Nanoscale zero-valent iron (nZVI) particles have proved to be effective in the remediation of chlorinated compounds and heavy metals from contaminated soil. The present study aimed to analyze the performance of nanoparticles synthesized from low-cost biomass (green leaves) as chemical precursors, namely Azadirachta indica (neem) and Mentha longifolia (mint) leaves. These leaves were chosen because huge amounts of them are present in the region of Vellore. These nanoparticles were used to remove lead and nickel from contaminated soil. Characterization of nZVI particles was conducted using the Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), and Brunauer−Emmett−Teller isotherm (BET) techniques. Remediation was performed on two different soil samples, polluted with lead or nickel at an initial metal concentration around 250 mg/kg of soil. The results revealed that after 30 days, the lead removal efficiency with 0.1 g of nZVI particles/kg of soil was 26.9% by par... [more]

Traditional beers, such as palm wine, kombucha and others, are notable beverages consumed all over the globe. Such beverages historically contribute to food security on a global scale. Umqombothi is a South African traditional beer nutritionally packed with minerals, amino acids, B-group vitamins and much-needed calories. As a result, the production and consumption of this traditional beverage has been an integral part of South African’s social, economic and cultural prosperity. Unfortunately, difficulties in bioprocessing operations have limited its availability to household and small-scale production. It is at these micro-production scales that poor hygiene practices and the use of hazardous additives and contaminated raw materials continue to increase, posing serious health risks to the unassuming consumer. This study provides an overview of the processing steps and underlying techniques involved in the production of umqombothi, while highlighting the challenges as well as future de... [more]

The present study was designed to evaluate the effect of hydroxyl propyl methyl cellulose (HPMC) on the complexation efficiency and dissolution of piperine (PPR) and β cyclodextrin (β CD) complex. The binary and ternary inclusion complexes were prepared using solvent evaporation and microwave irradiation methods. The samples were further evaluated for physicochemical evaluation, morphology, antimicrobial, and antioxidant activities. The binary and ternary samples showed high stability constant (Ks) value and complexation efficiency (CE). The dissolution study results revealed marked enhancement in the release of the binary inclusion complex and ternary inclusion complex compared to pure PPR. Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), and molecular docking results confirm the complex formation. X-ray powder diffractometry (XRD) and scanning electron microscopy (SEM) data revealed modification in the structure of PPR. 2,2-diphenyl-1-picrylhydrazyl (DPPH) scaveng... [more]

Improved productivity of the two most commonly used cell lines in the biopharmaceutical industry, such as human embryonic kidney 293 (HEK293) and Chinese hamster ovary (CHO), could reduce production costs and increase manufacturing capacity. One method for increasing protein productivity is the addition of antioxidants during the cell culture process. In this study, we examined the effect of sialic acid (SA) on one HEK293 cell line and two CHO cell lines. The addition of SA to HEK293 cell led to a higher viable cell density (VCD), viability (Via), and a lower lactate content in the later stage of cultures. Further results showed that SA reduced the reactive oxygen species (ROS), improved cell viability, reduced lactate production, and increased antibody expression by more than 20% in the later stage of the two CHO cell lines cultures. Besides, an optimized dose of SA had no significant effect on acidic variants level aggregation level, N-linked glycosylation pattern, and SA content on... [more]

In petroleum, geological and environmental science, flow through porous media is conventionally studied complementarily with numerical modeling/simulation and experimental corefloods. Despite advances in numerical modeling/simulation, experimental corefloods with actual samples are still desired for higher-specificity testing or more complex mechanistic studies. In these applications, the lack of advances in physical modeling is very apparent with the available options mostly unchanged for decades (e.g., sandpacks of unconsolidated packing materials, industry-accepted substitutes with fixed/mismatching petrophysical properties such as Berea sandstone). Renewable synthetic porous media with adjustable parameters are the most promising but have not advanced adequately. To address this, a methodology of advanced physical modeling of the fundamental parameters of dominant mineralogy, particle size distribution, packing, and cementation of a target natural porous media is introduced. Based... [more]

Heat (HAE)- and ultrasound (UAE)-assisted extraction methods were implemented to recover anthocyanins from red raspberry. Processing time, ethanol concentration, and temperature or ultrasonic power were the independent variables combined in five-level rotatable central composite designs coupled with response surface methodology (RSM) for processes optimization. The extraction yield and levels of cyanidin-3-O-sophoroside (C3S) and cyanidin-3-O-glucoside (C3G) were monitored by gravimetric and HPLC-DAD-ESI/MSn methods, respectively, and used as response criteria. The constructed theoretical models were successfully fitted to the experimental data and used to determine the optimal extraction conditions. When maximizing all responses simultaneously, HAE originated slightly higher response values (61% extract weight and 8.7 mg anthocyanins/g extract) but needed 76 min processing at 38 °C, with 21% ethanol (v/v), while the UAE process required 16 min sonication at 466 W, using 38% ethanol (v... [more]

The degradation of imazapyr (C13H15N3O3), an active element in the aqueous solution of commercial herbicide, was investigated. This study was the first to evaluate in a comprehensive manner the efficiency of advanced oxidation processes for imazapyr degradation. Results showed that Imazapyr degradation is significantly affected by operational conditions such as TiO2 concentration, ozone concentration, initial concentration of imazapyr and pH. The kinetics of Imazapyr consumption was the first order with respect to Imazapyr concentration and zero order with respect to ozone concentration with a constant rate of 0.247 min−1 and 0.128 min−1 for photocatalytic ozonation and heterogeneous photocatalysis, while it was the first order with respect to Imazapyr and the first order with respect to ozone concentrations when only ozone was used with a constant rate of 0.053 mol L−1 min−1 at pH 7. The results revealed that more than 90 percent of the removal efficiency representing the elimination... [more]

This paper studies the influence of tip clearance on the flow characteristics related to the performance. Based on full-passage numerical simulation with experimental validation, several clearance models are established and the performance curves are obtained. It is found that there exists an optimum clearance for the stable working range. By analyzing the flow field in tip region, the role of the tip leakage flow is illustrated. In the zero-clearance model, the separation and blockage along the suction side is the main reason for rotating stall. As the tip clearance is increased to the optimum value, the separation is suppressed by the tip leakage flow. However, with the continuing increasing of the tip clearance, the scale and strength of the tip clearance vortex is increased correspondingly. When the tip clearance is larger than the optimum value, the tip clearance vortex gradually dominates the flow field in the tip region, which can increase the unsteadiness in the tip region and... [more]

This study investigated the effect of adding two sister holes placed downstream the main hole on film cooling by employing large eddy simulation. Here, film-cooling flow fields from a triple-hole system inclined by 35° to a flat plate at blowing ratios of M = 0.5 and unity were simulated. Each sister hole supplies a cooling fluid at a flow rate that is a quarter of that for the main hole. The simulations were conducted using the Smagorinsky−Lilly model as the subgrid-scale model, and the results were compared with those for a single-hole system for the same amount of total cooling air and same cross-sectional area of the holes. Relative to the single-hole system, the spanwise-averaged film-cooling effectiveness in the triple-hole configuration at M = 1.0 increased by as much as 345%. The subsequent proper orthogonal decomposition analysis showed that the kinetic energy of a counter-rotating vortex pair in the triple-hole system dropped by 30−40% relative to that of the single-hole syst... [more]

This numerical investigation intends to present the impact of nanoparticles volume fraction, Casson, and magnetic force on natural convection in the boundary layer region of a horizontal cylinder in a Casson nanofluid under constant heat flux boundary conditions. Methanol is considered as a host Casson fluid. Graphite oxide (GO), single and multiple walls carbon nanotubes (SWCNTs and MWCNTs) nanoparticles have been incorporated to support the heat transfer performances of the host fluid. The Keller box technique is employed to solve the transformed governing equations. Our numerical findings were in an excellent agreement with the preceding literature. Graphical results of the effect of the relevant parameters on some physical quantities related to examine the behavior of Casson nanofluid flow were obtained, and they confirmed that an augmentation in Casson parameter results in a decline in local skin friction, velocity, or temperature, as well as leading to an increment in local Nusse... [more]

Melt electrohydrodynamic processes, in conjunction with a moveable collector, have promising engineered tissue applications. However, the residual charges within the fibers deteriorate its printing fidelity. To clarify the mechanism through which the residual charges play roles and exclude the confounding effects of collector movement, a stationary printing mode is adopted in which fibers deposit on a stationary collector. Effects of process parameters on generalizable printing outcomes are studied herein. The fiber deposit bears a unique shape signature typified by a central cone surrounded by an outer ring and is characterized by a ratio of its height and base diameter Hdep/Ddep. Results indicate Hdep/Ddep increases with collector temperature and decreases slightly with voltage. Moreover, the steady-state dynamic jet deposition process is recorded and analyzed at different collector temperatures. A charge-based polarization mechanism describing the effect of collector temperature on... [more]

The geometry of volute tongue is crucial in the design of Sirocco fans. The size of the volute tongue determines its relative position and distance from the impeller which affects the local flow characteristics and thus the aerodynamic and aeroacoustic performances of the fan. In this work, we performed experimental and numerical investigations on the effect of volute tongue radius on the aerodynamic and aeroacoustic characteristics of a Sirocco fan. The internal flow characteristics are analyzed and discussed in terms of the spatial distribution and temporal variation of pressure and streamlines, the pulsating behaviors of pressure both in the impeller and on the volute surface with emphasis in the volute tongue region, the variation of passage flow with the rotation of impeller and the aeroacoustic features of the fan. We conducted numerical simulations using both steady Reynolds-Averaged Navier-Stokes (RANS) and unsteady Reynolds-Averaged Navier-Stokes (URANS) approaches with realiz... [more]

Jujube plant is a potential source of polyphenols with biological propreties. The purpose of this study was to investigate the application of ultrasound technique for extracting phenolic compounds (TPC) from seeds of Zizyphus lotus under optimization conditions based on response surface methodology. A maximum TPC, total flavonoids content (TFC), and total condensed tannins content (TTC) of 2383.10 ± 0.87 mg GAE/100g, 486.50 ± 0.38 mg QE/100g and 15,787.10 ± 0.10 mg CE/100g, respectively obtained under ethanol concentration 50.16%, sonication temperature 29.01 °C, sonication time 15.94 min and solvent-to-solid ratio 34.10:1 mL/g. The optimized extract was then evaluated for its antioxidant, antiacethylcholinesterase, antihypercholesterolemia, and antiproliferative activities. The results showed that ultrasound method is a green and safe method that can be used to effectively extract TPC from jujube seeds. The biological activity of Zizyphus extract exhibited a very good antioxidant agai... [more]

Controlling ice nucleation during lyophilization of parenteral drug products increases the homogeneity of critical quality attributes, such as residual moisture, across drug product batches and shortens lyophilization cycle time. In the present study, we compare three mechanistically different techniques to control ice nucleation during the freezing step of lyophilization, which are referred to as “depressurization”, “partial vacuum”, and “ice fog” techniques. The techniques are compared with respect to their operational limitations and challenges. Installation considerations are also discussed. Using the aforementioned nucleation techniques, we investigated a monoclonal antibody formulation and an enzyme formulation at different protein concentrations using feasible nucleation temperatures and different vial formats and fill volumes. Samples were compared for solid state properties and other critical quality attributes on stability. When nucleated at the same temperature, the three te... [more]

Carbon cap-and-trade and carbon offsets are common and important carbon emission reduction policies in many countries. In addition, carbon emissions from business activities can be effectively reduced through specific capital investments in green technologies. Nevertheless, such capital investments are costly and not all enterprises can afford these investments. Therefore, if all members of a supply chain agree to share the investments in the facilities, the supply chain can reduce carbon emissions and generate more profit. Under carbon cap-and-trade and carbon tax policies, this study proposes a production−inventory model in which the buyer and vendor in the integrated supply chain agree to co-invest funds to reduce carbon emissions. We planned to integrate production, delivery, replenishment, and technology to reduce carbon emissions so as to maximize the total profit of the supply chain system. Several examples are simulated and the sensitivity analysis of the main parameters is car... [more]

Pyrolysis of pine wood sawdust was carried out using microwave-heating technology in the presence of activated carbon (AC). Experimental conditions were of 20 min processing time, 10 wt.% of AC, and a microwave power varying from 100 to 800 W. The results obtained showed that the microwave absorber allowed increasing the bio-oil yield up to 2 folds by reducing the charcoal fraction. The maximum temperature reached was 505 °C at 800 W. The higher heating values (HHV) of the solid residues ranged from 17.6 to 30.3 MJ/kg. The highest HHV was obtained for the sample heated at 800 W with 10 wt.% of AC, which was 33% higher than the non-charged sample heated at the same power. Furthermore, the addition of AC allowed showing the probable catalytic effect of the AC in the charged sample pyrolysis bio-oils.

Chemical processes often exhibit nonlinear dynamics and tend to generate complex state trajectories, which present challenging operational problems due to complexities such as output multiplicity, oscillation, and even chaos. For this reason, a complete knowledge of the static and dynamic nature of these behaviors is required to understand, to operate, to control, and to optimize continuous stirred tank reactors (CSTRs). Through nonlinear analysis, the possibility of output multiplicity, self-sustained oscillation, and torus dynamics are studied in this paper. Specifically, output multiplicity is investigated in a case-by-case basis, and related operation and control strategies are discussed. Bifurcation analysis to identify different dynamic behaviors of a CSTR is also implemented, where operational parameters are identified to obtain self-oscillatory dynamics and possible unsteady-state operation strategy through designing the CSTR as self-sustained periodic. Finally, a discussion on... [more]

As an important water conservancy project, it is necessary to evaluate its water supply benefit. Based on the emergy analysis theory, a reservoir water supply benefits evaluation model (RWSBEM) was established. Firstly, the emergy transformity of natural and engineering water body was calculated. Secondly, the water resource values (WRV) of different water users (industrial, agricultural, domestic, ecological) were calculated. Finally, combined with the water supply situation of the reservoir, the various water supply benefits of the reservoir were calculated. Taking Hekoucun reservoir as an example, its ecological water supply benefit is the largest and agriculture is the smallest, followed by industry and life. The results showed that the trend of WRV was domestic > industry > ecology > agriculture, which reflected the contribution and utility of water resources in different industries. Under the condition of current water resources, the planned water supply benefits of the reservoir... [more]

The limited shelf life of carbon prepreg waste (CPW) from component manufacturing restricts its use as a composite reinforcement fibre on its own. However, CPW can be recycled with glass fibre (GF) reinforcement to develop a unique remediate material. Therefore, this study fabricated (1) a glass fibre-carbon prepreg waste reinforced polymer hybrid composite (GF-CPW-PP), (2) a polypropylene composite (PP), (3) a carbon prepreg waste reinforced composite (CPW-PP), and (4) a glass fibre reinforced composite (GF-PP) and reported their degradation and residual tension properties after immersion in water. The polymer hybrid composites were fabricated via extrusion technique with minimum reinforce glass-carbon prepreg waste content of 10 wt%. The immersion test was conducted at room temperature using distilled water. Moisture content and diffusion coefficient (DC) were determined based on water adsorption values recorded at 24-h intervals over a one-week period. The results indicated that GF-... [more]

Ultraviolet-C radiation and ultrasound technology are widely accepted and continuously being appraised as alternatives to conventional thermal techniques for decontamination of fruits and vegetables. However, studies in these areas have presented challenges related to quality, safety, limited capability, and cost of energy. This review paper presents an up-to-date summary of applications of ultraviolet-C radiation and ultrasound technology for postharvest handling of fruits and vegetables from relevant literature. The limitations associated with applications of ultraviolet-C radiation and ultrasound technology individually has prompted their combination alongside other antimicrobial strategies for enhanced bactericidal effect. The combination of ultraviolet-C radiation and ultrasound technology as a hurdle approach also provides enhanced efficiency, cost effectiveness, and reduced processing time without compromising quality. The review includes further scope of industrial-led collabor... [more]

This paper provides a fundamental and critical review of biomass application as renewable reductant in integrated ferroalloy reduction process. The basis for the review is based on the current process and product quality requirement that bio-based reductants must fulfill. The characteristics of different feedstocks and suitable pre-treatment and post-treatment technologies for their upgrading are evaluated. The existing literature concerning biomass application in ferroalloy industries is reviewed to fill out the research gaps related to charcoal properties provided by current production technologies and the integration of renewable reductants in the existing industrial infrastructure. This review also provides insights and recommendations to the unresolved challenges related to the charcoal process economics. Several possibilities to integrate the production of bio-based reductants with bio-refineries to lower the cost and increase the total efficiency are given. A comparison of chall... [more]

Fruits and vegetables are highly nutritious agricultural produce with tremendous human health benefits. They are also highly perishable and as such are easily susceptible to spoilage, leading to a reduction in quality attributes and induced food loss. Cold chain technologies have over the years been employed to reduce the quality loss of fruits and vegetables from farm to fork. However, a high amount of losses (≈50%) still occur during the packaging, pre-cooling, transportation, and storage of these fresh agricultural produce. This study highlights the current state-of-the-art of various advanced tools employed to reducing the quality loss of fruits and vegetables during the packaging, storage, and transportation cold chain operations, including the application of imaging technology, spectroscopy, multi-sensors, electronic nose, radio frequency identification, printed sensors, acoustic impulse response, and mathematical models. It is shown that computer vision, hyperspectral imaging, m... [more]

To reveal quality change rules and establish the predicting model of konjac vacuum drying, a response surface methodology was adopted to optimize and analyze the vacuum drying process, while an artificial neural network (ANN) was applied to model the drying process and compare with the response surface methodology (RSM) model. The different material thickness (MT) of konjac samples (2, 4 and 6mm) were dehydrated at temperatures (DT) of 50, 60 and 70 °C with vacuum degrees (DV) of 0.04, 0.05 and 0.06 MPa, followed by Box−Behnken design. Dehydrated samples were analyzed for drying time (t), konjac glucomannan content (KGM) and whiteness index (WI). The results showed that the DT and MT should be, respectively, under 60 °C and 4 mm for quality and efficiency purposes. Optimal conditions were found to be: DT of 60.34 °C; DV of 0.06 MPa and MT of 2 mm, and the corresponding responses t, KGM and WI were 5 h, 61.96% and 82, respectively. Moreover, a 3-10-3 ANN model was established to compare... [more]

In general, the performance of a direction of arrival (DOA) estimator may decay under a non-uniform noise and low signal-to-noise ratio (SNR) environment. In this paper, a memetic particle swarm optimization (MPSO) algorithm combined with a noise variance estimator is proposed, in order to address this issue. The MPSO incorporates re-estimation of the noise variance and iterated local search algorithms into the particle swarm optimization (PSO) algorithm, resulting in higher efficiency and a reduction in non-uniform noise effects under a low SNR. The MPSO procedure is as follows: PSO is initially utilized to evaluate the signal DOA using a subspace maximum-likelihood (SML) method. Next, the best position of the swarm to estimate the noise variance is determined and the iterated local search algorithm to reduce the non-uniform noise effect is built. The proposed method uses the SML criterion to rebuild the noise variance for the iterated local search algorithm, in order to reduce non-un... [more]

Temperature control systems are a series of processes with large time-delay and non-linear characteristics. Research shows that using fractional-order modeling and corresponding control strategies can better control these processes. At the same time, the existing studies for control performance assessment are almost committed to the integer order control systems, and the methods used in few literatures on performance assessment of fractional order systems are also one-sided. This paper applies the linear quadratic Gaussian (LQG) evaluation benchmark to the performance evaluation of fractional-order control systems for the first time, starting with the LQG evaluation benchmark considering the input and output performance. The LQG benchmark can be obtained by the analytical algorithm, which simplifies the complexity of LQG solution. Finally, taking the application of the fractional predictive function control (FO-PFC) controller in the experiment of industrial heating furnace temperature... [more]