In order to study the effect of freezing and thawing of liquid nitrogen on the mechanical and seepage characteristics of coal rock with different water content values, conventional triaxial loading tests on freeze−thawed coal samples with different water content values were carried out using non-contact digital image processing technology. The research results showed that with the same water content, the peak strength of a liquid nitrogen freeze−thawed coal sample was smaller than that of a non-freeze−thawed coal sample, and the Poisson’s ratio was larger than that of the non-freeze−thawed coal sample; compared with the non-freeze−thawed coal sample, the strain fluctuation and concentration in the stages of compression density, elasticity, yield, and damage were weakened after freeze−thawing by liquid nitrogen, but the local stress concentration was more obvious; the non-freeze−thawed coal sample mainly showed single shear damage, and the damage fissures were inclined fissures with sma... [more]

In the published experimental results, it has been observed that when high-speed steam spurt into the subcooled waterflow, the total pressure along the axial direction at trailing edge of the steam plume shows a pressure-lift. To reveal the mechanism behind this phenomenon, this study utilizes a particle model to investigate the pressure profile of steam jet condensation in subcooled water flow in a narrow pipe. A numerical model based on the Eulerian−Eulerian multiphase model has been developed to accurately simulate the characteristics of pressure profile along the axial direction. The model’s validity is established by comparing the steam plume shape and temperature profiles with the experimental data. By analyzing the total pressure profile of the axis and the contours of gas volume fraction, it is found that there exists a pressure-lift phenomenon at trailing edge of the steam plume. The dynamic pressure of the water also shows a pressure-lift at this position, so it can be inferr... [more]

Algae-based wastewater treatment is a promising technology with various applications for excess biomass such as biofertilizer production or valuable elements extraction. The benefits of the technology have been discussed for larger wastewater treatment plants (WWTPs), but the use of microalgae in decentralized wastewater treatment has been barely reported. The current study screens the possible resource recovery potential of onsite technology, which adds algae-based post-treatment to the conventional biological treatment of domestic wastewater. The effluent from the onsite sequencing batch reactor (SBR) of a household was further processed in laboratory conditions using an SBR technology with two local monocultures of algae—Klebsormidium nitens (Kützing) Lokhorst and Tetradesmus obliquus (Turpin) M. J. Wynne. The decant and the generated algal biomass were analyzed in terms of their element content. The post-treated effluent has a slightly better quality for irrigation purposes than th... [more]

This Special Issue entitled “Application of Proteomics and Enzyme Technologies in Foods” explores the latest progress and perspectives on the development and application of enzyme technologies, proteomics, and bioprocessing in the context of food science [...]

Menaquinone-7 (MK-7) provides significant health gains due to its excellent pharmacokinetic properties. However, MK-7 occurs at low concentrations in mainstream foods, heightening the demand for nutritional supplements. MK-7 exists as geometric isomers, and only all-trans MK-7 is bioactive. Exposure to certain environments impacts the isomer profile. Knowledge of these factors and their influence on the isomer composition is important, as the efficacy of fermented MK-7 end products is solely determined by the all-trans isomer. This investigation aimed to evaluate the short- and long-term effect of atmospheric oxygen, common temperatures, and light on the isomer profile. From the short-term study, it was ascertained that MK-7 is moderately heat-stable but extremely light-sensitive. The stability of all-trans MK-7 was then examined during 8 weeks of storage at a low temperature with minimal oxygen exposure in the absence of light. Negligible change in the all-trans MK-7 concentration occ... [more]

Turbine energy recovery is a process energy saving technology, and understanding turbine efficiency has important operational and economic benefits for the operator of a power plant. There are three main areas of research into turbine energy efficiency: the structural performance of the turbine itself, the configuration of the recovery device and the regulation of operating conditions. This paper summarizes recent research advances in hydraulic turbine energy efficiency improvement, focusing on the design factors that can affect the overall efficiency of a hydraulic turbine. To quantify the impact of these factors, this paper investigates the effects of surface roughness, flow rate, head and impeller speed on overall efficiency. Methods for optimizing improvements based on these design factors are reviewed, and two methods, the Box−Behnken Design method and the NSGA-II genetic algorithm, are described with practical examples to provide ideas for future research.

In today’s rapidly evolving manufacturing landscape with the advent of intelligent technologies, ensuring smooth equipment operation and fostering stable business growth rely heavily on accurate early fault detection and timely maintenance. Machine learning techniques have proven to be effective in detecting faults in modern production processes. Among various machine learning algorithms, the Backpropagation (BP) neural network is a commonly used model for fault detection. However, due to the intricacies of the BP neural network training process and the challenges posed by local minima, it has certain limitations in practical applications, which hinder its ability to meet efficiency and accuracy requirements in real-world scenarios. This paper aims to optimize BP networks and develop more effective fault warning methods. The primary contribution of this research is the proposal of a novel hybrid algorithm that combines a random wandering strategy within the main loop of an equilibrium... [more]

Quinine hydrochloride (QHCl) has remained a very relevant antimalarial drug 400 years after its effectiveness was discovered. Unlike other antimalarials, the development of resistance to quinine has been slow. Hence, this drug is to date still used for the treatment of severe and cerebral malaria, for malaria treatment in all trimesters of pregnancy, and in combination with doxycycline against multidrug-resistant malaria parasites. The decline in its administration over the years is mainly associated with poor tolerability due to its gastrointestinal (GIT) side effects such as cinchonism, complex dosing regimen and bitter taste, all of which result in poor compliance. Hence, our research was aimed at redesigning quinine using nanotechnology and investigating an alternative route for its administration for the treatment of malaria. QHCl nanosuspension (QHCl-NS) for intranasal administration was prepared using lipid matrices made up of solidified reverse micellar solutions (SRMS) compris... [more]

The utilization of natural gas hydrates as an alternative energy source has garnered significant attention due to their proven potential. Despite the successful offshore natural gas hydrate production tests, commercial exploitation has not been achieved. This study aims to enhance the understanding of gas production behavior through simulations from a single vertical well in the Nankai Trough and assess the effectiveness of the step-wise depressurization method for gas production using TOUGH + HYDRATE. The simulation results showed that the effective permeability for the water phase decreased as the hydrates were decomposed, and the invasion of the pore water from the underburden eliminated this effect. Compared with the direct depressurization method, the step-wise depressurization method significantly increased the cumulative gas production by more than 10% and mitigated the rapid generation of gas and water production during the moment of depressurization. The results also indicated... [more]

This study uses high-speed imaging to investigate the dynamic collision behavior of a single hydrous ethanol droplet in different water/ethanol ratios on a heated horizontal glass surface. The initial droplet diameter varied from 3.3 to 4.1 mm, and the impact velocity was 0.57 m/s. The study covers a range of surface temperatures (373 K to 553 K) and ethanol mass fractions (0% to 100%) to reveal four regimes of droplet-impinging behaviors, including quiescent surface evaporation, puffing or partial boiling, explosive nuclear boiling, and the Leidenfrost effect. The addition of volatile ethanol to less volatile water shifts the droplet collision behavior toward explosive boiling and the Leidenfrost phenomenon. As the ethanol mass fraction increased from 0% to 100%, the superheat limit temperature decreased by approximately 80 K, while the Leidenfrost temperature decreased by at least 100 K. The dimensionless droplet diameter in the regime of droplet spreading with quiescent surface evap... [more]

Natural products have always played a vital role in the search for novel drugs, and their exploration continues to captivate researchers in the field of drug discovery and development [...]

Personalized precision medicine is a new direction for medical development, and advanced manufacturing technology can provide effective support for the development of personalized precision medicine. Based on the layered accumulation manufacturing principle, 3D printing technology has unique advantages in personalized rapid manufacturing, and can form complex geometric shape parts at low cost and high efficiency. This article introduces the application progress of 3D printing technology in medical models, surgical navigation templates, invisible aligners, and human implants, analyzes their advantages and limitations, and provides an outlook for the development trend of 3D printing technology in precision medicine.

In order to study the effect of inorganic salt additives on the surface tension of a sodium dodecylbenzene sulfonate (SDBS) solution, the surface tension of the mixed system of six common inorganic salt additives, NaCl, CaCl2, AlCl3, Na2SO4, Na2CO3, and NaHCO3, and SDBS was measured, and the effects of the inorganic salt types, surfactant concentrations and inorganic salt concentrations on the surface tension of the SDBS solution were studied. On this basis, three inorganic salts, NaCl, CaCl2 and Na2SO4, were selected, and their effects on the critical micelle concentration (CMC) of the SDBS solution were studied. The experimental results showed that different inorganic salts had different effects on the surface tension of the SDBS solution. The order of effect of the six inorganic salts on the surface tension of the SDBS solution was CaCl2 > NaCl > Na2SO4 > NaHCO3 > Na2CO3 > AlCl3; when the mass fraction of the SDBS solution is high, the influence of the inorganic salts on the surface... [more]

For further resource utilization of solid waste steel slag and the reduction in biodiesel production costs, this study used steel slag as a carrier to synthesize a CaO-CeO2/slag solid base catalyst for the effective transesterification of palm oil into fatty acid methyl esters (FAMEs). The synthesis involved a two-step impregnation of steel slag with nitrate of calcium and cerium and thermal activation at 800 °C for 180 min. Then, the catalysts’ textural, chemical, and CO2 temperature-programmed desorption properties were characterized. The catalytic activity depended highly on the ratio of Ca-Ce to steel slag mass; the CaO-CeO2/slag-0.8 catalyst showed outstanding performance. Characterization showed that the surface area and total basicity of the Ca-Ce/slag-0.8 catalyst were 3.66 m2/g and 1.289 mmol/g, respectively. The reactivity results showed that FAMEs obtained using 7 wt.% catalyst, 9:1 of methanol-to-palm-oil molar ratio, 180 min reaction duration, and 70 °C reaction temperatur... [more]

Calcium sulfate whiskers (CSWs) were synthesized using purified flue-gas desulfurization (FGD) gypsum as raw materials using a hydrothermal method, where the filtrate was recycled back to the reaction slurry. The study investigated the impact of pH and Cu2+ concentration in the reaction solution with or without reagent compensation. The effects of cycle number on the crystal morphology, phase structure, and productivity of the hydrothermal products were also examined. The findings indicate that the crystal morphology and quality of the CSWs deteriorated as the cycle number increased due to a rise in pH and a decrease in Cu2+ concentrations in the reaction solution without reagent compensation. However, adding a specific amount of H2SO4 and CuCl2 to the slurry with filtrate recycle maintained the long fibrous shape of the hydrothermal products for up to seven cycles while also increasing their productivity from 73.7% to 86%. Regardless of reagent compensation, the cycle number of filtra... [more]

Cavitation and cavitation erosion are complex hydrodynamic behaviors that significantly influence the stability and reliability of pumping units in aerospace and navigation power systems, hydraulic engineering, and other fields. Studies on cavitation have primarily and heavily focused on the collapse of multiple cavitation bubbles; understanding the movement of multiple cavitation bubbles is important for cavitation research. In this study, the collapse process of near-wall double-cavitation bubbles was numerically simulated and experimentally verified, and the evolution of the near-wall double-cavitation bubble collapse was investigated. Two different distances were altered in the study. The distance between the double-cavitation bubble and the distance between the cavitation bubbles and the wall, the effects of dimensionless parameters, such as the near-wall coefficient and the cavitation bubble spacing coefficient, the collapse time, jet angle, and impact load on the wall can be det... [more]

This study compares ripple port, stacked switched capacitor, and capacitive energy storage architectures for active power decoupling, comparing the number of components, performance, energy density, DC-link capacitor reduction, efficiency, and frequency operation to highlight their main benefits and drawbacks for single-phase grid-connected applications. The overview reveals equivalent effective energy density without electrolytic capacitors, as well as enhanced simplicity, performance, and durability, thereby providing stacked switched capacitors as an attractive power-decoupling alternative for multi-stage connected applications, based on the principle that its individual buffer capacitors absorb and deliver energy without tightly constraining their individual terminal voltages, while maintaining a narrow range voltage at the buffer DC port.

This article studies the calculation method for the tooth root bending stress of a high-tooth gear pair with a high contact ratio. The boundary point of the double-tooth meshing zone of the high-tooth gear pair is used as the loading point for the load, and the calculation formula for the bending stress at the dangerous section of the tooth root is obtained. By using ANSYS finite element simulation, the effect of the addendum coefficient, pressure angle, and other gear parameters on the bending stress of the tooth root is studied. The analysis shows that increasing the pressure angle will reduce the bending strength of the tooth root. Increasing the coefficient of a tooth’s top height will lead to an increase in the bending strength of the tooth root. Comparing the finite element analysis (FEA) results with the theoretical calculation results, the analysis shows that under low loads, the maximum error of the theoretical calculation values of the driving toothed gear and driven gear sha... [more]

To solve the problem of considerable deformation of the tailgate in a fully mechanized caving face, the position of the main roof fracture line is first obtained by theoretical calculation, combined with the results of a similar simulation test and numerical simulation analysis. The width of the section coal pillar in the tailgate is determined to be 11.5 m. Based on the distribution characteristics of deviatoric stress and the plastic zone of surrounding rock, combined with the location characteristics and geological conditions, a new zoning control design approach is proposed, a “two pillars, three zones, and three parts” arrangement for the surrounding rock of the tailgate. The targeted two-entry support design is carried out following common engineering practices. Mine pressure monitoring data were used to verify the results of the new two-entry design. The comparison shows that the supporting technology can effectively control the considerable deformation of the surrounding rock,... [more]

In order to solve the problems of domestic and foreign vegetable precision metering devices that easily damage seeds and have low seeding efficiency and poor qualification rate, this paper designs a one-machine for two-row pneumatic combination seeder, which is mainly composed of a pneumatic seeding mechanism and a honeycomb seeding mechanism. The mechanism and other components and theoretical analysis of the working process of the combined seed metering device clarifies the minimum negative pressure for adsorbing a seed during the suction stage, along with the negative pressure required for the seed-carrying stage. It also establishes the seeding speed and movement during planting with the trajectory parameter equation and uses ADAMS software to conduct virtual experiments on the influence of the number of holes, diameters, and heights of different types of honeycomb seeding disks on the success rate of seeding. Based on research on previous pneumatic seeding mechanisms, single factor... [more]

Focusing on the problem of drilling fluid loss circulation due to fractured granite formation in ultra-deepwater drilling in the research area, a novel self-degrading loss-circulation material is developed with polymer resin as the core material, according to the principles of loss-circulation prevention and reservoir and environmental protection. The relevant properties of the novel self-degrading loss-circulation material are evaluated by using tests or experiments. The pressure-bearing properties are evaluated by using a sealing capability test; the self-degrading properties are evaluated by using a self-degrading performance test; the pressure-bearing capability and reservoir protection properties are tested by measuring pressure sealing and gas permeability. The results of the tests and experiments show that the grinding rate of the loss-circulation material is less than 6% under 25 MPa, indicating that the novel loss-circulation material is of high compressive strength. The degra... [more]

The functional significance of cytochrome P450s (CYP) enzymes is their ability to catalyze the biotransformation of xenobiotics and endogenous compounds. P450 enzymes catalyze regio- and stereoselective oxidations of C-C and C-H bonds in the presence of oxygen as a cosubstrate. Initiation of cytochrome P450 catalytic cycle needs an electron donor (NADPH, NADH cofactor) in nature or alternative artificial electron donors such as electrodes, peroxides, photo reduction, and construction of enzymatic “galvanic couple”. In our review paper, we described alternative “handmade” electron sources to support cytochrome P450 catalysis. Physical-chemical methods in relation to biomolecules are possible to convert from laboratory to industry and construct P450-bioreactors for practical application. We analyzed electrochemical reactions using modified electrodes as electron donors. Electrode/P450 systems are the most analyzed in terms of the mechanisms underlying P450-catalyzed reactions. Comparativ... [more]

Calendering is a crucial process in the manufacturing of lithium-ion battery electrodes. However, this process introduces several challenges to the current collector, including uneven stress distribution, stress concentration, and plastic pits, which ultimately impact electrode consistency and safety. It is important to note that the load exerted on the current collector during calendering cannot be determined solely through experimental means. Moreover, due to the extremely thin nature of the current collector, there is a size effect problem. To address these issues, this study establishes a lithium-ion battery cathode model based on real experimental data and conducts a numerical simulation of the calendering process. By obtaining the load applied to the current collector and incorporating it into the crystal plasticity model, we investigate the mechanical behavior of the current collector at the crystal level during calendering. The results demonstrate that the lithium battery catho... [more]

Due to the involvement of hazardous materials and the potential serious accidents that may occur in petrochemical plants, it is of great significance to develop real-time state evaluation methods offering high performance. Data-driven methods have received widespread attention following the development of advanced condition-monitoring systems. However, scarce training samples evaluated under multiple operating conditions are available because of the high stability and reliability requirements of petrochemical plants. In this paper, a real-time state evaluation method based on the technique for order preference by similarity to ideal solution (TOPSIS) is proposed, which circumvents dependence on data samples. First, the positive and negative ideal solutions of TOPSIS are determined using expert experience and the process index control limits of process cards. Then, fixed-value and fixed-interval indices are proposed to address the interval-optimal parameters. Subsequently, a new combine... [more]

This study aimed to evaluate the potential of utilizing aerated concrete (AC) and clay bricks (CB) sourced from construction and demotion waste (CDW) as low-cost adsorbents for the removal of Pb2+ from aqueous solutions. The effects of various parameters, including particle size, solution pH, contact time, adsorbent dosage, and initial Pb2+ concentration, were analyzed through batch experiments. The results indicated that AC performed more efficiently in removing lead ions than CB under all the tested conditions. The highest removal efficiency of Pb2+ with AC was 99.0%, which was achieved at a pH of 5.0, contact time of 1 h, an adsorbent dosage of 5 g/L, and an initial Pb2+ concentration of 100 mg/L. The maximum adsorption capacities of AC and CB were 201.6 mg/g and 56.3 mg/g, respectively. The adsorption isotherm data of the adsorbents were successfully modeled using both the Langmuir and Freundlich models. The removal of lead ions from aqueous solutions by both adsorbents is primaril... [more]