A novel hydrocyclone including a cylindrical screen embedded in a conventional hydrocyclone (CH), named three products hydrocyclone screen (TPHS), has been successfully designed. In TPHS, the combination of centrifugal classification and screening was employed to separate particles. In this paper, Grey theory, as an effective means to the laws of both complex and uncertainty system’s behavior with small samples, was used to investigate the operational (feed concentration and feed pressure) and structural (aperture size, spigot diameter, and vortex finder diameter) parameters on performance evaluation Hancock classification efficiency (HE), imperfection (I), and cut size (d50c). The experiments of coal sample (0−1 mm) show that TPHS with coarser particles in underflow exhibited the absent “fish-hook”. The closeness calculated using the Grey System algorithm indicates that the performance of TPHS was closely related to the operation and structure parameters. Further, the order of grey in... [more]

As a new type of suspension bearing, Magnetic-Liquid Double Suspension Bearing (MLDSB) is mainly supported by electromagnetic suspension and supplemented by hydrostatic supporting. Its bearing capacity and stiffness can be greatly improved. Because of the small liquid film thickness (it is smaller 10 times than air gap), the eccentricity, crack, bending of the rotor, and the assembly error, it is easy to cause a clearance-rubbing fault between the rotor and stator. The coating can be worn and peeled, the operating stability can be reduced, and then it is one of the key problems of restricting the development and application of MLDSB. Therefore, the clearance-rubbing dynamic equation of 2-DOF system of MLDSB is established and converted into Taylor Series form and the nonlinear components are retained. Dimensionless treatment is carried out by dimensional normalization method. Finally, the rotor displacement response under different rotor eccentricity ratio and rotating speeds is numeri... [more]

In this study, the effect of fracturing fluid on the permeability of tight oil reservoirs is analyzed through oil absorption. The mechanism of permeation and absorption in tight oil reservoirs was studied using the molecular dynamics simulation of fluid flow through fractures in porous media containing crude oil. The influence of surfactants on the adsorption characteristics of crude oil formations on rock walls was also examined. The research results show that the introduction of the appropriate surfactant to the fracturing fluid could accelerate the rate of percolation and recovery as well as improve the recovery rate of absorption. The optimal concentration of polyoxyethylene octyl phenol ether-10 (OP-10) surfactant in the fracturing fluid was 0.9%. When the percolation reached a certain stage, the capillary forces in the crude oil and percolation medium in the pore stabilized; accordingly, the crude oil from the pore roar should be discharged at the earliest. The fluid flow through... [more]

The design of a desalination plant is most important if the desired product purity has to be as high as possible. This is also true for freeze crystallization plants. A correct solid-to-liquid ratio has to be ensured when pressing is used as a post-treatment. Thus, the dependence of the overall plant design on the achieved ice quality but also on different hydraulic and thermodynamic numbers is important. In this research, a scraped screw crystallizer plant is presented and examined for two different screw designs. Experiments with a low initial concentration, as for the usage to desalinate groundwater to gain it as process water, were conducted. Furthermore, solutions with high initial concentrations simulating seawater to produce potable water were used as another set of test solutions. The findings showed that neither of the screw designs is more favorable than the other, but it is important to have a plant design fitting the existing parameters on site.

Low aqueous solubility and poor bioavailability of curcumin have limited its application in various fields. One approach to address this issue is to formulate a nanosuspension that incorporates curcumin, which has been previously shown to exhibit remarkably improved solubility in comparison with that of a bare compound. In this study, the preparation process of curcumin nanosuspension was optimized with a median particle size as the outcome. Gum arabic was used as a natural polymeric surfactant and the suspension was formulated using high speed homogenization. Optimization results, realized via a response surface methodology, showed that a minimum median particle size (8.524 µm) could be attained under the following conditions: curcumin:gum arabic ratio of 1:6 g/g; homogenization speed of 8300 rpm and homogenization time of 40 min. Under these conditions, the particle size of obtained suspension was shown to be consistent for around seven days without major aggregation. The homogenizat... [more]

Biotransformation of fatty acids from renewable wastewater as feedstock to value-added chemicals is a fascinating commercial opportunity. α,ω-Dicarboxylic acids (DCAs) are building blocks in many industries, such as polymers, cosmetic intermediates, and pharmaceuticals, and can be obtained by chemical synthesis under extreme conditions. However, biological synthesis can replace the traditional chemical synthesis using cytochrome P450 enzymes to oxidize fatty acids to DCAs. Saccharomyces cerevisiae BY(2R)/pYeDP60-CYP52A17SS (BCM), a transgenic strain expressing the galactose-inducible CYP52A17SS cytochrome P450 enzyme, was able to grow in a coconut milk factory wastewater (CCW) medium and produced 12-hydroxydodecanoic acid (HDDA) and 1,12-dodecanedioic acid (DDA). The supplementation of CCW with 10 g/L yeast extract and 20 g/L peptone (YPCCW) markedly increased the yeast growth rate and the yields of 12-HDDA and 1,12-DDA, with the highest levels of approximately 60 and 38 µg/L, respecti... [more]

There is a growing interest in a fluidized bed particle receiver that directly irradiates sunlight to particles in the fluidized bed as a solar thermal collector for heating. Thermal performance of directly-irradiated fluidized bed gas heater is strongly affected by the physical properties of the particles. The effect of SiC particle size on heat transfer characteristics in the solar fluidized bed gas heater (50 mm-ID × 100 mm high) has been determined. The outlet gas temperatures showed a maximum value with increasing gas velocity due to the particles motion by bubble behavior in the bed, and the maximum values were found at 3.6 times of Umf for fine SiC and less than 2.0 times of Umf for coarse SiC. Heat absorption from the receiver increased with increasing gas velocity, showing with maximum 18 W for the fine SiC and 23 W for the coarse SiC at 4.5 times of Umf. The thermal efficiency of the receiver increased with increasing gas velocity, but was affected by the content of finer par... [more]

Hydrogen cyanide (HCN)-derived polymers have been recognized as sources of relevant organic molecules in prebiotic chemistry and material sciences. However, there are considerable gaps in the knowledge regarding the polymeric nature, the physicochemical properties, and the chemical pathways along polymer synthesis. HCN might have played an important role in prebiotic hydrothermal environments; however, only few experiments use cyanide species considering hydrothermal conditions. In this work, we synthesized an HCN-derived thermal polymer simulating an alkaline hydrothermal environment (i.e., HCN (l) 0.15 M, 50 h, 100 °C, pH approximately 10) and characterized its chemical structure, thermal behavior, and the hydrolysis effect. Elemental analysis and infrared spectroscopy suggest an important oxidation degree. The thermal behavior indicates that the polymer is more stable compared to other HCN-derived polymers. The mass spectrometric thermal analysis showed the gradual release of severa... [more]

According to reports published, the aberrant expression of microRNAs (miRNAs), a class of 19−25 nucleotide-long small non-coding RNAs, is responsible for human cancers, including nasopharyngeal cancer (NPC). The dysregulation of miRNAs that act either as a tumor suppressor or oncogene, leading to a wide range of NPC pathogenesis pathways, includes the proliferation, invasion, migration as well as the metastasis of NPC cells. This article reviews and highlights recent advances in the studies of miRNAs in NPC, with a specific demonstration of the functions of miRNA, especially circulating miRNAs, in the pathway of NPC pathogenesis. Additionally, the possible use of miRNAs as early screening and prognostic biomarkers and for therapeutic molecular monitoring has been extensively studied.

As-synthesized oleic amido propyl betaine surfactant mixture was developed through a slight modification of a conventional two-step betaine synthesis process of amidation and quaternization reactions. This method is a “direct formulating through synthesis” to achieve a targeted interfacial property (interfacial tension or IFT) of the as-synthesized surfactant. Oil−water IFT was measured in the crude oil−seawater system at 96 °C. The result showed that the as-synthesized surfactant was able to reduce crude oil−seawater IFT to the ultra-low level (<0.01 mN/m). As the finding emerged, the investigation was conducted to identify the elements that would bring the characteristic of ultra-low IFT. The characterization of the surfactant using FTIR, TG-IR, and HPLC suggested that unreacted materials associated with the surfactant remained, such as the carryover of a fatty amide from the intermediate process, residues of N, N trimethylene dimethylamine and sodium chloride as a by-product, and... [more]

The productivity of the capacitive deionization (CDI) system is enhanced by determining the optimum operational and structural parameters using radial movement optimization (RMO) algorithm. Six different parameters, i.e., pool water concentration, freshwater recovery, salt ion adsorption, lowest concentration point, volumetric (based on the volume of deionized water), and gravimetric (based on salt removed) energy consumptions are used to evaluate the performance of the CDI process. During the optimization process, the decision variables are represented by the applied voltage, capacitance, flow rate, spacer volume, and cell volume. Two different optimization techniques are considered: single-objective and multi-objective functions. The obtained results by RMO optimizer are compared with those obtained using a genetic algorithm (GA). The results demonstrated that the RMO optimization technique is useful in exploring all possibilities and finding the optimum conditions for operating the... [more]

Building a biologic model that describes the behavior of a cell in biologic systems is aimed at understanding the physiology of the cell, predicting the production of enzymes and metabolites, and providing a suitable data that is valid for bio-products. In addition, building a kinetic model requires the estimation of the kinetic parameters, but kinetic parameters estimation in kinetic modeling is a difficult task due to the nonlinearity of the model. As a result, kinetic parameters are mostly reported or estimated from different laboratories in different conditions and time consumption. Hence, based on the aforementioned problems, the optimization algorithm methods played an important role in addressing these problems. In this study, an Enhanced Segment Particle Swarm Optimization algorithm (ESe-PSO) was proposed for kinetic parameters estimation. This method was proposed to increase the exploration and the exploitation of the Segment Particle Swarm Optimization algorithm (Se-PSO). The... [more]

The purpose of the work was to develop such chromatographic conditions that allowed to separate as many naproxen degradation products as possible. In order to follow this process, thin-layer chromatography (TLC) coupled with densitometry and spectrodensitometry was used. A forced degradation study was performed using an ethanolic solution of naproxen spotted on silica gel plates, existing in the form of an aqueous solution at various pH values, and as solution prepared in saline and in hydrogen peroxide. Degradative effect of UV light on naproxen was watched in the context of naproxen spotted on plates precoated with silica gel and exposed to UV light, and also for its solution treated with UV light. However, the solution of naproxen prepared in water at pH ≈ 2.60 undergoes the largest changes as the results of its exposure to UV light during 10 h. Stressed samples of naproxen were analyzed by using a new and well validated TLC procedure including toluene (TOL)—acetone (ACE)—chloroform... [more]

Stretchable and flexible graphite films can be effectively applied as functional layers in the progressively increasing field of stretchable and flexible electronics. In this paper, we focus on the feasibility of making stretchable and flexible films based on expanded graphite particles on a polymeric substrate material, polydimethylsiloxane (PDMS). The expanded graphite particles used in this work are prepared by utilizing bath sonication processes at the ultrasonic frequency of either the commercially available graphite flakes or graphite particles obtained through electrolysis under the interstitial substitution of silver and sulfate, respectively. The X-ray diffraction (XRD) patterns confirm that, due to the action of the bath sonication intercalation of graphite taking place, the resistances of the as-fabricated thin films is ultimately lowered. Mechanical characterizations, such as stretchability, flexibility and reliability tests were performed using home-made tools. The films w... [more]

This paper develops a two-stage stochastic mixed integer linear programming model to optimize Carbon Capture, Utilization and Storage (CCUS) supply chains in Italy, Germany and the UK. Few works are present in the literature about this topic, thus this paper overcomes this limitation considering carbon supply chains producing different products. The objective of the numerical models is to minimize expected total costs, under the uncertainties of the production costs of carbon-dioxide-based compounds. Once carbon dioxide emissions that should be avoided are fixed, according to environmental protection requirements for each country, the optimal design of these supply chains is obtained finding the distribution of carbon dioxide captured between utilization and storage sections, the amount of different carbon-based products and the best connection between each element inside the system. The expected total costs for the CCUS supply chain of Italy, Germany and the UK are, respectively, 77.3... [more]

The torrefaction of three representative types of biomass—bamboo, and Douglas fir and its bark—was carried out in a cylindrical-shaped packed bed reactor under nitrogen flow at 573 K of the reactor wall temperature. As the thermal energy for the torrefaction was supplied from the top and the side of the bed, the propagation of the temperature profile of the bed is a crucial factor for discussing and improving the torrefaction reactor performance. Therefore, the temperature and gas flow rate (vector) profiles throughout the bed were calculated by model simulation so as to scrutinize this point. The measured temperature at a certain representative location (z = 30 mm and r = 38 mm) of the bed was well reproduced by the simulation. The volume faction of the bed at temperatures higher than 500 K at 75 min was 0.89, 0.85, and 0.99 for bamboo, and Douglas fir and its bark, respectively. It was found that the effective thermal conductivity is the determining factor for this difference. The he... [more]

Based on Shear Stress Transport (SST) turbulence model for unsteady simulation of an axial-flow fan, this paper studies the time-frequency information in the hump region, and investigates the disturbance information of spike and modal wave under different flow coefficients based on continuous wavelet transform (CWT). The results show that before the hump point, the low-frequency modal wave occupies the main disturbance form and circularly propagates at 1/10 of the rotor speed, and the axial-flow fan does not enter the stall stage; while after the flow coefficient reduces to the hump point, the spike wave with higher frequency replaces the modal wave as the main disturbance mode while the axial-flow fan enters the stall stage. Through in-depth investigation of unsteady flow characteristics under the hump point, it is found that after experiencing the emerging spike, with the sharp increase of incidence angle, some flow distortions appear on the intake surface, and further induce some fl... [more]

Uniaxial loading and organic solvent are small-scale oil expression methods used to evaluate the mechanical behavior, oil content, and oil efficiency of oil-bearing materials aimed at designing a low-cost mechanical pressing system. Bulk kernels of pressing height 40 mm were heated from 40 to 60 °C and compressed at maximum force of 60 kN and speeds from 4 to 8 mm/min. Relaxation times between 3 and 12 min were applied to assess the kernel oil efficiency. The kernel oil point was identified at deformation levels between 15 and 25 mm at a speed of 4 mm/min using a litmus test. The kernel oil was analyzed for peroxide value and free fatty acid. Kernel oil content was determined by Soxhlet extraction. Increased speed caused a serration effect on the force−deformation curve leading to lower oil yield. Lower and upper oil point forces at 6.21 ± 0.58 and 10.61 ± 0.71 kN were observed to be useful for predicting the pressure for maximum output oil. The peroxide value and free fatty acid conte... [more]

The homogenization of the agitated batch and ensuring the suspension of particles are the most frequently encountered requirements in terms of mixing applications. These operations are affected by the flow of the agitated batch. The geometrical parameters of the mixing system, especially the shape of the agitator blade, affect flow and circulation in the agitated batch. The present work provides a general description of the most common processes in the agitated batch (blending and particle suspension), hydrodynamic parameters (flow in agitated batches, pumping and circulation capacity of impellers) and the geometrical configurations of the mixing equipment (shape of vessel, baffle and impeller, and their mutual arrangement) that influence the process. The dimensionless process characteristics of the agitator were derived by theoretical analysis. These characteristics were applied to evaluate an extensive set of experimental data with various geometric configurations of the mixing equip... [more]

Many plant materials, such as fruits and vegetables as well as herbs and spices, represent valuable sources of antioxidants. In recent years, wastes from agriculture and food industrial processes have been shown to be interesting sources for bioactive compound recovery, strongly contributing to the circular economy. Nowadays, because of their possible adverse effects on human health, there is a tendency to replace synthetic antioxidants with natural compounds. This review attempts to critically summarize the current evidence on plant bioactives, extracted from food or waste, added to unsaturated vegetable oils, in order to obtain high added-value products and to ameliorate their oxidative stability and shelf life. The goal of this review is to demonstrate the current status of the research on edible oils added with natural plant bioactives, highlighting new approaches in the field of health-promoting foods.

Manufacturing-based carbon fibre-reinforced polymer (CFRP) and glass fibre-reinforced polymer (GFRP) wastes (pre-consumer waste) were recycled to recover valuable carbon fibres (CFs) and glass fibres (GFs), utilising a novel thermal recycling process with a cone calorimeter setup. The ideal conditions to recycle both the fibres occurred at 550 °C in atmospheric pressure. The processing time in the batch reactor to recycle CFs was 20−25 min, and to recycle GFs it was 25−30 min. The recovery rate of the recycled CFs was 95−98 wt%, and for GFs it was 80−82 wt%. Both the recycled fibres possessed a 100−110 mm average length. The resin phase elimination was verified by employing scanning electron microscopy (SEM). Furthermore, the fibres were manually realigned, compression moulded at room temperature, and cured for 24 h by a laminating epoxy resin system. The newly manufactured CFRP and GFRP composites were continuous (uniform length from end to end), unidirectionally oriented (0°), and no... [more]

During the voyage of a ship, the performance of a controllable pitch propeller (CPP) is severely affected by the changing load demand and ever-present disturbance from ocean waves, which will also result in model uncertainty. In order to improve the performance of the CPP system, an online high-performance genetic algorithm (HPGA)-based sliding mode control (SMC) strategy is proposed. Firstly, the model of the CPP system is obtained according to the manufacturer’s instructions. Then, a chattering-free sliding mode controller (CF-SMC) is designed for the CPP system, after which the parameters in the CF-SMC are optimized with the HPGA method. Finally, the optimized CF-SMC is applied to an experimental setup of a prototype CPP system. In order to validate the effectiveness of the proposed method, it is compared with a proportional-integral-derivative (PID) controller, which is typically applied on real CPP-systems, with results indicating the superiority of the proposed method.

The optimization of production cost has always been a key issue in manufacturing systems; for the single product type manufacturing systems, lots of research studies have proved the validity of the hedging point control policy in production cost control. However, due to the complexity of the multiple machines and multiple product types manufacturing systems with uncertain fault, it is difficult to achieve a good control effect only by using the hedging point control policy. To optimize the total production cost under constantly changing demands, an integrated control policy that combines the prioritized hedging point (PHP) control policy with the production capacity planning during production is proposed, and the decision variables are obtained by a particle swarm optimization (PSO) algorithm. The simulation experiments show the effectiveness of the proposed integrated control policy in production cost control for the multiple machines and multiple product types manufacturing system.

In the past few decades, we have witnessed tremendous advancements in biology, life sciences and healthcare. These advancements are due in no small part to the big data made available by various high-throughput technologies, the ever-advancing computing power, and the algorithmic advancements in machine learning. Specifically, big data analytics such as statistical and machine learning has become an essential tool in these rapidly developing fields. As a result, the subject has drawn increased attention and many review papers have been published in just the past few years on the subject. Different from all existing reviews, this work focuses on the application of systems, engineering principles and techniques in addressing some of the common challenges in big data analytics for biological, biomedical and healthcare applications. Specifically, this review focuses on the following three key areas in biological big data analytics where systems engineering principles and techniques have be... [more]

The height of water-conducting fracture zones (WCFZs) is vital for the prevention of water, gas, and roof accidents in coal mines. However, its dynamic evolution law and maximum height are difficult to be obtained by traditional prediction methods, especially for conditions in which there is high overburden caving strength and a thick coal seam. Therefore, taking the 150,313 fully mechanized caving working face in Yingying Coal Mine as a background, according to the principle of optimized processes, a new predicting approach based on the Brillouin optical time-domain reflectometry (BOTDR) is proposed. Firstly, we estimated the height through empirical formula calculation, theoretical analysis, and similar model simulation tests. Secondly, we studied the optimized layout of optical cables in the overburden in detail for predicting the maximum height of the WCFZ and keeping the cables in good performance during field prediction. Thirdly, we researched and optimized the borehole parameter... [more]