In the current investigation, Annona muricata Linn. lyophilized fruit pulp powder was evaluated for its hepatoprotective activity induced by paracetamol or acetaminophen (APAP). Male Sprague Dawley rats were orally pre-treated for 15 days with A. muricata lyophilized fruit pulp powder at low (1 g/kg b.wt) and high doses (2 g/kg b.wt). Silymarin (100 mg/kg) was administered as the standard drug. Hepatotoxicity was induced using APAP, in a single oral administration of 2.5 g/kg body weight dosage on the 15th day. Aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) were elevated in the APAP group but were found to be significantly reduced in the pre-treated groups in a dose-dependent manner. APAP administration brought down the serum total protein and albumin levels significantly. The activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase were reduced in the APAP administration; further, the reduced glutathione pool in the... [more]

The objective of this study was to evaluate the impact of high intensity ultrasound (HIU)-assisted brining on the physicochemical characteristics and consumer preference of smoked pork loin (Longissimus dorsi, LD). LD cuts (5 × 8 × 2.5 cm, length × width × height) were randomly distributed in a 2 × 2 design of two concentration of brine (5 or 10% NaCl) and two methods of brining (static, TC; or HIU for 30 min). After brining, the samples were smoked, cooled, vacuum packed and stored for 7 d at 4 °C. Weight, pH, percentage of NaCl, water-holding capacity (WHC), shear force and colour characteristics were evaluated in post-brining and smoked samples. Sensory analysis was performed to evaluate preference in appearance, taste, and texture characteristics. Weight and NaCl increased in samples post-brining. However, smoked pork samples were not significantly different among treatments. The smoked samples became more yellow and less red. Consumers preferred TC smoked pork based on this appear... [more]

Mold temperature is the key parameter in determining the morphology of molded parts. Uneven temperature distribution could induce significant effects on part performances. In such cases, uneven temperature is induced to analyze the morphology developed in the molded specimens. The technology used for controlling mold temperature during the process is crucial to maintain the short processing time. This paper proposed a strategy for controlling mold temperature during the process, avoiding a significant increase in processing time. A thin electrical heater is designed and adapted below the cavity surface, allowing for the increase of the cavity surface temperature soon after the mold closure, and the fast decrease of the mold temperature soon after the filling. The effect of several heating powers and heating durations on the molecular orientation was analyzed and exploited considering the temperature and flow field realized during the process.

As an unconventional, high-quality, efficient, and clean low-carbon energy, shale gas has become a new bright spot in the exploration and development of global oil and gas resources. However, with the increasing development of shale gas in recent years, the anisotropic load of the shale reservoir during the mining process has caused the casing to be deformed or damaged more and more seriously. In this paper, the mechanical behavior of shale core shear, triaxial and radial compression are studied using rock true compression tests, shear tests and nuclear magnetic resonance (NMR) technology. The process of macroscopic and microscopic changes of shale fractures during the tests were analyzed to predict the effect of the fracture-state changes and stress-state changes of different shale reservoirs on the casing deformation. The results show that after the shale core is damaged, the overall pore structure changes, resulting in the decrease or increase in shale porosity. During the process o... [more]

Today’s global food supply chains are highly dispersed and complex. The adoption and effective utilization of information technology are likely to increase the efficiency of companies. Because of the broad variety of sensors that are currently accessible, the possibilities for Internet of Things (IoT) applications in the olive oil industry are almost limitless. Although previous studies have investigated the impact of the IoT on the performance of industries, this issue has yet to be explored in the olive oil industry. In this study we aimed to develop a new model to investigate the factors influencing supply chain improvement in olive oil companies. The model was used to evaluate the relationship between supply chain improvement and olive oil companies’ performance. Demand planning, manufacturing, transportation, customer service, warehousing, and inventory management were the main factors incorporated into the proposed model. Self-organizing map (SOM) clustering and decision trees we... [more]

The operation of reforming catalysts in a fixed bed reactor undergoes a high level of interaction between the operating parameters and the reaction mechanism. Understanding such an interaction reduces the catalyst deactivation rate. In the present work, three kinds of nanocatalysts (i.e., Pt/HY, Pt-Zn/HY, and Pt-Rh/HY) were synthesized. The catalysts’ performances were evaluated for n-heptane reactions in the fixed bed reactor. The operating conditions applied were the following: 1 bar pressure, WHSV of 4, hydrogen/n-heptane ratio of 4, and the reaction temperatures of 425, 450, 475, 500, and 525 °C. The optimal reaction temperature for all three types of nanocatalysts to produce high-quality isomers and aromatic hydrocarbons was 500 °C. Accordingly, the nanocatalyst Pt-Zn/HY provided the highest catalytic selectivity for the desired hydrocarbons. Moreover, the Pt-Zn/HY-nanocatalyst showed more resistance against catalyst deactivation in comparison with the other two types of nanocatal... [more]

Manufacturing and energy sectors provide vast amounts of maintenance data and information which can be used proactively for performance monitoring and prognostic analysis which lead to improve maintenance planning and scheduling activities. This leads to reduced unplanned shutdowns, maintenance costs and any fatal events that could affect the operations of the overall system. Performance and condition monitoring are among the most used strategies for prognostic and health management (PHM), in which different methods and techniques can be implemented to analyse maintenance and online data. Offshore wind turbines (WTs) are complex systems increasingly needing maintenance. This study proposes a performance monitoring system to monitor the performance of the WT power generation process by exploiting artificial neural networks (ANN) composed of different network designs and training algorithms, using simulated supervisory control and data acquisition (SCADA) data. The performance monitoring... [more]

In this paper, a real-time scheduling problem of a dual-resource flexible job shop with robots is studied. Multiple independent robots and their supervised machine sets form their own work cells. First, a mixed integer programming model is established, which considers the scheduling problems of jobs and machines in the work cells, and of jobs between work cells, based on the process plan flexibility. Second, in order to make real-time scheduling decisions, a framework of multi-task multi-agent reinforcement learning based on centralized training and decentralized execution is proposed. Each agent interacts with the environment and completes three decision-making tasks: job sequencing, machine selection, and process planning. In the process of centralized training, the value network is used to evaluate and optimize the policy network to achieve multi-agent cooperation, and the attention mechanism is introduced into the policy network to realize information sharing among multiple tasks.... [more]

The discrete element method (DEM) often uses the angle of repose to study the microscopic parameters of particles. This paper proposes a multi-objective optimization method combining realistic modeling of particles and image analysis to calibrate gravel parameters, after obtaining the actual static angle of repose (αAoR_S) and dynamic angle of repose (βAoR_D) of the particles by physical tests. The design variables were obtained by Latin hypercube sampling (LHS), and the radial basis function (RBF) surrogate model was used to establish the relationship between the objective function and the design variables. The optimized design of the non-dominated sorting genetic algorithm II (NSGA-II) with the actual angle of repose measurements was used to optimize the design to obtain the best combination of parameters. Finally, the parameter set was validated by a hollow cylinder test, and the relative error between the validation test and the optimized simulation results was only 3.26%. The vali... [more]

Numerical investigations were conducted on the mixing efficiency of resonant acoustic mixing (RAM) technology using a high-viscosity mixture under vertically forced vibrations. The density distribution was analyzed for a mixture of high-melting explosive (HMX) and trinitrotoluene (TNT). The effects of mixing time, amplitude, frequency, fill level, and mixing vessel geometry were evaluated to determine their influence on the blend homogeneity and the efficiency of the mixing process. The results showed that amplitude and frequency both have significant influences on the mixing efficiency of the RAM process. With higher values of amplitude and frequency, the mixing efficiency was very good, and uniform mixing was achieved in a much shorter time. At the same time, it was seen that geometric changes did not affect the mixing process; in contrast, varying the fill level did have a significant effect. This approach could potentially be used for pharmaceutical blending, cosmetics, and explosi... [more]

A standardized method to evaluate the material properties of surimi gels has to be updated because of the lack of accuracy and the repeatability of data obtained from conventional ways. To investigate the relationships between the different texture measurement methods used in surimi gels, 250 batches of different surimi gels were used. The textural properties of surimi gels made with or without whey protein concentrate (SG-WP), potato starch (SG-PS), or dried egg white (SG-EW) were measured under torsion, tensile, and penetration tests. The correlation between the textural properties related to the deformation and hardness of surimi gels without any added ingredients (SG) was linear (R2 > 0.85). However, the R2 values of the shear strain and tensile strain of SG-WP and SG-EW were significantly lower than that of SG. The strain distributions of surimi gels with and without added ingredients were estimated by digital image correlation (DIC) analysis. The results showed that the local str... [more]

Sorption is often carried out in stirred batch reactors without any consideration of how much mixing is sufficient to avoid the effect of diffusion without compromising yield and cost due to overmixing. Therefore, the focus of this work was to study how the maximum sorption capacity, removal efficiency, kinetics and power consumption (P) of the studied process are affected by different mixing speeds, i.e., impeller speed/minimum impeller speed for complete suspension (N/NJS) ratio values and zeolite suspension mass concentrations. Experiments were conducted in a baffled reactor with the propeller at a standard off-bottom clearance. In addition to the experimental studies, numerical modelling approaches were carried out to investigate the sorption process using a transient multiphase computational fluid dynamics model and fitting selected kinetic models. The results show that an increase in zeolite mass leads to a slight increase in the NJS and consequently PJS. The impeller speed affec... [more]

This paper constructs a nonlinearly parametrized hypersonic cruise vehicle model on the basis of the existing on-orbit flight data using a curve-fitting technique. The hypersonic cruise vehicle system is separated into two interconnected subsystem: an attitude subsystem with rotational dynamics and a velocity subsystem with engine dynamics. The continuous adaptive controllers are designed for two subsystems using a novel function bounding technique and appropriate coordinate transformations, respectively, which ensure the global boundedness of all signals and achieve the non-zero equilibrium point regulation of nonlinearly parametrized hypersonic vehicle systems. One of the implications of this result is that growing nonlinearities in the uncertain model of the hypersonic vehicle system may be allowed for global stabilization. A simulation result verifies the effectiveness of the proposed adaptive control scheme.

Supply chain disruptions and challenges have and will always exist, but preparing in advance and improving resilience for the upcoming consequences should be the utmost important goal. This paper explores trends that affect innovation in the technological sphere of supply chain systems. More precisely, the research is focused on Digital Twin technology applicability through other logistics IT trends and aims to research the pressing issue of ensuring the visibility and resilience of future supply chain systems. The paper’s objective is to produce a conceptual model enabling the investment assessment of the necessary IT resources. Initially, a theoretical confirmation of logistics IT trends’ relevance to supply chain systems was established. After, propositions of Digital Twin technology applications to other logistics IT trends were made, which were divided into corresponding constant multitudes of supply chain systems. Lastly, the conceptual model for the investment assessment of the... [more]

The aldol condensation of furfural and acetone is considered a promising method for the production of liquid fuel intermediates. 4-(2-furyl)-3-buten-2-one (FAc) and 1,5-di-2-furanyl-1,4-pentadien-3-one (F2Ac) are the main products of the reaction, which can go through the hydrodeoxygenation process to convert to diesel and jet fuel range fuels. Considering the present situation at the fuel-market related to crude oil shortage, the above-mentioned process seems to be a convenient path to obtain fuels in the diesel and kerosene range. This research focuses on the effect of water on the furfural conversion and product distribution during the aldol condensation. The catalyst chosen for this research was MgAl mixed oxide in molar ratio 3:1. The reaction was performed at 40 °C and 1 MPa in a continuous-flow reactor with and without water in the feedstock. The physicochemical properties of the catalyst were evaluated using different techniques. The catalyst lifetime decreased and the catalyst... [more]

Homogeneous catalysis is relevant for biodiesel fuel synthesis; however, it has the disadvantage of difficult separation of the catalyst. In the present work, heterogeneous catalysis was applied for rapeseed oil transesterification with methanol, while snail shells were used as a catalyst. CaO content in the catalyst was investigated. Transesterification reactions were carried out in a laboratory reactor, ester yield was analyzed using gas chromatography. Response surface methodology was used for process optimization. It was found that the optimum transesterification conditions when the reaction temperature is 64 °C are the following: a catalyst amount of 6.06 wt%, a methanol-to-oil molar ratio of 7.51:1, and a reaction lasting 8 h. An ester yield of 98.15 wt% was obtained under these conditions.

In order to study the gas migration in gas-bearing coal, and reasonably arrange gas drainage boreholes to improve the efficiency of gas drainage, a gas-solid coupling model is established based on the pore-fracture dual medium porous model. The solid deformation of coal body, gas seepage and diffusion, and gas adsorption and desorption are considered in this model. The COMSOL software is used to simulate the gas change in the coal matrix and coal fracture under single borehole extraction. We analyze the effective extraction range and study the migration mechanism of gas between coal fracture and borehole, coal matrix and coal fracture, and coal matrix. The effective extraction area of multi-borehole negative pressure gas extraction varies with extraction time and borehole spacing. At 140 d, the effective extraction radius is r = 1.3 m, and the spacing of boreholes is 233 r=1.5 m, 2 r=2.6 m,4 m,5 m,and 6 m, respectively. The influence of the equilateral triangle shape of three boreholes... [more]

The collision behavior and ice formation of a water droplet are affected by its falling process. In this paper, the two-phase flow of air and a water droplet at a specific temperature is adopted to investigate the processes of falling and freezing of a single water droplet. To track the air−water droplet interface and the temperature distribution, the level-set method and the non-isothermal flow coupling method are used, and the freezing model is added into the water’s control equations. The numerical results indicated that with the initial temperature at 283.15 K and the spherical shape, the water droplet changes to the shape of a straw hat at 293.15 K and a drum at 293.15 K but an oval face in freezing temperatures at 0.10 s. There is an obvious drop in the downward velocity when the water droplet falls in mild temperatures at 0.09 s. The downward velocity of the water droplet in air at sub-zero temperatures has a continuous increase during the time span from 0 s to 0.10 s. There is... [more]

Soybean bioactivity is significantly enhanced during tempeh fermentation. This study aimed to evaluate the efficacy of tempeh on colorectal cancer cells in vitro and colon precancerous lesions (aberrant crypt foci, ACF) in vivo. In the in vitro assay, tempeh water extract (WET) could inhibit the proliferation of Caco-2 cells. In the animal assay using 1,2-dimethylhydrazine (DMH)-induced Sprague−Dawley (SD) rats, 12-weeks daily feeding of tempeh could decrease the level of Clostridium perfringens in cecum contents and reduce the number of large (≥4 foci) ACF in the colon of treated rats, compared to the DMH control. By the results of TOF-MS and Edman degradation, the isolated antioxidant dipeptide, tripeptides, and tetrapeptides from WET might contain methionine, proline, and lysine. The bioactive peptides in tempeh might inhibit colon cancer by suppressing the growth of C. perfringens in the intestinal tract.

The present investigations on sealability evaluation for tubing and casing premium connections depend on the FEM with testing. This paper proposed a theoretical model to evaluate the sealability of a sphere-type premium connection based on make-up torque, which combines Hertz contact pressure and the von Mises yield criterion for calculating elastic−plastic contact pressure distribution on sealing interface and adopts the gas sealing criterion obtained from Murtagian’s experimental results for deducing gas sealing capacity. With the proposed model, the effects of additional make-up torque from the sealing interface on the sealing contact pressure distribution and key sealability parameters, including contact width, yield width, average contact pressure and gas sealing capacity, were analyzed and compared. The results show that additional make-up torque from the sealing interface closely influenced sealability parameters’ variation and gas sealing capacity. The gas sealing index based o... [more]

To solve the trajectory planning problem of the flexible manipulator under various constraints such as end-camera attitude, drive space, and obstacles during video inspection along a continuous path in narrow three-dimensional space, this paper proposes a time-optimal trajectory planning method from the initial configuration to the final configuration. The trajectory planning problem is transformed into a multi-constraint optimization problem. First, to realize continuous video inspection in an unstructured complex environment, by analyzing the geometric model of the two-segment flexible manipulator with a camera at the end, the pose constraints between the camera and the shooting surface are formulated by the space vector method, the driving constraints are formulated based on kinematics, and the obstacle constraints are formulated by space mapping. Then, a multi-constraint optimization model is constructed to generate the smooth trajectory of the drive cable of the flexible manipulat... [more]

sp. D-23 was obtained by ultraviolet-diethyl sulfate (UV-DES) compound mutagenesis from Aspergillus sp. C18 that the α-galactosidase was purified from. According to sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and non-denaturing polyacrylamide gel electrophoresis (Native-PAGE), the purified enzyme demonstrated apparent homogeneity. The monomeric α-galactosidase’s native molecular weight was 125 kDa. The optimal temperature of α-galactosidase was 65 °C, and 75% of the initial enzyme activity could be maintained between 45 and 55 °C. Its optimal pH was 5.0 with good pH stability. After incubating for 2 h at pH 3.0−8.0, it could retain more than 80% of its original activity. Different concentrations of metal ions had different effects on the α-galactosidase activity. High concentrations of Cu2+ could strongly inhibit enzyme activity and low concentrations of Fe2+ could promote enzyme activity. Additionally, as shown by thin layer chromatography and high-performance... [more]

This study used computational fluid dynamics for low greenhouse effect refrigerant (R-513A) simulation analysis in the two-stage 150 USRT class oil-free centrifugal refrigerant compressor using integrated part load value (IPLV) and internal flow field. The compressor rotor speed and mass flow rate for the IPLV working conditions with various loads were planned using Stage 1 and Stage 2 simulations, respectively. The performance and flow field numerical simulation analyses for the two-stage centrifugal compressor is discussed. This study used Ansys-CFX software for numerical simulation analysis and the conservation form of a 3D steady-state Navier−Stokes equation set with the finite volume discretization method for computation. The computing mode produced better computing efficiency and flexible mesh setting using the k-omega (k-ω) model, which has better computational performance in the near wall boundary layer and low Reynolds number flow field (used as the turbulence model) for simul... [more]

This study was conducted in a fluidized-bed incineration plant, evaluating the formation, emission and flux of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) from industrial-organic-solid-waste (IW) incineration. The results revealed that both the total (or I-TEQ) concentrations of toxic and 136 total PCDD/Fs in flue gas (FG), fly ash (FA) and bottom ash (BA)were ramped up to a higher level than those during municipal-solid-waste (MSW) incineration. A possible explanation was the chlorine (Cl) content of IW. However, the emitted PCDD/Fs in FG (FA/BA) still fulfilled the criteria. Subsequently, similar distribution patterns of PCDD/F isomers were observed in subsystems, indicating a unified formation-pathway. De novo synthesis was detected as the dominant formation-pathway of PCDD/Fs, while high-temperature and precursor syntheses were excluded. DD/DF chlorination formed PCDD/Fs to some extent. Furthermore, the mass flow chart indicated that PCDD/Fs output in primary FG w... [more]

The stability of a quadruped robot is mainly affected by the obstacles in the horizontal direction and the roughness in the vertical direction, which often leads to the robot unable to achieve the desired gait effect. In order to solve this problem, the Model Predictive Control (MPC) model and the Zero Moment Point (ZMP) method are combined, and applied to gait planning and the foot end landing control of a small quadruped robot. The tort gait of a small quadruped robot is the focus of research in this study, which simulated trajectory planning and gait stability. In addition, through comparative analysis with the corresponding experiments, the results show that the simulation results are similar to the experimental results, and the quadruped robot gait is stable. Meanwhile, it shows that the combination of the MPC model and ZMP method is feasible for gait stability control of a quadruped robot.