LAPSE:2023.36361
Published Article
LAPSE:2023.36361
Fermentation of Menaquinone-7: The Influence of Environmental Factors and Storage Conditions on the Isomer Profile
July 13, 2023
Menaquinone-7 (MK-7) provides significant health gains due to its excellent pharmacokinetic properties. However, MK-7 occurs at low concentrations in mainstream foods, heightening the demand for nutritional supplements. MK-7 exists as geometric isomers, and only all-trans MK-7 is bioactive. Exposure to certain environments impacts the isomer profile. Knowledge of these factors and their influence on the isomer composition is important, as the efficacy of fermented MK-7 end products is solely determined by the all-trans isomer. This investigation aimed to evaluate the short- and long-term effect of atmospheric oxygen, common temperatures, and light on the isomer profile. From the short-term study, it was ascertained that MK-7 is moderately heat-stable but extremely light-sensitive. The stability of all-trans MK-7 was then examined during 8 weeks of storage at a low temperature with minimal oxygen exposure in the absence of light. Negligible change in the all-trans MK-7 concentration occurred, suggesting it is reasonably stable during prolonged storage in this environment. These findings will aid the development of optimal storage conditions to preserve bioactive MK-7 in fermented nutritional supplements, the large-scale availability and consumption of which will help compensate for the dietary deficit of this essential vitamin and provide consumers with better health outcomes.
Record ID
Keywords
bioactivity, environmental factors, Fermentation, menaquinone-7 isomer profile, storage conditions
Subject
Suggested Citation
Lal N, Seifan M, Berenjian A. Fermentation of Menaquinone-7: The Influence of Environmental Factors and Storage Conditions on the Isomer Profile. (2023). LAPSE:2023.36361
Author Affiliations
Lal N: School of Engineering, The University of Waikato, Hamilton 3240, New Zealand
Seifan M: School of Engineering, The University of Waikato, Hamilton 3240, New Zealand [ORCID]
Berenjian A: School of Engineering, The University of Waikato, Hamilton 3240, New Zealand; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO 80523, USA
Seifan M: School of Engineering, The University of Waikato, Hamilton 3240, New Zealand [ORCID]
Berenjian A: School of Engineering, The University of Waikato, Hamilton 3240, New Zealand; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO 80523, USA
Journal Name
Processes
Volume
11
Issue
6
First Page
1816
Year
2023
Publication Date
2023-06-15
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr11061816, Publication Type: Journal Article
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Published Article
LAPSE:2023.36361
This Record
External Link
doi:10.3390/pr11061816
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Version History
[v1] (Original Submission)
Jul 13, 2023
Verified by curator on
Jul 13, 2023
This Version Number
v1
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URL Here
https://psecommunity.org/LAPSE:2023.36361
Original Submitter
Calvin Tsay
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