LAPSE:2023.24758
Published Article
LAPSE:2023.24758
Analysis of TRIM21 Genetic Variants on the Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma
March 28, 2023
Tripartite motif 21 (TRIM21) plays an important role in hepatocellular carcinoma (HCC). However, the gene polymorphisms of TRIM21 in HCC is not as well known. In this study, two single nucleotide polymorphisms (SNPs) in the TRIM21 gene, rs4144331, and re915956, were selected to investigate correlations between these SNPs and susceptibility to HCC. Two SNPs of the TRIM21 gene from 1196 controls without cancer and 394 HCC patients were analyzed using real-time polymerase chain reaction. These results were further analyzed to expound the associations between these TRIM21 polymorphisms and the risk of HCC as well as the impact of these SNPs on clinicopathological characteristics of HCC. After adjustment for other covariants, we observed that that younger patients (<65 years) with the TRIM21 rs915956 A allele had a probability of HCC (AOR = 3.153, 95% CI: 1.315−7.516, p = 0.010). Moreover, patients with a smoking habit who carried the T allele of rs4144331 had more probability of HCC (AOR = 2.940, 95% CI: 1.331−6.491, p = 0.008). In addition, we observed that the polymorphic T allele of rs4144331 led to distant metastasis. Thus, our findings suggest that genetic variations in TRIM21 may correlate to HCC and evaluate distant metastasis in patients with HCC.
Record ID
Keywords
hepatocellular carcinoma (HCC), single nucleotide polymorphism (SNP), tripartite motif 21 (TRIM21)
Subject
Suggested Citation
Lee HL, Chien YC, Chiang WL, Wang HL, Hsueh KC, Chen CH, Chen SC, Wu TK, Pan YR, Bai LY, Yang SF, Yu YL. Analysis of TRIM21 Genetic Variants on the Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma. (2023). LAPSE:2023.24758
Author Affiliations
Lee HL: School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Department of Surgery, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
Chien YC: Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan; Ph.D. Program for Translational Medicine, China Medical University, Taichung 40402, Taiwan; Institute of New Drug Development, China Medical University, Taichung
Chiang WL: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan
Wang HL: Department of Beauty Science, National Taichung University of Science and Technology, Taichung 40404, Taiwan
Hsueh KC: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Division of General Surgery, Department of Surgery, Tungs’ Taichung MetroHarbor Hospital, Taichung 43302, Taiwan
Chen CH: Department of Neurosurgery, China Medical University Hospital, Taichung 40402, Taiwan [ORCID]
Chen SC: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan
Wu TK: Division of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung 43503, Taiwan
Pan YR: Division of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung 43503, Taiwan
Bai LY: Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan
Yang SF: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan [ORCID]
Yu YL: Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan; Ph.D. Program for Translational Medicine, China Medical University, Taichung 40402, Taiwan; Institute of New Drug Development, China Medical University, Taichung [ORCID]
Chien YC: Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan; Ph.D. Program for Translational Medicine, China Medical University, Taichung 40402, Taiwan; Institute of New Drug Development, China Medical University, Taichung
Chiang WL: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan
Wang HL: Department of Beauty Science, National Taichung University of Science and Technology, Taichung 40404, Taiwan
Hsueh KC: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Division of General Surgery, Department of Surgery, Tungs’ Taichung MetroHarbor Hospital, Taichung 43302, Taiwan
Chen CH: Department of Neurosurgery, China Medical University Hospital, Taichung 40402, Taiwan [ORCID]
Chen SC: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan
Wu TK: Division of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung 43503, Taiwan
Pan YR: Division of Renal Medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung 43503, Taiwan
Bai LY: Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan
Yang SF: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan [ORCID]
Yu YL: Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan; Ph.D. Program for Translational Medicine, China Medical University, Taichung 40402, Taiwan; Institute of New Drug Development, China Medical University, Taichung [ORCID]
Journal Name
Processes
Volume
9
Issue
3
First Page
495
Year
2021
Publication Date
2021-03-09
Published Version
ISSN
2227-9717
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PII: pr9030495, Publication Type: Journal Article
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LAPSE:2023.24758
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doi:10.3390/pr9030495
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Mar 28, 2023
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Mar 28, 2023
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