptive gun head has the advantages of having an adjustable nozzle opening, a wide applicable flow range, and a high fire-extinguishing efficiency. Thus, the adaptive gun head can extinguish large fires quickly and efficiently. The fire-fighting jet system with an adaptive gun head has fluid-structure interaction and discrete-continuous coupling characteristics, and the influence of key design parameters on its natural frequencies needs to be determined by a sensitivity analysis. In this paper, the dynamic model and equations of the jet system were established based on the lumped parameter method, and the sensitivity calculation formulas of the natural frequency of the jet system to typical design parameters were derived. Natural frequencies and mode shapes of the jet system were determined based on a mode analysis. The variation law of the sensitivity of the natural freque... [more]
Technical Assessment of Different Operating Conditions of an On-Board Autothermal Reformer for Fuel Cell Vehicles
Laura Tribioli, Raffaello Cozzolino, Daniele Chiappini
December 10, 2019 (v1)
Keywords: fuel cell vehicle, high temperature proton exchange membrane (PEM) fuel cell, hydrocarbons autothermal reforming, on-board hydrogen production
This paper evaluates the performance of a fuel cell/battery vehicle with an on-board autothermal reformer, fed by different liquid and gaseous hydrocarbon fuels. A sensitivity analysis is performed to investigate the system behavior under the variation of the steam to carbon and oxygen to carbon ratios. This is done in order to identify the most suitable operating conditions for a direct on-board production of hydrogen to be used in a high temperature polymer electrolyte membrane fuel cell. The same system should be able to process different fuels, to allow the end-user to freely decide which one to use to refuel the vehicle. Hence, the obtained operating conditions result in a trade-off between system flexibility as the feeding fuel changes, CO poisoning effect on the fuel cell and overall efficiency. The system is thus coupled to a high temperature fuel cell, modeled by means of a self-made tool, able to reproduce the polarization curve as the input syngas composition varies, and the... [more]
Effect of Fuel Injection Strategy on the Carbonaceous Structure Formation and Nanoparticle Emission in a DISI Engine Fuelled with Butanol
Simona Silvia Merola, Adrian Irimescu, Silvana Di Iorio, Bianca Maria Vaglieco
December 10, 2019 (v1)
Keywords: Butanol, direct injection, Gasoline, nanoparticle emissions, optical investigations, spark ignition engine
Within the context of ever wider expansion of direct injection in spark ignition engines, this investigation was aimed at improved understanding of the correlation between fuel injection strategy and emission of nanoparticles. Measurements performed on a wall guided engine allowed identifying the mechanisms involved in the formation of carbonaceous structures during combustion and their evolution in the exhaust line. In-cylinder pressure was recorded in combination with cycle-resolved flame imaging, gaseous emissions and particle size distribution. This complete characterization was performed at three injection phasing settings, with butanol and commercial gasoline. Optical accessibility from below the combustion chamber allowed visualization of diffusive flames induced by fuel deposits; these localized phenomena were correlated to observed changes in engine performance and pollutant species. With gasoline fueling, minor modifications were observed with respect to combustion parameters... [more]
Probabilistic Power Flow Method Considering Continuous and Discrete Variables
Xuexia Zhang, Zhiqi Guo, Weirong Chen
December 10, 2019 (v1)
Keywords: cumulant method (CM), deterministic power flow (DPF) calculation, discrete variable, probabilistic power flow (PPF)
This paper proposes a probabilistic power flow (PPF) method considering continuous and discrete variables (continuous and discrete power flow, CDPF) for power systems. The proposed method—based on the cumulant method (CM) and multiple deterministic power flow (MDPF) calculations—can deal with continuous variables such as wind power generation (WPG) and loads, and discrete variables such as fuel cell generation (FCG). In this paper, continuous variables follow a normal distribution (loads) or a non-normal distribution (WPG), and discrete variables follow a binomial distribution (FCG). Through testing on IEEE 14-bus and IEEE 118-bus power systems, the proposed method (CDPF) has better accuracy compared with the CM, and higher efficiency compared with the Monte Carlo simulation method (MCSM).
Experimental Investigation of the Transpired Solar Air Collectors and Metal Corrugated Packing Solar Air Collectors
Wandong Zheng, Huan Zhang, Shijun You, Yindan Fu
December 10, 2019 (v1)
Keywords: cold and severe cold regions, experimental study, solar air collector, thermal performance
The thermal performance of three novel solar air collectors with perforating corrugated plate, slit-perforated plate, and corrugated packing were experimentally studied in this paper. Experiments were conducted in Tianjin to study the thermal and dynamic performance of the collectors in cold and severe cold regions. A chamber with a PID (Proportion Integration Differentiation) temperature controller was designed to control the inlet air temperature of the three collectors. Effects of radiation intensity, inlet air temperature, and flow rate on the thermal efficiency and outlet air temperature were experimentally studied. The results indicated that the thermal efficiency of the three collectors in severe cold regions could be much higher than 50% and the collector with perforating corrugated plate had the highest thermal efficiency. The inlet air flow rate had significant effects on the thermal comfort of buildings in cold and severe cold regions and it should be lower than 45 m³/h. The... [more]
Effects of a Dynamic Injection Flow Rate on Slug Generation in a Cross-Junction Square Microchannel
Jin-yuan Qian, Min-rui Chen, Zan Wu, Zhi-jiang Jin, Bengt Sunden
December 10, 2019 (v1)
Keywords: Computational Fluid Dynamics, dynamic injection flow rate, liquid-liquid slug flow, microchannel, slug generation
The injection flow rates of two liquid phases play a decisive role in the slug generation of the liquid-liquid slug flow. However, most injection flow rates so far have been constant. In order to investigate the effects of dynamic injection flow rates on the slug generation, including the slug size, separation distance and slug generation cycle time, a transient numerical model of a cross-junction square microchannel is established. The Volume of Fluid method is adopted to simulate the interface between two phases, i.e., butanol and water. The model is validated by experiments at a constant injection flow rate. Three different types of dynamic injection flow rates are applied for butanol, which are triangle, rectangular and sine wave flow rates. The dynamic injection flow rate cycles, which are related to the constant slug generation cycle time t0, are investigated. Results show that when the cycle of the disperse phase flow rate is larger than t0, the slug generation changes periodica... [more]
Implementation of Production Process Standardization—A Case Study of a Publishing Company from the SMEs Sector
Arturo Realyvásquez-Vargas, Francisco Javier Flor-Moltalvo, Julio Blanco-Fernández, Joanna Denisse Sandoval-Quintanilla, Emilio Jiménez-Macías, Jorge Luis García-Alcaraz
December 3, 2019 (v1)
Keywords: inefficient movements, line balancing, optimization of productivity, work standardization, workstations redesign
This paper reports a case study using a standardization process for increasing efficiency and a better optimization of resources in a printing company with 150 operators having manual and mechanical tasks in the box assembly department along with four production lines. The current capacity is 350 boxes per day, while the demand is 650 units, where the company is expected to pay large sums for overtime. Using work standardization, studying worker movements, timing, and workstations redesign, the main goal was to increase the efficiency and productivity indexes. After applying those tools, the inefficient movements in operators decreased from 230 to 78, eliminating 66% of the unnecessary movements, as well as the standard time in a workstation decreased from 244 to 199 s (18.44%) per each assembled box, and the production rate increased by 63.2%, that is, 229 units per assembly line a day, where overtime was reduced to zero.
Using PSO Algorithm to Compensate Power Loss Due to the Aeroelastic Effect of the Wind Turbine Blade
Ying Zhao, Caicai Liao, Zhiwen Qin, Ke Yang
November 24, 2019 (v1)
Keywords: aeroelastic effect, optimization model, power loss, pretwist angle, pretwisting method
Power loss due to the aeroelastic effect of the blade is becoming an important problem of large-scale blade design. Prior work has already employed the pretwisting method to deal with this problem and obtained some good results at reference wind speed. The aim of this study was to compensate for the power loss for all of the wind speeds by using the pretwisting method. Therefore, we developed an aeroelastic coupling optimization model, which takes the pretwist angles along the blade as free variables, the maximum AEP (annual energy production) as the optimal object, and the smooth of the twist distribution as one of the constraint conditions. In this optimization model, a PSO (particle swarm optimization) algorithm is used and combined with the BEM-3DFEM (blade element momentum—three-dimensional finite element method) model. Then, the optimization model was compared with an iteration method, which was recently developed by another study and can well compensate the power loss at referen... [more]
Numerical Simulation and Performance Prediction of Centrifugal Pump’s Full Flow Field Based on OpenFOAM
Si Huang, Yifeng Wei, Chenguang Guo, Wenming Kang
November 24, 2019 (v1)
Keywords: centrifugal pump, numerical simulation, OpenFOAM, performance prediction
The open-source software OpenFOAM 5.0 was used as a platform to perform steady-state and transient numerical simulation for full flow field of a pipeline centrifugal pump (specific speed ns = 65) in a wide operating capacity range of 0.3Qd~1.4Qd. The standard k-ε and k-ω SST (Shear-Stress Transport) turbulence models were selected in the flow governing equations. The simpleFoam and pimpleDyMFoam solvers were used for the steady-state and transient calculations, respectively. ParaView, the postprocessor in OpenFOAM, was used to display the calculated flow velocity, pressure and streamline distributions, and to analyze the relationship between the vortex and the hydraulic loss in the pump. The external performance parameters of the pump such as head, input power and efficiency were also calculated based on the simulated flow fields. The predicted pump performances by OpenFOAM and Ansys-Fluent are compared with the test results under the same calculation model, grids and boundary conditio... [more]
Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing
Martin Kornecki, Axel Schmidt, Lara Lohmann, Maximilian Huter, Fabian Mestmäcker, Leon Klepzig, Mourad Mouellef, Steffen Zobel-Roos, Jochen Strube
September 30, 2019 (v1)
Keywords: antibodies, continuous bioprocessing (CBP), model validation, process analytical technology (PAT), quality-by-design (QbD)
An experimental feasibility study on continuous bioprocessing in pilot-scale of 1 L/day cell supernatant, that is, about 150 g/year product (monoclonal antibody) based on CHO (Chinese hamster ovary) cells for model validation is performed for about six weeks including preparation, start-up, batch, and continuous steady-state operation for at least two weeks stable operation as well as final analysis of purity and yield. A mean product concentration of around 0.4 g/L at cell densities of 25 × 106 cells/mL was achieved. After perfusion cultivation with alternating tangential flow filtration (ATF), an aqueous two-phase extraction (ATPE) followed by ultra-/diafiltration (UF/DF) towards a final integrated counter-current chromatography (iCCC) purification with an ion exchange (IEX) and a hydrophobic interaction (HIC) column prior to lyophilization were successfully operated. In accordance to prior studies, continuous operation is stable and feasible. Efforts of broadly-qualified operation p... [more]
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