In this paper, a control method featuring double closed-loop compound robust is proposed to deal with the underperformances of double pump-double valve-controlled motors under external interference, such as poor stability of output speed, low controllability, and difficulties in managing synchronous output. By using this method, with the output speed of the hydraulic motor kept constant as the control objective, the sliding-mode controller of the single-channel motor is designed for the inner loop, while the double-channel cross-coupled enclosed-loop control is applied to the outer loop. Adjustments then are made to the speeds of the two motors, thus finally managing to realize the constant control on synchronous output of the two motors. Both simulation and test results indicate that this control method has produced higher control accuracy and robustness, with the system output speed difference lowered by 57.6%, the stability adjustment time shortened by 25% on average, and the synchr... [more]

The process of designing a longwall powered support is extremely complex and requires many operations related to the creation of a complete machine. The powered support section is one of the basic elements of the longwall system. It acts as protection for the working space and takes part in the process of excavating and transporting the spoil. The implementation of the support that meets the guidelines of the manufacturer and user requires an endurance analysis at the design stage conducted according to the regulations in force. The main objective of this research, pursued by the authors, was to perform the analysis of the ultimate strength of selected elements of the designed powered support section. The research was carried out with the use of special software that uses the finite element method. This article presents the analysis of the strength limits conducted with the help of the finite element method, determining the strength of selected elements of the longwall support section.... [more]

Vitrification has attracted much attention as an efficient method for solidifying heavy metals in hazardous solid wastes, but its effect is limited when hazardous solid wastes contain chlorides. Aiming at fly ash, a normal chlorine-containing solid waste, a novel process of chlorination melting and glass curing was developed to completely realize the harmlessness of heavy metals. Melting temperature, time, and auxiliary agent were adequate to realize the harmlessness, and their influence on the migration and transformation of Cl, Na, Pb, and Zn and the leaching of slag were studied. The results showed that the majority of Cl, Na, Pb, and Zn in the fly ash had been transferred to the soot, and the residual part in the slag had been solidified in glass by controlling the process conditions. Under the optimized conditions (12 wt.% CaO and 5 wt.% SiO2 was added, the N2 flow ratio was at 1 L/min, and the melting temperature was 1300 °C for 2 h), the leaching index was determined, including... [more]

Methanol, as a promising carbon-neutral fuel, has become a research hotspot worldwide. In this study, pure gasoline and gasoline blended with five different volume ratios of methanol (10%, 20%, 30%, 50%, and 75%) were selected as test fuels, which were referred to as M0, M10, M20, M30, M50, and M75. The experiments on carbon and pollutant emissions and performance were carried out on a passenger vehicle with gasoline direct injection (GDI) turbocharged engine using the steady-state, new European driving cycle (NEDC), and acceleration approaches. The results show that under steady-state conditions, as the methanol blending ratio increases, the volume of fuel consumption increases. Compared with pure gasoline, the equivalent fuel consumption and the CO2 emissions are reduced by 0.95 L/100 km (10.6%) and 18.95 g/km (9.6%) in maximum extent by fueling M75, respectively. In the NEDC, the CO2 emissions of M30 are reduced by 5.46 g/km (3.7%) compared with pure gasoline. After blending methano... [more]

A system identification of a two-wheeled robot (TWR) using a data-driven approach from its fundamental nonlinear kinematics is investigated. The fundamental model of the TWR is implemented in a Simulink environment and tested at various input/output operating conditions. The testing outcome of TWR’s fundamental dynamics generated 12 datasets. These datasets are used for system identification using simple autoregressive exogenous (ARX) and non-linear auto-regressive exogenous (NLARX) models. Initially the ARX structure is heuristically selected and estimated through a single operating condition. We conclude that the single ARX model does not satisfy TWR dynamics for all datasets in term of fitness. However, NLARX fitted the 12 estimated datasets and 2 validation datasets using sigmoid nonlinearity. The obtained results are compared with TWR’s fundamental dynamics and predicted outputs of the NLARX showed more than 98% accuracy at various operating conditions.

This paper exploits, through modeling and optimization, the experimental laboratory data on the biosorption of heavy metal ions Pb(II), Cd(II), and Zn(II) from aqueous media using soybean and soybean waste biomasses. The biosorption modeling was performed using the Response Surface Methodology, followed by optimization based on numerical methods. The aim of the modeling was to establish the most probable mathematical relationship between the dependent variables (the biosorption efficiency of the biosorbents when adsorbing metal ions, R(%), and the biosorption capacity of sorbents, q(mg/g)) and the process parameters (pH; sorbent dose, DS (g/L); initial metal ion concentration in solution, c0 (mg/L); contact time, tc (min); temperature, T (°C)), validated by methodologies specific to the multiple regression analysis. Afterward, sets of solutions were obtained through optimization that correlate various values of the process parameters to maximize the objective function. These solutions... [more]

In modern enterprises, all processes that are understood as structured activities intended for production, i [...]

An efficient and flexible production system can contribute to production solutions. These advantages of flexibility and efficiency are a benefit for small series productions or for individual articles. The aim of this research was to produce a genetic production system schedule similar to the sustainable production scheduling problem of a discrete product assembly plant, with more heterogeneous production lines, and controlled by one-time orders. First, we present a detailed mathematical model of the system under investigation. Then, we present the IT for a solution based on a soft calculation method. In connection with this model, a computer application was created that analyzed various versions of the model with several practical problems. The applicability of the method was analyzed with software specifically developed for this algorithm and was demonstrated on a practical example. The model handles the different products within an order, as well as their different versions. These w... [more]

The effect of ultrasound in combination of heat on the extraction yield and technological properties of chia seed mucilage was investigated. Chia seeds were mixed with distilled water at a seed-to-water ratio of 1:30. The dispersion was adjusted to pH 9 and treated either with heat extraction by water bath or with heat/ultrasound extraction by probe-type sonication at 50 °C and 80 °C for 30 and 60 min. The yield and technological properties of mucilage samples were evaluated. The heat/ultrasound extraction gave a greater yield of mucilage (6.92−10.52%) as compared to the heat extraction (1.03−1.86%). Images obtained from Scanning Electron Microscope (SEM) have shown that during heat/ultrasound extraction, the amount of mucilage fibers on the surface of chia seed decreased with the increased extraction time. Thus, the yield of mucilage prepared with heat/ultrasound extraction for 60 min was significantly higher than that of mucilage extracted for 30 min. However, the difference between... [more]

By-products from forestry, agriculture and nature areas are used in compost bedded-pack housing (CBP) systems for animals. In this communication, we discuss the application of a CBP system to animal farms and aspects related to the recycling and reuse of the materials in the context of a circular economy. This study is based on data from ongoing projects and literature. The following systems are discussed: (i) composting material applied to a specialized animal housing system; (ii) adding a horticultural component to the animal farm by reusing the compost, and (iii) a cooperative mixed cattle and crop farming system. The success of integrating a compost bedding component in the system depends largely on the skills of managing the composting process, the application of the material in the field, and the cost of acquiring the material. When materials are amply available, then a real contribution to the circular economy can be made. Cooperation between farmers in the utilization of by-pro... [more]

In this work, selections of seven international hop varieties and three craft beers obtained from them were analyzed by SPME-GC/MS techniques with the aim to describe their volatile chemical profile. The brewing process was also reported. Furthermore, the hop extracts and beers were investigated to determine their flavonoid and polyphenol content and to evaluate their antioxidant power by DPPH and ABTS assays. The findings showed the presence of compounds belonging to different chemical classes such as monoterpenes, sesquiterpenes, alcohols, esters and fatty acids. In particular, sesquiterpenes were the main compounds with β-caryophyllene (from 1.7 to 16.2%) and humulene (from 10.8 to 43.9%) as the major components in all varieties of dried hop cones investigated. On the contrary, with the exception for the Pacific sample, monoterpenes were the class of compounds that were more abundant in the hop extracts and, among these, β-myrcene appeared to be the predominant constituent (from 31.... [more]

As obtained geofluids from enhanced geothermal systems usually have lower temperatures and contain chemicals and impurities, a novel power cycle (NPC) with a unit capacity of several hundred kilowatts has been configured and developed in this study, with particular reference to the geofluid temperature (heat source) ranging from 110 °C to 170 °C. Using a suitable CO2-based mixture working fluid, a transcritical power cycle was developed. The novelty of the developed power cycle lies in the fact that an increasing-pressure endothermic process was realized in a few-hundred-meters-long downhole heat exchanger (DHE) by making use of gravitational potential energy, which increases the working fluid’s pressure and temperature at the turbine inlet and, hence, increases the cycle’s power output. The increasing-pressure endothermic process in the DHE has a better match with the temperature change of the heat source (geofluid), as does the exothermic process in the condenser with the temperature... [more]

Adeno-associated virus vectors (AAV) are reported to have a great potential for gene therapy, however, a major bottleneck for this kind of therapy is the limitation of production capacity. Higher specific AAV vector yield is often reported for adherent cell systems compared to cells in suspension, and a microcarrier-based culture is well established for the culture of anchored cells on a larger scale. The purpose of the present study was to explore how microcarrier cultures could provide a solution for the production of AAV vectors based on the triple plasmid transfection of HEK293T cells in a stirred tank bioreactor. In the present study, cells were grown and expanded in suspension, offering the ease of this type of operation, and were then anchored on microcarriers in order to proceed with transfection of the plasmids for transient AAV vector production. This process was developed in view of a bioreactor application in a 200 mL stirred-tank vessel where shear stress aspects were stud... [more]

The Zn-5%Al-rare earth alloy coating has been used in High-Vanadium Full-Locked Cable (HVFLC) that is made in China. This application has shown excellent protective performance. However, during practical use, the coating may appear to be deteriorated in various degrees, which may further worsen the corrosion resistance and mechanical properties of the cable. This paper focuses on High-Vanadium Full-Locked Cable (HVFLC). Firstly, different types of prefabricated defect treatments have been applied into the wires of the cable, followed by corrosion paste accelerated corrosion test and mechanical tensile properties test. The aim of this act is to figure out the effects on the corrosion resistance and mechanical properties of the wire due to different types of defects in alloy plating. The results show that the corrosion resistance of the wires has been greatly affected because of the solder joint defects. Furthermore, the tensile strength of the wire indicates a drop of about 40%. This re... [more]

Glutathione (GSH) is an anti-inflammatory and antioxidant biomolecule. Polycaprolactone (PCL) nanofiber mesh (NFM) is capable of the attachment and release of biomolecules for prolonged periods and has the potential as a transdermal drug delivery system during wound healing for a diabetic patient. Our earlier study found that high levels of sugar in diabetic male mice were significantly decreased by daily doses of glutathione administered on the mice. Furthermore, oxidative stress found in diabetic male mice led to the total depletion of glutathione levels in the body’s organs (pancreas, spleen, epididymis, and testis). The objective of this study was to attach GSH with PCL NFM for the controlled release of GSH biomolecules for long periods of time from the fiber mesh into a diabetic body. This study produced PCL NFM using an electrospun technique and tested it on mice to evaluate its efficiency as a dermal drug delivery mechanism. This study dissolved GSH (2.5 mg/mL) with phosphate-bu... [more]

The lack of accurate simulation model parameters in the optimization design process of variable fertilizer application devices has resulted in large errors between simulation and theoretical calculation results, which has restricted the development of variable fertilizer application devices to a certain extent. Additionally, there are few scholars studying urea granules, so many parameters of urea granular fertilizer cannot be directly obtained from the literature. The aim of this study is to calibrate a set of simulation parameters by combining physical and simulation tests. In this study, intrinsic parameters were systematically determined, including the particle size, particle density, elastic modulus, Poisson’s ratio and their static friction coefficients, rolling friction coefficients and restitution coefficients of urea particles. By performing the urea particle stacking test, the static friction coefficient between urea particles was calibrated to 0.27, and the rolling friction... [more]

Trastuzumab is a target-based recombinant humanized IgG1 monoclonal antibody (mAbs), extensively employed for treatment of metastatic breast cancer with human epidermal growth receptor 2 (HER2) overexpression. Studies around the world have reported that mAbs have substantial inter-patient unpredictable absorption, distribution, metabolism, and excretion (ADME-pharmacokinetics) because of multiple elements manipulating the concentration of mAbs in plasma. Herein, we have established a bioanalytical technique using UPLC-MS/MS with an easy sample workup method and in-solution digestion protocol to assay the trastuzumab plasma samples from breast cancer patients in clinical studies. Surrogated proteolytic peptides were used for accurate quantification of trastuzumab (CanMab) with a trastuzumab signature peptide with [13C6, 15N4]-arginine and [13C6, 15N2]-lysine stable isotope-labeled (SIL) peptide. Experiments to validate the method were accurately carried out according to the guidelines m... [more]

The aim of this study was to evaluate the effectiveness of microwave-assisted extraction (MAE) as an environmentally friendly approach compared to conventional heat-reflux extraction (CE) for the isolation of fennel (Foeniculum vulgare Mill.) seed polyphenols and to assess the bioactivity of the obtained extracts. Water, ethanol (30%, v/v) and acetone (30%, v/v) were used as extraction solvents, and the extraction was carried out varying the temperature (40, 60 and 80 °C), irradiation time (5 and 10 min) and microwave power (300 and 600 W). According to the total phenolic content (TPC), 30% acetone at 80 °C after 5 min of irradiation at 300 W proved to be the optimal MAE conditions for obtaining the highest yield of polyphenols. The phenolic profile of both extracts comprised 21 compounds, with cinnamic acids and flavonols being the most abundant. When compared to CE, the MAE extract showed a lower amount of TPC as well as the sum of all identified individual phenols, although both ext... [more]

Mammals and birds have quicker heart rates compared to other species. Mammalian cardiomyocytes have T-tubule membranes that facilitate rapid changes in Ca2+ concentrations. In contrast, bird cardiomyocytes do not possess T-tubule membranes, which raises the question of how birds achieve fast heartbeats. In this study, we compared the changes in Ca2+ concentration in cardiomyocytes isolated from adult quails and rats to elucidate the mechanism resulting in rapid heart rates in birds. Cardiomyocytes isolated from quails were significantly narrower than those isolated from rats. When Ca2+ concentration changes in the entire cardiomyocytes were measured using Fura-2 acetoxymethyl ester (AM), the time to peak was statistically longer in quails than in rats. In contrast, the decay time was markedly shorter in quails than in rats. As a result, the total time of Ca2+ concentration change was shorter in quails than in rats. A spatiotemporal analysis of Ca2+ concentration changes in quail cardio... [more]

An oxygen lance is the operation unit that generates supersonic oxygen jets, controls their behavior, and acts as a vital role in the steelmaking process. It is thought that airflow similar to a tornado may suppress upward splashing because of part of the jet pressure shifting from the axis of the oxygen lance to the tangential direction. Therefore, a new oxygen lance is designed to form a tornado jet, and the numerical simulation consequences are verified by the physical model. The structure of the new oxygen lance is optimized by numerical simulation results, and the comparison of simulation results before and after optimization is analyzed. On this basis, the effect of the cyclone oxygen lance on the upward splashing behavior, penetrating depth, turbulent kinetic energy, turbulent dissipation rate, and rotation of molten bath is investigated. The conclusions present that, compared with the conventional oxygen lance, the upward splashing with the cyclone oxygen lance decreases, and t... [more]

Catalytic processing of organochlorine wastes is considered an eco-friendly technology. Moreover, it allows us to obtain a value-added product—nanostructured carbon materials. However, the realization of this process is complicated by the aggressiveness of the reaction medium due to the presence of active chlorine species. The present research is focused on the characteristics of the carbon product obtained over the Ni-Pd catalyst containing 5 wt% of palladium in various quartz reactors: from a lab-scale reactor equipped with McBain balance to scaled-up reactors producing hundreds of grams. 1,2-dichloroethane was used as a model chlorine-substituted organic compound. The characterization of the materials was performed using scanning and transmission electron microscopies, Raman spectroscopy, and low-temperature nitrogen adsorption. Depending on the reactor type, the carbon yield varied from 14.0 to 24.2 g/g(cat). The resulting carbon nanofibers possess a segmented structure with disord... [more]

Electric vehicles (EVs) and hybrid electric vehicles (HEVs) are a new trend for the vehicle industry, due to the environmental regulations of the internal combustion engine (ICE) and pollutant emission of transportation. However, despite being very promising, the durability of the battery, due to overheating, is still an obstacle. In particular, electric vehicle batteries are manufactured with high voltage and high capacity to ensure power and energy efficiency. For this reason, a high temperature is generated in the system, which reduces the battery performance and life cycle. In this study, three different layouts, based on a direct contact air-cooled system, are designed to compare and improve the cooling performance. Further, a battery cooling test is conducted to verify the designed model. The results show that the spoiler model reduces the maximum battery temperature by (about) 16%, and effectively improves the temperature distribution of the battery cell by (about) 65%, when com... [more]

Background: The purpose of this study was to measure the preventive and regenerative effect of glutamine and probiotics induced by alcohol injury in Holtzman rats. Methods: Analytical, experimental and prospective study. The population consisted of 56 male rats between 300 and 350 g, distributed in three experimental phases: Pre-pilot phase PPP (6 rats), Pilot phase PP (10 rats), and Experimental phase EP (40 rats). In the pilot phase, 10 rats were subjected to damage with 8.5% ethanol, which was given intragastrically. The dosage was calculated for 10 rats in two groups: the first with 7.5 mL/kg in 5 rats and the second with 8.5 mL/kg in 5 rats. The experimental phase was performed in 40 rats divided into 6 groups, the negative control group (healthy), positive control group (injured), preventive experimental group (glutamine and glutamine with probiotic) and regenerative experimental group (glutamine and glutamine with probiotic). At the end of each phase, the rats were sacrificed wi... [more]

Black cumin oil adulteration has become a concern because it has numerous health benefits and a high price. Therefore, a simple, non-destructive, and rapid method to identify adulterations in black seed oil is necessary to protect the quality of the oils. This study aimed to perform a non-invasive method to authenticate black cumin oil by portable FT-NIR, FT-MIR, and Raman spectrometers. Spectra were collected with portable devices and analyzed using Soft Independent Modelling of Class Analogy (SIMCA) to generate a classification model to identify pure black cumin oil and partial least squares regression (PLSR) to predict the adulterant levels. For confirmation, the fatty acid profile of the oils was determined by gas chromatography (GC). SIMCA and PLSR models provided a very high performance in detecting adulterated samples in all portable units. These portable units showed great potential for rapid and non-destructive monitoring to identify adulterated black cumin oils.

In 2008, the Republic of Korea announced the Low Carbon Green Growth vision as the national growth engine. This Green Growth vision invested in developing state-of-the-art green technologies to minimize greenhouse gas and pollutant emissions. Following a change in administration, Korean green technologies were re-categorized into six core technologies for climate change response in 2014, and ten core technologies for carbon-neutrality in 2021. The government proposed the realization of an inclusive green state in the 3rd Five-Year Green Growth Plan announced in 2019. Following the Green New Deal announced in 2020, green technology policies and investments continue, with the declaration of 2050 carbon neutrality. In the past two years, government policies from the 2050 Carbon Neutrality Strategy to the 2050 Carbon-Neutral Scenario consider Carbon Capture Utilization and Storage (CCUS) as an important technology to reduce CO2 and meet carbon-neutral goals. This study examines major green... [more]