Evaporative cooling can be integrated into fresh-air-handling units, to reduce cooling demand. This study considers a hybrid fresh-air-handling unit which incorporates a vapor-compression cooling cycle and indirect evaporative cooling to condition an ambient primary airstream to a desired supply air state. The cooling effects of using various modes (vapor compression only; direct expansion with mist; direct expansion with water shower; and direct expansion with mist and water shower) are compared when the fresh-air-handling unit operates in harsh (hot and humid) climatic conditions experienced in Qatar. Experimental analysis is based on actual ambient conditions measured from August 2018 to July 2019. It is found that the best-performing wet mode of operation saves more than 60% of the energy required by a conventional direct expansion cooling system operating under the same ambient conditions. In hot, dry conditions, the coefficient of performance of the fresh-air-handling unit when using the indirect evaporative mode of operation is double the coefficient of performance when operating with direct expansion mode only.