Algorithms that compute locally optimal continuous designs often rely on a finite design space or on the repeated solution of difficult non-linear programs. Both approaches require extensive evaluations of the Jacobian Df of the underlying model. These evaluations are a heavy computational burden. Based on the Kiefer-Wolfowitz Equivalence Theorem, we present a novel design of experiments algorithm that computes optimal designs in a continuous design space. For this iterative algorithm, we combine an adaptive Bayes-like sampling scheme with Gaussian process regression to approximate the directional derivative of the design criterion. The approximation allows us to adaptively select new design points on which to evaluate the model. The adaptive selection of the algorithm requires significantly less evaluations of Df and reduces the runtime of the computations. We show the viability of the new algorithm on two examples from chemical engineering.

An improved continuous-cycling method is proposed for the autotuning of the proportional−integral−derivative (PID) controller. The proposed method can identify the frequency response of the process at a preset phase angle without a modeling error. Moreover, it provides an exact frequency response even if a static disturbance is present. The proposed method is an improved version of the continuous-cycling method. The gain of the proportional controller in the continuous-cycling method is updated to obtain the continuous-cycling status automatically. To guarantee the preset phase angle of the frequency response, we place a phase shifter in the form of a time delay after the proportional controller. The results of simulation and experimental studies show that the proposed method can provide an exact frequency response even under static disturbance conditions and can be applied to real processes.

In the present research, activated carbon-supported sulfonic acid catalysts were synthesized and tested as pretreatment agents for the conversion of switchgrass into glucose. The catalysts were synthesized by reacting sulfuric acid, methanesulfonic acid, and p-toluenesulfonic acid with activated carbon. The characterization of catalysts suggested an increase in surface acidities, while surface area and pore volumes decreased because of sulfonation. Batch experiments were performed in 125 mL serum bottles to investigate the effects of temperature (30, 60, and 90 °C), reaction time (90 and 120 min) on the yields of glucose. Enzymatic hydrolysis of pretreated switchgrass using Ctec2 yielded up to 57.13% glucose. Durability tests indicated that sulfonic solid-impregnated carbon catalysts were able to maintain activity even after three cycles. From the results obtained, the solid acid catalysts appear to serve as effective pretreatment agents and can potentially reduce the use of convention... [more]

Non-intrusive load monitoring (NILM) is a fast developing technique for appliances operation recognition in power system monitoring. At present, most NILM algorithms rely on the assumption that all fluctuations in the data stream are triggered by identified appliances. Therefore, NILM of identifying unidentified appliances is still an open challenge. To pursue a scalable solution to energy monitoring for contemporary unidentified appliances, we propose a voltage-current (V-I) trajectory enabled deep pairwise-supervised hashing (DPSH) method for NILM. DPSH performs simultaneous feature learning and hash-code learning with deep neural networks, which shows higher identification accuracy than a benchmark method. DPSH can generate different hash codes to distinguish identified appliances. For unidentified appliances, it generates completely new codes that are different from codes of multiple identified appliances to distinguish them. Experiments on public datasets show that our method can... [more]

Vortex Generators (VGs) are applied before the expected region of separation of the boundary layer in order to delay or remove the flow separation. Although their height is usually similar to that of the boundary layer, in some applications, lower VGs are used, Sub-Boundary Layer Vortex Generators (SBVGs), since this reduces the drag coefficient. Numerical simulations of sub-boundary layer vane-type vortex generators on a flat plate in a negligible pressure gradient flow were conducted using the fully resolved mesh model and the cell-set model, with the aim on assessing the accuracy of the cell-set model with Reynolds-Averaged Navier-Stokes (RANS) and Large Eddy Simulation (LES) turbulence modelling techniques. The implementation of the cell-set model has supposed savings of the 40% in terms of computational time. The vortexes generated on the wake behind the VG; vortical structure of the primary vortex; and its path, size, strength, and produced wall shear stress have been studied. Th... [more]

Given apple, an easily adapted culture, and a large number of apple varieties, the production of apple cider is widespread globally. Through the fermentation process, a series of chemical changes take place depending on the apple juice composition, type of microorganism involved and technology applied. Following both fermentations, alcoholic and malo-lactic, and during maturation, the sensory profile of cider changes. This review summarises the current knowledge about the influence of apple variety and microorganisms involved in cider fermentation on the sensory and volatile profiles of cider. Implications of both Saccharomyces, non-Saccharomyces yeast and lactic acid bacteria, respectively, are discussed. Also are presented the emerging technologies applied to cider processing (pulsed electric field, microwave extraction, enzymatic, ultraviolet and ultrasound treatments, high-pressure and pulsed light processing) and the latest trends for a balanced production in terms of sustainabili... [more]

A borehole heat exchanger (BHE) presents the most reliable source of geothermal energy for any object where the heat pump system is to be installed. The main objective of BHE optimization in a specific rock massive and for calculated heat consumption is to design a BHE with proper capacity and sustainable performance. One of the most important inputs for the preparation of such a model is the average outer air temperature on the site during the year. While the properties of the local rock massive are from the heat project lifetime view (tens of years) stable, the local average outer temperature fluctuates according to global climate changes. This article presents a study of the impact of climate changes on the dimensioning process of a BHE and consequently on its performance using data from a real installation at a highly climate-exposed site in the Czech Republic. During the dimensioning of a BHE, this study could help to better quantify the objective risks that result from climate ch... [more]

In recent years, there has been a trend in the global oil industry to improve the proportion of heavy high-sulfur crude oils in the total volume of extracted and processed resources, reserves of which are estimated at over 800 billion metric tons. Therefore, the main line of oil refining is processing of heavy crudes and residua to allow maximum use of the hydrocarbon potential and yield of high-margin products. Hydrogenation processes of heavy raw materials are most attractive in terms of product quality. This article analyzes tar hydrocracking processes that are either in operation or at the stage of full-scale testing. These include Veba Combi-Cracker (VCC), Uniflex, suspended-bed catalyst hydrocracking (ENI), and vacuum residue hydroconversion (TIPS RAS). These technologies use heterogeneous catalysts and are designed to obtain the largest possible amount of liquid products. This article discusses the features of each technology, highlights their advantages and disadvantages, shows... [more]

The startup process occurs frequently for pumped storage units. During this process, the rotating rate that changes rapidly and unsteady flow in runner cause the complex dynamic response of runner, sometimes even resonance. The sharp rise of stress and the large-amplitude dynamic stresses of runner will greatly shorten the fatigue life. Thus, the study of start-up process in turbine mode is critical to the safety operation. This paper introduced a method of coupling one dimensional (1D) pipeline calculation and three-dimensional computational dynamics (3D CFD) simulation to analyze transient unsteady flow in units and to obtain more accurate and reliable dynamic stresses results during start up process. According to the results, stress of the ring near fixed support increased quickly as rotating rate rose and became larger than at fillets of leading edge and band in the later stages of start-up. In addition, it was found that dynamic response can be caused by rotor stator interaction (... [more]

This article aims to develop a proton exchange membrane (PEM) electrolyzer emulator. This emulator is realized through an equivalent electrical scheme. It allows taking into consideration the dynamic operation of PEM electrolyzers, which is generally neglected in the literature. PEM electrolyzer dynamics are reproduced by the use of supercapacitors, due to the high value of the equivalent double-layer capacitance value. Steady-state and dynamics operations are investigated in this work. The design criteria are addressed. The PEM electrolyzer emulator is validated by using a 400-W commercial PEM electrolyzer. This emulator is conceived to test new DC-DC converters to supply the PEM ELs and their control as well, avoiding the risk to damage a real electrolyzer for experiment purposes. The proposed approach is valid both for a single cell and for the whole stack emulation.

Traditional wisdom suggests that the interchangeable design in process system engineering, such as modularity or commonality design, can lower the manufacturing cost and act as a revenue driver. Moreover, the interchangeable design will be efficient in both assembling for new production and disassembling for remanufacturing. As such, interchangeable design confronted remanufacturing processing often involves a balance of revenue from cost drivers and cannibalization effects from remanufacturing. Therefore, this paper studies how the original equipment manufacturers’ (OEMs’) interchangeable design impacts the remanufacturing decisions, as well as the economy and environment. Specifically, we develop two theoretical models, in which an OEM makes a strategic choice relating to design interchangeability when the remanufacturing operations are undertaken by itself (Model O) or outsourced to third-party remanufacturers (Model T). This study finds that, although the optimal level of interchan... [more]

Dissolved oxygen plays a key role in microalgal growth at high density. This effect was so far rarely quantified. Here we propose a new model to represent the combined effect of light, oxygen concentration and temperature (LOT-model) on microalgae growth. The LOT-model introduces oxygen concentration in order to represent the oxidative stress affecting the cultures, adding a toxicity term in the expression of the net growth rate. The model was validated with experimental data for several species such as Chlorella minutissima, Chlorella vulgaris, Dunaliella salina, Isochrysis galbana. It successfully predicted experimental records with an average error lower than 5.5%. The model was also validated using dynamical data where oxygen concentration varies. It highlights a strong impact of oxygen concentration on productivity, depending on temperature. The model quantifies the sensitivity to oxidative stress of different species and shows, for example, that Dunaliella salina is much less aff... [more]

Tripartite motif 21 (TRIM21) plays an important role in hepatocellular carcinoma (HCC). However, the gene polymorphisms of TRIM21 in HCC is not as well known. In this study, two single nucleotide polymorphisms (SNPs) in the TRIM21 gene, rs4144331, and re915956, were selected to investigate correlations between these SNPs and susceptibility to HCC. Two SNPs of the TRIM21 gene from 1196 controls without cancer and 394 HCC patients were analyzed using real-time polymerase chain reaction. These results were further analyzed to expound the associations between these TRIM21 polymorphisms and the risk of HCC as well as the impact of these SNPs on clinicopathological characteristics of HCC. After adjustment for other covariants, we observed that that younger patients (<65 years) with the TRIM21 rs915956 A allele had a probability of HCC (AOR = 3.153, 95% CI: 1.315−7.516, p = 0.010). Moreover, patients with a smoking habit who carried the T allele of rs4144331 had more probability of HCC (AO... [more]

Biorefinery, which utilizes carbon-neutral biomass as a resource, is attracting attention as a significant alternative in a modern society confronted with climate change. In this study, spent coffee grounds (SCGs) were used as the feedstock for lactic acid fermentation. In order to improve sugar conversion, alkali pretreatment was optimized by a statistical method, namely response surface methodology (RSM). The optimum conditions for the alkali pretreatment of SCGs were determined as follows: 75 °C, 3% potassium hydroxide (KOH) and a time of 2.8 h. The optimum conditions for enzymatic hydrolysis of pretreated SCGs were determined as follows: enzyme complex loading of 30-unit cellulase, 15-unit cellobiase and 50-unit mannanase per g biomass and a reaction time of 96 h. SCG hydrolysates were used as the carbon source for Lactobacillus cultivation, and the conversions of lactic acid by L. brevis ATCC 8287 and L. parabuchneri ATCC 49374 were 40.1% and 55.8%, respectively. Finally, the maxi... [more]

A hydrothermal pre-treatment has been developed to improve sewage sludge quality or to produce low nitrogen biocrude via hydrothermal liquefaction (HTL) in a subsequent step. The mild hydrothermal pre-treatment (150 °C) step was performed with deionized water, sulfuric acid (0.5 M), or citric acid (0.5 M) to solubilize nitrogen containing compounds in the aqueous supernatant. Downstream, the residual solid material was liquefied with the addition of sodium carbonate via hydrothermal liquefaction (350 °C). The pre-treatment with citric acid transferred up to 66.7 wt. % of nitrogen into the aqueous supernatant, while 62.0 wt. % of carbon was recovered in the solid. Due to the pre-treatment lipids retained in the sewage sludge solid, which increased the favored biocrude yield up to 42.9 wt. % and the quality evaluating value H/Ceff ratio significantly to 1.48. Multi-method characterization of the resulted biocrude samples showed a lower concentration of N-heterocycles, while long-chain al... [more]

The objective of the study was to investigate a more effective use of commercially available biomass pellets (wheat straw, wood, peat) using microwave pretreatment to improve heat production. Pellets were pretreated using the originally designed microwave torrefaction device. The effects of microwave (mw) pretreatment were quantified, providing measurements of the weight loss and elemental composition of pellets and estimating the effect of mw pretreatment on their porosity, surface area and calorific values at pretreatment temperatures of T = 448−553 K. Obtained results show that the highest structural variations and elemental composition during mw pretreatment were obtained for wheat straw pellets, with an increase in reactivity, a decreasing in the duration of the thermal decomposition by about 40% and an increase in the yield of combustible volatiles. Increased reactivity of pretreated pellets enhanced the ignition and burnout of volatiles, decreasing the duration of the burnout of... [more]

In this paper, an arc was drawn over ten years of research activities from three chairs of the Montanuniversitaet Leoben, as well as industrial partners. The superior objective of this research effort was to develop a wet-mechanical process for the recovery of polyolefin concentrates (90 wt% polyolefins) from mixed waste fraction for use in chemical recycling and to advance this new technology to commercial maturity. As a bridge technology, it would close the gap between state-of-the-art dry processing of mixed plastic waste materials and chemical plastic recycling via thermo-chemical conversion. The methods used were mainly tested in a lab-scale plant with a throughput capacity of 50 to 200 kg/h depending on the bulk density of the used feedstock. Further studies for the treatment and usage of the main products and by-products, as well as chemical analyses of them, were completed during the investigation. Within these series of tests, polyolefin concentrates, which satisfied the requi... [more]

Supercritical carbon dioxide + ethanol (SC-CO2+EtOH) extraction, was employed as a deflavoring method to improve the sensory properties of pea flours. Furthermore, the impacts of particle size along with extraction on volatile profile and sensory attributes of pea flours were investigated using multiple approaches. These included headspace solid-phase microextraction-gas chromatography (HS-SPME-GC), GC-olfactometry (GC-O), and quantitative descriptive analysis (QDA) using a trained sensory panel. Total volatile contents of non-deflavored and deflavored whole pea flour and its fractions were in the range of 7.1 ± 0.3 to 18.1 ± 1.0 µg/g and 0.4 ± 0.1 to 2.7 ± 0.4 µg/g, respectively. The GC-O system showed that the total volatile intensity was in the range of 14.5 to 22.0 and 0 to 3.5, for non-deflavored and deflavored pea flours, respectively. Volatile analyses indicated that 1-hexanol, 1-octanol, 1-nonanol, nonanal, and 2-alkyl methoxypyrazines were major off-aroma compounds. Most off-a... [more]

The development of a bio-based economy has its foundations in the development of efficient processes to optimize biomass potential. In this context there are a multitude of molecules that can be either synthetized or recovered from biomass, among those the so-called 12 building-blocks reported by the US Department of Energy. Even if their identification and importance is clearly defined, research efforts concerning the purification or separation of these platform molecules are limited. To fill this gap, different configurations for the purification of levulinic acid recovered from lignocellulosic biomass are examined and compared in this work. In particular, hybrid configurations obtained by the combination of liquid-liquid extraction and distillation have been considered. It was demonstrated how a deep understanding of the subspace including all extraction-assisted simple column distillation configurations represents a fundamental step in the synthesis of different process alternative... [more]

The integration of real time release testing into an advanced process control (APC) concept in combination with digital twins accelerates the process towards autonomous operation. In order to implement this, on the one hand, measurement technology is required that is capable of measuring relevant process data online, and on the other hand, a suitable model must be available to calculate new process parameters from this data, which are then used for process control. Therefore, the feasibility of online measurement techniques including Raman-spectroscopy, attenuated total reflection Fourier transformed infrared spectroscopy (ATR-FTIR), diode array detector (DAD) and fluorescence is demonstrated within the framework of the process analytical technology (PAT) initiative. The best result is achieved by Raman, which reliably detected mAb concentration (R2 of 0.93) and purity (R2 of 0.85) in real time, followed by DAD. Furthermore, the combination of DAD and Raman has been investigated, which... [more]

Although many benefits drawn from beer consumption are claimed, the epidemiological records are contradictory with respect to cancer prevention. The purpose of this study was to investigate the possible health-related activities involving genome safety and the ageing processes of two types of lyophilised ale beers (blond and stout), as well as two of their bioactive compounds (tyrosol and iso-alpha humulone). A multipurpose trial set of in vivo toxicity, antitoxicity, mutagenicity, antimutagenicity, lifespan and healthspan assays using Drosophila melanogaster were used. In parallel, several in vitro assays were designed using the cancer cell line HL-60 in order to establish the possible chemopreventive activity of the selected substances, where epigenetic modulation of DNA methylation changes, clastogenic activity and tumour cell inhibition growth were evaluated. The safety of the four substances was confirmed: lyophilised blond ale beer (LBAB), lyophilised stout ale beer (LSAB), tyros... [more]

Proportional−integral−derivative (PID) control remains the primary choice for industrial process control problems. However, owing to the increased complexity and precision requirement of current industrial processes, a conventional PID controller may provide only unsatisfactory performance, or the determination of PID gains may become quite difficult. To address these issues, studies have suggested the use of reinforcement learning in combination with PID control laws. The present study aims to extend this idea to the control of a multiple-input multiple-output (MIMO) process that suffers from both physical coupling between inputs and a long input/output lag. We specifically target a thin film production process as an example of such a MIMO process and propose a self-tuning two-degree-of-freedom PI controller for the film thickness control problem. Theoretically, the self-tuning functionality of the proposed control system is based on the actor-critic reinforcement learning algorithm.... [more]

Uncertainty and variability are inherent to pile design and consequently, there have been considerable researches in quantifying the reliability or probability of failure of structures. This paper aims at examining and comparing the applicability and adaptability of Minimax Probability Machine Regression (MPMR), Emotional Neural Network (ENN), Group Method of Data Handling (GMDH), and Adaptive Neuro-Fuzzy Inference System (ANFIS) in the reliability analysis of pile embedded in cohesionless soil and proposes an AI-based prediction method for bearing capacity of pile foundation. To ascertain the homogeneity and distribution of the datasets, Mann−Whitney U (M−W) and Anderson−Darling (AD) tests are carried out, respectively. The performance of the developed soft computing models is ascertained using various statistical parameters. A comparative study is implemented among reliability indices of the proposed models by employing First Order Second Moment Method (FOSM). The results of FOSM sho... [more]

In this study, we examined the effect of ethanolic extract of Salicornia herbacea (ESH), isorhamnetin 3-O-glucoside (I3G), quercetin 3-O-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC50 value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activa... [more]

Cubing machines in food processing have evolved over the years, which have made products like Star®, Knorr®, and Chicken® bouillon cubes become commercially available today, even in many parts of Africa. On the other hand, the fermented mesquite seed “okpeye” food condiment, traditionally produced by well-trained artisans and widely utilised in Nigeria, requires further product development in order to compete with bouillon cubes. Quality comparisons between the cubed “okpeye” condiment and commercially available bouillon cube products have not yet been reported. Therefore, cubing fabrication/costing and machine performance on African fermented “okpeye” condiment quality attributes, compared with commercial bouillon types, were done. The processing of mesquite seeds into the “okpeye” condiment resembled those of artisans. Bouillon cube products involved the Star®, Knorr®, and Chicken® types. Quality attributes involved proximate, micronutrient, phytochemical, and microbial aspects. Resu... [more]