The mega debris flow that occurred on 13 August 2010 in Zoumaling Valley in Mianzhu County, China has done great damage to the local inhabitants, as well as to the re-construction projects in the quake-hit areas. Moreover, it is of high possibility that a secondary disaster would reappear and result in worse consequences. In order to maximize risk reduction of this problem, the local government planned to construct seven debris-resisting barriers across each ditch for mitigation of debris flow hazards in the future. In this paper, the numerical simulation fields of flow velocity, pressure, and mud depth of the Zoumaling debris flow had been computed by using finite volume method software based on computational fluid dynamics (CFD). The Bingham fluid was chosen as the constitutive model of this debris flow. The debris flow geometry model was a 3D model. The initial conditions, boundary conditions, control equations, and parameters were determined and adjusted by the actual conditions an... [more]

Indium tin oxide (ITO) transparent electrodes are troubled with high cost and poor mechanical stability. In this study, layer-by-layer (LBL)-processed thin films with single-walled carbon nanotubes (SWNTs) exhibited high transparency and electrical conductivity as a candidate for ITO replacement. The repetitive deposition of polycations and stabilized SWNTs with a negative surfactant exhibits sufficiently linear film growth and high optoelectronic performance to be used as transparent electrodes for vertically aligned (VA) liquid crystal display (LCD) cells. The LC molecules were uniformly aligned on the all of the prepared LBL electrodes. VA LCD cells with SWNT LBL electrodes exhibited voltage-transmittance (V-T) characteristics similar to those with the conventional ITO electrodes. Although the response speeds were slower than the LCD cell with the ITO electrode, as the SWNT layers increased, the display performance was closer to the LCD cells with conventional ITO electrode. This wo... [more]

The influence of pore fluid pressure on the normal deformation behaviors of joints is vital for understanding the interaction between hydraulic and mechanical processes of joints. The effect of pore fluid pressure on the normal deformation of a granite matched joint was investigated by laboratory experiments. Experimental results indicate pore fluid pressure significantly affects the normal deformation of jointed sample, and the relative normal deformation of jointed sample during fluid injection consists of the opening of the joint and the dilation of host rock. The action of pore fluid pressure on the joint follows the Terzaghi’s effective stress law. The normal deformation of the joint can be well quantitated by the generalized exponential model. The relative normal deformation of host rock during fluid injection would have a linear relationship with pore fluid pressure, and if affected by gas is more pronounced than water.

This paper introduces GEKKO as an optimization suite for Python. GEKKO specializes in dynamic optimization problems for mixed-integer, nonlinear, and differential algebraic equations (DAE) problems. By blending the approaches of typical algebraic modeling languages (AML) and optimal control packages, GEKKO greatly facilitates the development and application of tools such as nonlinear model predicative control (NMPC), real-time optimization (RTO), moving horizon estimation (MHE), and dynamic simulation. GEKKO is an object-oriented Python library that offers model construction, analysis tools, and visualization of simulation and optimization. In a single package, GEKKO provides model reduction, an object-oriented library for data reconciliation/model predictive control, and integrated problem construction/solution/visualization. This paper introduces the GEKKO Optimization Suite, presents GEKKO’s approach and unique place among AMLs and optimal control packages, and cites several example... [more]

Stevia rebaudiana Bertoni is a perennial shrub belonging to the Asteraceae family. The leaves contain a mixture of steviol glycosides with extraordinary sweetening properties, among which the most important are stevioside and rebaudioside A. These components have a high sweetening power, which is about 300 times that of sucrose, and a negligible calorie content. However, their extraction and purification are not easy. In this paper, the extraction technique under cyclic pressure, known as rapid solid-liquid dynamic extraction (RSLDE), was compared using a Naviglio extractor (NE) with conventional maceration. The aim was to identify an efficient and economically viable method for obtaining high amounts of steviol glycosides in a short time. Furthermore, a numerical model was set up for the solid-liquid extraction process of value-added compounds from natural sources. Several parameters must be evaluated in relation to the characteristics of the parts of the plant subjected to extraction... [more]

Knowledge of the bedding plane properties of coal seams is essential for the coalbed gas production because of their great influence on the inner flow characteristics and sorption features of gas and water. In this study, an experimental study on the anisotropic gas adsorption⁻desorption and permeability of coal is presented. The results show that during the adsorption⁻desorption process, an increase in the bedding plane angle of the specimen expands the length and area of the contact surface, thereby increasing the speed and quantity of adsorption and desorption. With an increase in the bedding angle, the number of pores and cracks was found to increase together with the volumetric strain. The evolution of permeability of coal heavily depended on stress⁻strain stages. The permeability decreased with the increase of stress at the initial compaction and elastic deformation stages, while it increased with the increase of stress at the stages of strain-hardening, softening and residual st... [more]

Normally, most of the accidents that occur in underground facilities are not instantaneous; rather, hazards build up gradually behind the scenes and are invisible due to the inherent structure of these facilities. An efficient inference system is highly desirable to monitor these facilities to avoid such accidents beforehand. A fuzzy inference system is a significant risk assessment method, but there are three critical challenges associated with fuzzy inference-based systems, i.e., rules determination, membership functions (MFs) distribution determination, and rules reduction to deal with the problem of dimensionality. In this paper, a simplified hierarchical fuzzy logic (SHFL) model has been suggested to assess underground risk while addressing the associated challenges. For rule determination, two new rule-designing and determination methods are introduced, namely average rules-based (ARB) and max rules-based (MRB). To determine efficient membership functions (MFs), a module named th... [more]

A mathematical model for the transmission dynamics of human immunodeficiency virus (HIV) within a host is developed. Our model focuses on the roles of immune response cells or cytotoxic lymphocytes (CTLs). The model includes active and inactive cytotoxic immune cells. The basic reproduction number and the global stability of the virus free equilibrium is carried out. The model is modified to include anti-retroviral treatment interventions and the controlled reproduction number is explored. Their effects on the HIV infection dynamics are investigated. Two different disease stage scenarios are assessed: early-stage and advanced-stage of the disease. Furthermore, optimal control theory is employed to enhance healthy CD4+ T cells, active cytotoxic immune cells and minimize the total cost of anti-retroviral treatment interventions. Two different anti-retroviral treatment interventions (RTI and PI) are incorporated. The results highlight the key roles of cytotoxic immune response in the HIV... [more]

Hot dry rock is developed by injecting cold water into high-temperature rock mass. At the same time, cold water is heated in contact with the rock mass. With the continuous influx of cold water, the surrounding rock will undergo a rapid cooling process, which results in several cycles of heating and cooling. However, there is little research on the influence of cycles of heating and cooling with circulating water on the mechanical properties of rock, which is of great importance to the stability of rock mass engineering in the process of energy development. In this paper, the effects of cyclic heating and cooling with circulating water on the damage of granite are studied using uniaxial compressive, Brazilian and acoustic emission (AE) tests. The results show that heat treatment temperature and number of cycles have important effects on the mechanical properties of granite as follows: (1) at the same treatment temperature, an increase in the number of cycles means that the distribution... [more]

Due to the complicated metabolism of mammalian cells, the corresponding dynamic mathematical models usually consist of large sets of differential and algebraic equations with a large number of parameters to be estimated. On the other hand, the measured data for estimating the model parameters are limited. Consequently, the parameter estimates may converge to a local minimum far from the optimal ones, especially when the initial guesses of the parameter values are poor. The methodology presented in this paper provides a systematic way for estimating parameters sequentially that generates better initial guesses for parameter estimation and improves the accuracy of the obtained metabolic model. The model parameters are first classified into four subsets of decreasing importance, based on the sensitivity of the model’s predictions on the parameters’ assumed values. The parameters in the most sensitive subset, typically a small fraction of the total, are estimated first. When estimating the... [more]

The microstructures of rock gradually evolve with changes in the external environment. This study focused on the microstructure evolution of glauberite and its weakening mechanism under different leaching conditions. The porosity were used as a characteristic index to study the effect of brine temperature and concentration on crack initiation and propagation in glauberite. The research subjects were specimens of ϕ3 × 10 mm cylindrical glauberite core, obtained from a bedded salt deposit buried more than 1000 m underground in the Yunying salt formation, China. The results showed that when the specimens were immersed in solution at low temperature, due to hydration impurities, cracks appeared spontaneously at the centre of the disc and the solution then penetrated the specimens via these cracks and dissolved the minerals around the crack lines. However, with an increase of temperature, the dissolution rate increased greatly, and crack nucleation and dissolved regions appeared simultaneou... [more]

A complete bibliometric analysis of the Scopus database was performed to identify the research trends related to lignin valorization from 2000 to 2016. The results from this analysis revealed an exponentially increasing number of publications and a high relevance of interdisciplinary collaboration. The simultaneous valorization of the three main components of lignocellulosic biomass (cellulose, hemicellulose, and lignin) has been revealed as a key aspect and optimal pretreatment is required for the subsequent lignin valorization. Research covers the determination of the lignin structure, isolation, and characterization; depolymerization by thermal and thermochemical methods; chemical, biochemical and biological conversion of depolymerized lignin; and lignin applications. Most methods for lignin depolymerization are focused on the selective cleavage of the β-O-4 linkage. Although many depolymerization methods have been developed, depolymerization with sodium hydroxide is the dominant pr... [more]

Systems composed of many components which interact with each other and lead to unpredictable global behaviour, are considered as complex systems. In a biological context, complex systems represent living systems composed of a large number of interacting elements. In order to study these systems, a precise mathematical modelling was typically used in this context. However, this modelling has limitations in the structural understanding and the behavioural study. In this sense, formal computational modelling is an approach that allows to model and to simulate dynamical properties of these particular systems. In this paper, we use Hybrid Functional Petri Net (HFPN), a Petri net extension dedicated to study and verify biopathways, to model and study the Methionine metabolic pathway. Methionine and its derivatives play significant roles in human bodies. We propose a set of simulations for the purpose of studying and analysing the Methionine pathway’s behaviour. Our simulation results have sh... [more]

Ion-sieves are a class of green adsorbent for extraction Li+ from salt lakes. Here, we propose a facile synthesis of hexagonal spinel LiMn₂O₄ (LMO) precursor under mild condition which was first prepared via a modified one-pot reduction hydrothermal method using KMnO₄ and ethanol. Subsequently, the stable spinel structured λ-MnO₂ (HMO) were prepared by acidification of LMO. The as-prepared HMO shows a unique hexagonal shape and can be used for rapid adsorption-desorption process for Li+adsorption. It was found that Li⁺ adsorption capacity of HMO was 24.7 mg·g^−1 in Li+ solution and the HMO also has a stable structure with manganese dissolution loss ratio of 3.9% during desorption process. Moreover, the lithium selectivity (α Li/Mg) reaches to 1.35 × 10³ in brine and the distribution coefficients (Kd) of Li+ is much greater than that of Mg2+. The results implied that HMO can be used in extract lithium from brine or seawater containing high ratio of magnesium and lithium.

Tight glutenites are typically composed of heterogeneous sandstone and gravel. Due to low or ultra-low permeability, it is difficult to achieve commercial production in tight glutenites without hydraulic fracturing. Efficient exploitation requires an in-depth understanding of the fracturing behavior of these reservoirs. This paper provides a numerical method that integrates the digital image processing (DIP) technique into a numerical code rock failure process analysis (RFPA). This method could consider the glutenite heterogeneities, including intrarock and interrock heterogeneities, and the practicability is verified through two numerical tests. Two-dimensional (2D) simulations show hydraulic fractures (HFs) can penetrate or deflect to propagate along the gravels, depending on the magnitude of stress anisotropy and gravel strength. Three-dimensional (3D) simulations with the consideration of gravel distribution orientation, gravel size and axial ratio show HFs could propagate past the... [more]

In this experiment, a variety of inorganic materials were simply compounded with Polysilicate Aluminum Ferric Sulfate (PSAFS) to treat emulsified oil-contaminated water. Manganese sulfate (MnSO₄), magnesium sulfate (MgSO₄), and zinc sulfate (ZnSO₄) were selected as the materials to modify PSAFS in order to obtain a coagulant with good flocculation performance. During the preparation of modified PSAFS, metal manganese, magnesium, and zinc were introduced for modification, and four factors were used to optimize the best proportion of modifiers and PSAFS. The results showed that the order of demulsification and oil-removal ability is as follows: Mn-PSAFS (Mn-modified PSAFS) > Zn-PSAFS (Zn-modified PSAFS) > Mg-PSAFS (Mg-modified PSAFS) > PSAFS. Modified PSAFS was characterized by infrared spectroscopy (IR) and a Scanning Electron Microscope (SEM). In the range of 604 cm−1 to 1200 cm−1, due to the complexation reaction between metal ions and polysilicic acid, the absorption peaks of the mod... [more]

The nonlinear flow regimes of a crossed fracture model consisting of two fractures have been investigated, in which the influences of hydraulic gradient, surface roughness, intersecting angle, and scale effect have been taken into account. However, in these attempts, the aperture of the two crossed fractures is the same and effects of aperture ratio have not been considered. This study aims to extend their works, characterizing nonlinear flow through a system of two intersecting fractures with different apertures. First, three experiment models with two fractures having different apertures were established and flow tests were carried out. Then, numerical simulations by solving the Navier-Stokes equations were performed and the results compared with the experiment results. Finally, the effects of fracture aperture on the critical pressure difference and the ratio of hydraulic aperture to mechanical aperture were systematically analyzed. The results show that the numerical simulation res... [more]

The Pseudo Steady-State (PSS) constant bDpss is defined as the difference between the dimensionless wellbore pressure and dimensionless average pressure of a reservoir with a PSS flow regime. As an important parameter, bDpss has been widely used for decline curve analysis with Type Curves. For a well with a finite-conductivity fracture, bDpss is independent of time and is a function of the penetration ratio of facture and fracture conductivity. In this study, we develop a new semi-analytical solution for bDpss calculations using the PSS function of a circular reservoir. Based on the semi-analytical solution, a new conductivity-influence function (CIF) representing the additional pressure drop caused by the effect of fracture conductivity is presented. A normalized conductivity-influence function (NCIF) is also developed to calculate the CIF. Finally, a new approximate solution is proposed to obtain the bDpss value. This approximate solution is a fast, accurate, and time-saving calculat... [more]

Internal erosion at soil⁻structure interfaces is a dangerous failure pattern in earth-fill water-retaining structures. However, existing studies concentrate on the investigations of internal erosion by assuming homogeneous materials, while ignoring the vulnerable soil⁻structure-interface internal erosion in realistic cases. Therefore, orthogonal and single-factor tests are carried out with a newly designed apparatus to investigate the critical hydraulic gradient of internal erosion on soil⁻structure interfaces. The main conclusions can be draw as follows: (1) the impact order of the three factors is: degree of compaction > roughness > clay content; (2) the critical hydraulic gradient increases as the degree of compaction and clay content increases. This effect is found to be more obvious in the higher range of the degree of soil compaction and clay content. However, there exists an optimum interface roughness making the antiseepage strength at the interface reach a maximum; (3) the evo... [more]

Synthetic ammonia produced from fossil fuels is essential for agriculture. However, the emissions-intensive nature of the Haber⁻Bosch process, as well as a depleting supply of these fossil fuels have motivated the production of ammonia using renewable sources of energy. Small-scale, distributed processes may better enable the use of renewables, but also result in a loss of economies of scale, so the high capital cost of the Haber⁻Bosch process may inhibit this paradigm shift. A process that operates at lower pressure and uses absorption rather than condensation to remove ammonia from unreacted nitrogen and hydrogen has been proposed as an alternative. In this work, a dynamic model of this absorbent-enhanced process is proposed and implemented in gPROMS ModelBuilder. This dynamic model is used to determine optimal designs of this process that minimize the 20-year net present cost at small scales of 100 kg/h to 10,000 kg/h when powered by wind energy. The capital cost of this process sca... [more]

Embedded devices are gaining popularity day by day due to the expanded use of Internet of Things applications. However, these embedded devices have limited capabilities concerning power and memory. Thus, the applications need to be tailored in such a way to perform the specified tasks within the constrained resources with the same accuracy. In Real-Time task scheduling, one of the challenging factors is the intelligent modelling of input tasks in such a way that it produces not only logically correct output within the deadline but also consumes minimum CPU power. Algorithms like Rate Monotonic and Earliest Deadline First compute hyper-period of input tasks for periodic repetition of the same set of tasks on CPU. However, at times when the tasks are not adequately modelled, they lead to an enormously high value of hyper-period which result in more CPU cycles and power consumption. Many state-of-the-art solutions are presented in this regard, but the main problem is that they limit tasks... [more]

The myogenic response is a key autoregulatory mechanism in the mammalian kidney. Triggered by blood pressure perturbations, it is well established that the myogenic response is initiated in the renal afferent arteriole and mediated by alterations in muscle tone and vascular diameter that counterbalance hemodynamic perturbations. The entire process involves several subcellular, cellular, and vascular mechanisms whose interactions remain poorly understood. Here, we model and investigate the myogenic response of a multicellular segment of an afferent arteriole. Extending existing work, we focus on providing an accurate—but still computationally tractable—representation of the coupling among the involved levels. For individual muscle cells, we include detailed Ca2+ signaling, transmembrane transport of ions, kinetics of myosin light chain phosphorylation, and contraction mechanics. Intercellular interactions are mediated by gap junctions between muscle or endothelial cells. Additional inte... [more]

A new direction of the 4th industrial revolution in manufacturing and IT industries is presented in this study, wherein the manufacturing sector will be able to survive in this period by achieving rapid and flexible change through effective convergence between both industries. Under such an environment, manufacturing IT requires speedy development and a new distribution form, as well as a new method of IT project development which is adequate for that form. Thus, this study compares and analyzes the waterfall method which is being used in general manufacturing System Integration (SI) projects and the proposed DevOps method, which requires faster distribution and improvement. This study confirms that the required human resources are less than the existing SI projects when system improvement is made using the DevOps method. At the same time, this method provides much-improved quality for the same price. Therefore, future manufacturing IT projects would achieve a faster and more efficient... [more]

The issue of “safe working„ has received increasing concern in recent years worldwide, especially in Europe. Several European countries developed specific strategies to ensure the safety of operators and the awareness on the potential risks that can emerge from a vast set of activities, including field activity in agriculture. Earlier investigations have lately investigated this topic, proposing quali-quantitative analysis applied to specific economic sectors. The present study focused on the working accidents occurred in agriculture over the last 6 years (2012⁻2017) in Italy. By exploring where and when injuries occurred, the socio-demographic profile of involved persons (including age, gender, nationality) and correlating these episodes to agricultural practices, the present paper reveals intrinsic patterns of safe (or unsafe) working conditions at a quite detailed spatial scale (administrative provinces) in Italy. Based on these results, training/educational programs should be plann... [more]

This work presents a mathematical model for the simultaneous optimisation of water and energy usage in hydraulic fracturing using a continuous time scheduling formulation. The recycling/reuse of fracturing water is achieved through the purification of flowback wastewater using thermally driven membrane distillation (MD). A detailed design model for this technology is incorporated within the water network superstructure in order to allow for the simultaneous optimisation of water, operation, capital cost, and energy used. The study also examines the feasibility of utilising the co-produced gas that is traditionally flared as a potential source of energy for MD. The application of the model results in a 22.42% reduction in freshwater consumption and 23.24% savings in the total cost of freshwater. The membrane thermal energy consumption is in the order of 244 × 10³ kJ/m³ of water, which is found to be less than the range of thermal consumption values reported for membrane distillation in... [more]