Vascular dementia (VD) is a cognitive impairment typical of advanced age with vascular etiology. It results from several vascular micro-accidents involving brain vessels carrying less oxygen and nutrients than it needs. This being a degenerative disease, the diagnosis often arrives too late, when the brain tissue is already damaged. Thus, prevention is the best solution to avoid irreversible cognitive impairment in patients with specific risk factors. Using the machine learning (ML) approach, our group evaluated Mini-Mental State Examination (MMSE) changes in patients affected by Alzheimer’s disease by considering different clinical parameters. We decided to apply a similar ML scheme to VD due to the consistent data obtained from the first work, including the assessment of various ML models (LASSO, RIDGE, Elastic Net, CART, Random Forest) for the outcome prediction (i.e., the MMSE modification throughout time). MMSE at recruitment, folate, MCV, PTH, creatinine, vitamin B12, TSH, and he... [more]

In this paper we consider a system of multiple mobile robots (MMRS) and the process of their concurrent motion in a shared two-dimensional workspace. The goal is to plan the robot movement along given fixed paths so as to minimize the completion time of all the robots while ensuring that they never collide. Thus, the considered problem combines the problems of robot schedule optimization with collision and deadlock avoidance. The problem formulation is presented and its equivalent reformulation that does not depend explicitly on the geometry of the robot paths is proposed. An event-based solution representation is proposed, allowing for a discrete optimization approach. Two types of possible deadlocks are identified and deadlock avoidance procedures are discussed. We proposed two types of solving methods. First, we implemented two metaheuristics: the local-search-based taboo search as well as the population-based artificial bee colony. Next, we implemented 14 simple constructive algori... [more]

Oil flow in inter-salt shale oil reservoirs is different from that of other oil fields due to its high salt content. Dissolution and diffusion occur when the salt minerals meet the water-based working fluid, resulting in drastic changes in the shale’s permeability. In addition, ignoring the stress-sensitive effect will cause significant errors in naturally fractured reservoirs for a large number of the natural fractures developed in shales. This study presents a transient pressure behavior model for a multi-stage fractured horizontal well (MFHW) in inter-salt shale oil reservoirs, considering the dissolution of salt and the stress sensitivity mentioned above. The analytical solution of our model was obtained by applying the methods of Pedrosa’s linearization, the perturbation technique and Laplace transformation. The transient pressure of a multi-stage fractured horizontal well in an inter-salt shale oil reservoir was obtained in real space by using the method of Stehfest’s numerical i... [more]

The performance of an externally pressurized gas journal bearing lubricated with R134a vapor used in an oil-free refrigeration centrifugal compressor is calculated by solving Reynold equations with the finite difference method (CFD). The load capacity, stiffness and mass flow rate of refrigerant vapor under conditions of various operational parameters are obtained and compared with that in air gas bearings. In addition, the influences of the average clearance, eccentricity ratios and supply vapor pressure on the static characteristics of journal bearings are investigated and discussed in detail. It concluded that the optimal operation parameters of gas journal bearings lubricated with R134a vapor are different with air journal bearings. These factors should be considered in the design process of R134a refrigerant vapor gas journal bearings.

The impact force and effective impact area of are water jet are two important indexes for evaluating jet performance, and the outlet shape of the nozzle has a great influence on jet performance. In this study, five nozzles with different outlet shapes were designed, and water jet test experiments were conducted at different inlet pressures using an independently built water jet impact test platform, and the influence law of nozzle shape on the center impact pressure and flow coefficient of the water jet was investigated. The influence of nozzle shape on the effective impact area and entrainment rate of water jet was further investigated by numerical simulation. The results showed that the center impact pressure of the circular nozzle was the greatest when the inlet pressure and the target distance were small. The center impact pressure, the flow coefficient, and the effective area of the triangular nozzle with sharp edges were better than the traditional circular nozzle when the inlet... [more]

In the process of in situ mining of underground oil shale, it is necessary to build an underground frozen wall around the mining area to prevent the inflow of groundwater and prevent oil and gas leakage. However, the water saturation of the frozen soil affects the formation of the freezing circle. In practical engineering, when building a frozen wall in soil under different water saturation conditions, the curtain is often not closed. It also affects the construction and operating costs of the entire project. In this paper, the methods of laboratory experiments and numerical simulation analysis are supplemented by the analysis of ordinary differential equations and partial differential equations. Aiming at the lowest cost, the temperature drop process and freezing time around the frozen well under different water saturation conditions are calculated and analyzed in detail. The formation law of the frozen wall curtain under different water saturation conditions is obtained. It provides... [more]

Separation of free fatty acids and triglycerides is important in the edible oil industry. In this study, both experimental and simulation approaches were conducted using falling film molecular distillation. A binary mixture of oleic acid as free fatty acid with refined soybean oil as triglyceride was used. Evaporation temperature range tested was from 110 to 160 °C, while other parameters such as condensation temperature, feeding rate, and vacuum pressure were fixed. The free fatty acid content of retentate was gradually decreased as evaporation temperature increased, while the free fatty acid content of distillate was approximately 100 wt.%, regardless of temperature. Triglycerides had an extremely low vapor pressure compared to oleic acid; therefore, their fraction in distillate was negligible. The mass conservation and transport equations were selected to explain the evaporation mechanism, and analytical solutions were simply introduced under the conditions of low mass fraction of v... [more]

Mass transfer is an omnipresent phenomenon in the chemical and related industries for which effective diffusivities (Di,eff) constitute a useful and simple mathematical tool, especially when dealing with multicomponent mixtures. Although several models have been published for Di,eff they generally involve simplifying assumptions that severely restrict their use. The current work presents the derivation of accurate analytical equations for Di,eff, which take into account the nonideal behavior of multicomponent mixtures. Additionally, it is demonstrated that for an ideal mixture the new model reduces to the well-known equations of Bird et al., which are the exact analytical solution for ideal systems. The procedure for Di,eff estimation is described in detail and exemplified with two chemical reactions: the liquid phase ethyl acetate synthesis and the high pressure gas phase methanol synthesis. Relative to the Bird et al. ideal equations the effective diffusivities calculated with the ne... [more]

In order to explore the mechanical response characteristics of fractured sandstone under true triaxial different medium principal stresses, matdem particle flow software was used to study the mechanical response characteristics, fracture mechanism and damage evolution characteristics of sandstone specimens under the conditions of 30 MPa, 40 MPa and 50 MPa respectively. The simulation results are verified by true triaxial test. The results show that under true triaxial stress, the increase of medium principal stress is beneficial to increase the strength of sandstone. The fracture degree of the specimen increases with the increase of the intermediate principal stress, and finally the interlacing macroscopic cracks are formed. When the intermediate principal stress is perpendicular to the fracture strike, the fracture mode of sandstone is that the macroscopic fracture plane is perpendicular to the fracture strike, and the fracture mechanism of sandstone under true triaxial compression is... [more]

Gasification is a promising and attractive thermochemical method for biomass-to-energy conversion, with fluidized bed reactors being one of the best options for large-scale operations. Olive residues in particular are potentially excellent candidate biomass fuels in the Mediterranean area, due to the region’s increased capacity in olive oil production. Herein, the gasification experiments of olive kernels in a 2 MWth air-blown, bubbling fluidized bed reactor located at CENER’s facilities (BIO2C) in Navarra, Spain are presented. Even though technical issues were demonstrated due to the operation of the plant with a high-density biomass fuel and given the scale of the process, a quasi-steady-state and isothermal 12 h operation at an equivalence ratio of 0.25 ± 0.03 was attained. Given the satisfactory experimental results, an Aspen Plus simulation model of the process was also attempted. Notably, the proposed methodology agrees well with the experimental results and can be regarded as a... [more]

Scaling in a hydrothermal type of geothermal well reduces or interrupts the production of geothermal energy. Calcite is one of the most common scales in geothermal wells. The reason for its formation in geothermal production wells is clear. The flowing up of geothermal water causes a change in the pressure and temperature, which results in the escape of CO2 gas from the geothermal water, causing a rise in pH and the supersaturation of CaCO3 in the solution. To predict scaling in a new geothermal well, conditional data for geothermal well simulations are required. It is important to determine what field data are needed and how to obtain them. It is necessary to deal with some parameters that are hard to measure and that have not been described in detail in the existing literature. In this study, a two-phase flow model and a chemical reaction equilibrium model are integrated to simulate the scaling process in production wells. Based on the simulation, a comprehensive and practical approa... [more]

This study was initiated in view of the phenomenon that hydrostatic turntable rails are prone to scrape damage when the liquid hydrostatic turntable is running under fixed partial load. The existing bias-load hydrostatic turntable oil film bearing characteristics are mainly calculated by using the calculus integration method and CFD fluid simulation method. The calculating formula obtained by the calculus integration method is complex and inefficient. The CFD fluid simulation calculation method requires 3D modeling and meshing of the oil film, which is a tedious and time-consuming process and may not yield convergent calculation results due to improper meshing methods or boundary condition settings. In order to solve the shortage of the above calculation methods, this paper simplifies and equates the uneven thickness of the oil film of each sealing edge of the oil pad of the bias-loaded hydrostatic rotary table to the equivalent uniform thickness of the oil film, and based on this idea... [more]

Despite intensive research over the last three decades, it has not yet been possible to bring an effective vaccine against human immunodeficiency virus (HIV) and the resulting acquired immunodeficiency syndrome (AIDS) to market. Virus-like particles (VLP) are a promising approach for efficient and effective vaccination and could play an important role in the fight against HIV. For example, HEK293 (human embryo kidney) cells can be used to produce virus-like particles. In this context, given the quality-by-design (QbD) concept for manufacturing, a digital twin is of great importance for the production of HIV-Gag-formed VLPs. In this work, a dynamic metabolic model for the production of HIV-Gag VLPs was developed and validated. The model can represent the VLP production as well as the consumption or formation of all important substrates and metabolites. Thus, in combination with already described process analytical technology (PAT) methods, the final step towards the implementation of a... [more]

The pre-swirl inflow generated by guide vanes could improve the hydrodynamic performances of centrifugal pumps as long as the inflow matches the patterns of internal flow of the impeller. In this work, we present a numerical investigation on the internal flow in a centrifugal impeller subjected to inflow artificially constructed with simple pre-swirling; unsteady Reynolds-Averaged Navier-Stokes (URANS) simulations are performed at the designed flow rate with five values of rotating velocity of the inflow, i.e., Urot/Uref = −0.5, −0.3, 0.0, 0.3 and 0.5, where Urot and Uref denote the rotating and normal velocity component at the entrance of the inflow tube, respectively. The primary objective of this work is to reveal the three-dimensional characteristics of internal flow of the impeller as influenced by the superimposed pre-swirl inflow, and to identify the propagation of inflow within the impeller. The numerical data are presented and analyzed in terms of the streamline fields, the di... [more]

The sedimentation characteristics of quartz particles affect their separation and settling dehydration processes. Particle morphology determines the sedimentation equilibrium velocity. In this paper, the sedimentation of a single quartz particle is characterized by employing experimental and CFD-DEM approaches. SEM served to examine quartz particles measuring 30−500 μm, and they exhibited flaky−blocky morphologies with an average long−middle axis ratio of 1.6. Consistent with the SEM-detected morphological features of the quartz particles, suggested here is a simpler drag coefficient model, followed by verification of the model with experimental data. The results show that the velocity of a quartz particle in the non-settling direction had a fluctuation of ±0.2 mm/s. The fluctuation reached 0.4 mm/s at varying settlement release angles. The order in which the particles reached sedimentation equilibrium velocity during the settlement process was double-cone, single-cone, and square when... [more]

The “Song of Life (SOL)” is a kind of music therapy in palliative care for addressing emotional and existential needs in terminally ill patients nearing the end of life. Few previous studies focus on objective data analysis methods to validate the effectiveness of psychotherapy therapy for patients’ overall state. This article combines the entropy weighting method (EWM) and the technique for order preference by similarity to the ideal solution (TOPSIS) method to evaluate the effectiveness of SOL music therapy and the treatment satisfaction of the patients and family members. Firstly, the collaborative filtering algorithm (CFA) machine learning algorithm is used to predict the missing ratings a patient might have given to a variable. Secondly, the EWM determines the weights of quality of life, spiritual well-being, ego-integrity, overall quality of life, and momentary distress. Thirdly, the EWM method is applied for the TOPSIS evaluation model to evaluate the patient’s state pre- and po... [more]

The method of plugging while drilling has been one of the commonly used methods to control formation loss during drilling. The damage to materials for plugging while drilling to MWD has become a complex problem. For many years, field engineers had insufficient knowledge of the passing performance of materials for plugging while drilling in measurement while drilling (MWD). In the existing research, the blocking mechanism of materials for plugging while drilling to mud screen during the flow process is still unclear. In this study, we use computational fluid dynamics coupled with discrete element method (CFD−DEM) to investigate materials’ plugging mechanism while drilling. The results show that the migration process of lost circulation materials (LCMs) in the mud screen can be divided into three stages, displacement, retention, and accumulation of LCMs. The blocking mechanism of LCMs on the mud screen comes from two aspects. One is from the bridging of LCMs with larger particle size in... [more]

Consistency in gas flow behavior under various operating conditions is expected for uniform cutting performance in the thermal cutting process. The slope of the cut front in the kerf slot of a sample cutting material varies with the operating condition which affects the gas flow pattern. Therefore, how the nozzle exit diameter and the slope of the cut front effects gas flow behavior has been studied using the Reynolds averaged Navier−Stokes (RANS) based k−ω turbulence model. Convergent−straight-type nozzles with exit diameters φexit of 1.5 mm, 2 mm and 2.5 mm were used to study the flow patterns through the kerf slots of variable cut front slopes. The numerical simulation results were then compared with the results obtained from the Schlieren experiments. In addition, image processing was performed in the Schlieren images for clear visualization and precise comparison of the numerical and experimental data. The results confirm that a nozzle with an exit diameter of 2 mm shows a higher... [more]

Biochemical engineering deals with the processing of biological or chemical materials using enzymes or living cells as biological catalysts [...]

Computational fluid dynamics (CFD) have been extensively used to simulate the hydrodynamics of multiphase flows (MPFs) in rotating machinery. In the presence of a granular dense phase, the Kinetic Theory of Granular Flow (KTGF) is usually coupled to Eulerian multi-fluid models to obtain tractable computational fluid models. In the present work, the hydrodynamic behavior of a three dimensional, industrial scale, and rotating drum granulator with gas−solid flows is assessed using the Eulerian−Eulerian approach coupled with the k-ε standard turbulence model. A Eulerian−Eulerian Two-Fluid Model (TFM) is used with the KTGF model for the granular phase. The sensitivities to different operating parameters, including the rotational speed (8, 16, and 24 rpm), inclination degree (3.57∘, 5.57∘, and 7.57∘), and degree of filling (20%, 30%, and 40%) are studied. Moreover, the impact of the drag model on the simulation accuracy is investigated. The flow behavior, regime transitions, and particle dis... [more]

This paper studies the characteristics of four dual-load systems, coaxial different sides, coaxial same side, different axis same side, and coplanar coaxial, based on the principle of near-field resonance wireless power transmission. Firstly, a dual-load cooperative coupling equivalent circuit model is established, the mathematical expression of system energy efficiency is derived, and the influence of the cross-coupling of the receiving coils in the system on the performance of the system is compared and analyzed in four coupling situations. Secondly, the magnetic field distribution characteristics and the influence of transmission distance and load impedance on the transmission characteristics are studied by electromagnetic field simulation software. Finally, the experimental results show that the maximum efficiency of the dual-load wireless power transmission system is only 0.43 in the case of coaxial and coplanar coupling, which is not suitable for power transmission. In the case o... [more]

Due to the large size and large span of heavy-duty machine tools, the structural deformation errors caused by gravity account for a large proportion of the static errors, and the influence of gravity deformation must thus be considered in the machine tool precision design. This paper proposes a precision design method for heavy-duty vertical machining centers based on gravity deformation error modelling. By abstracting the machine tool into a multibody system topology, the static error model of the machine tool is established based on the multibody system theory and a homogeneous coordinate transformation. Assuming that the static error of each motion axis is composed of two parts, i.e., the manufacturing-induced geometric error and the gravity deformation error, the machine tool stiffness model of the relationship between gravity and deformation error is developed using the spatial beam elements. In the modelling process, the stiffness coefficients and volume coefficients of the compo... [more]

Large eddy simulations were performed for the conjugate heat transfer in a ribbed channel with a geometry, that mimics the internal cooling passage of a gas turbine, using 566, 100, 10, and 1 as the solid and fluid thermal conductivity ratios (K*) and 30,000, 7000 (turbulent flow), and 1000 (laminar flow) as the Reynolds numbers. A fully coupled simulation was conducted using the immersed boundary method (IBM) and a dynamic sub-grid-scale (SGS) model. In pure convection, a decrease in the Reynolds number from 30,000 to 7000 increased the heat transfer on the channel wall by 5% but decreased that on the rib by 20%. When K* > 10, the Reynolds number effect is stronger in the rib than in the wall. In the laminar flow, the effect of conduction appears at a low K*, and the heat transfer promotion is poor in the typical ribbed channel geometry. In the turbulent flow, if K* ≥ 100, then a heat transfer promotion is expected in the ribbed channel even at a low Reynolds number. For K* < 10, t... [more]

This research study investigates the modelling and simulation of biomass anaerobic dark fermentation in bio-hydrogen production in a continuous plug flow reactor. A CFD multiphase full transient model in long-term horizons was adopted to model dark fermentation biohydrogen production in continuous mode. Both the continuous discharge of biomass, which prevents the accumulation of solid parts, and the recirculation of the liquid phase ensure constant access to the nutrient solution. The effect of the hydraulic retention time (HRT), pH and the feed rate on the bio-hydrogen yield and production rates were examined in the simulation stage. Metabolite proportions (VFA: acetic, propionic, butyric) constitute important parameters influencing the bio-hydrogen production efficiency. The model of substrate inhibition on bio-hydrogen production from glucose by attached cells of the microorganism T. neapolitana applied to the modelling of the kinetics of bio-hydrogen production was used. The modell... [more]

Al-Sn-Al wafer bonding is a new semiconductor manufacturing technology that plays an important role in device manufacturing. Optimization of the bonding process and testing of the bonding strength remain key issues. However, using only physical experiments to study the above problems presents difficulties such as repeating many experiments, high costs, and low efficiency. Deep learning algorithms can quickly simulate complex physical correlations by training large amounts of data, which is a good solution to the difficulties in studying wafer bonding. Therefore, this paper proposes the use of deep learning models (2-layer CNN and 50-layer ResNet) to achieve autonomous recognition of bonding strengths corresponding to different bonding conditions, and the results from a comparative test set show that the ResNet model has an accuracy of 99.17%, outperforming the CNN model with an accuracy of 91.67%. Then, the identified images are analyzed using the Canny edge detector, which showed that... [more]