A foreign metal object will deteriorate the performance of wireless power transfer (WPT) systems and cause insecurity issues. Therefore, the influence principles and rules of foreign metal objects on soft-switching conditions of Class-E inverters and the performance of WPT systems are developed in this paper. The effects of different metal materials on coil parameters at different frequencies and positions are analyzed first, then the effects of foreign metal objects on soft-switching conditions of Class-E inverters and the power transfer capability of WPT systems are investigated. Principle analyses and simulation results demonstrate that there are significantly different effects on the soft-switching conditions and power transfer when a foreign metal object is placed near the transmitter coil or the receiver coil. In addition, the monotonicity of the variation in power transfer also depends on the position of the foreign metal object. Finally, a WPT experimental prototype with a Clas... [more]

CO₂ (GWP = 1) is considered as a promising natural alternative refrigerant to HFC-134a in mobile air conditioning (MAC) applications. The objective of this study is to investigate the cooling performance characteristics of a CO₂ MAC system. A prototype CO₂ MAC system, consisting of a CO₂ electrical compressor, CO₂ parallel flow microchannel heat exchangers, and an electrical expansion valve, was developed and tested. Factor analysis experiments were conducted to reveal the effect of outdoor temperature on the cooling performance of this CO₂ MAC system. Compared with a conventional R134a MAC system, the prototype CO₂ MAC system achieved comparable cooling capacity, but had COP reductions of 26% and 10% at 27 °C and 45 °C outdoor conditions, respectively. In addition, based on refrigerant properties, theoretical cycle analysis was done to reveal the impact of evaporator, gas cooler and compressor, on the system cooling performance. It is concluded that the increase of overall compressor... [more]

When electric vehicles (EVs) run on the wireless power supply coils, the multi-load working mode will appear, showing that that more than one EV is collecting energy from one coil. Aiming at the stability problem of multi-load mode, this paper mainly analyzes how the number of loads influences the system stability and defines the boundary condition of the load quantity. Meanwhile, an L-shaped coil structure and the T-shaped magnetic core structure are proposed to solve the problem of coil breakdown for high-power supply situations. The proposed structures effectively reduce the supply coils’ self-inductance on the premise of guaranteeing the power transfer, and ensure the security of the multi-load system. At last, the validity of theoretical analysis is verified by simulations and experiments.

The use of a computer simulator, previously developed and validated, applied to a four-stroke marine dual-fuel engine, has allowed the authors to present in this paper a solution to improve the overall efficiency of the engine by adopting a hybrid turbocharger. This component replaces the original one allowing, in addition to maintaining the previous usual functions, the production of electricity to satisfy part of the ship’s electric load. In this study the application of the hybrid turbocharger concerns an engine powered by natural gas in particular. The turbocharger substitution involves a significant variation of the engine load governor operating mode. The improved engine characteristics that the hybrid turbocharger facilitates, compared to the original, are highlighted by the results reported in tabular and graphical form, for different engine loads and speeds.

Dissolved gas analysis (DGA) is widely used to detect the incipient fault of power transformers. However, the accuracy is greatly limited by selection of DGA features and performance of fault diagnostic model. This paper proposed a fault diagnostic method integrating feature selection and diagnostic model optimization. Firstly, this paper set up three feature sets with eight basic DGA gases, 28 DGA gas ratios and 36 hybrid DGA features, respectively. Then, to eliminate the interference of weak-relevant and irrelevant features, the genetic-algorithm-SVM-feature-screen (GA-SVM-FS) model was built to screen out the optimal hybrid DGA features subset (OHFS) from three feature sets. Next, using the OHFS as the input, the support vector machine (SVM) multi-classifier optimized by ISGOSVM (SVM classifier optimized by improved social group optimization) was built to diagnose fault types of transformers. Finally, the performance of OHFS and ISGOSVM diagnostic model was tested and compared with... [more]

The failure mechanism of heterogeneous rocks (geological materials), especially under hydraulic conditions, is important in geological engineering. The coupled mechanism of flow-stress-damage should be determined for the stability of rock mass engineering under triaxial stress states. Based on poroelasticity and damage theory, a three-dimensional coupled model of the flow-stress-damage failure process is studied, focusing mainly on the coupled characteristics of permeability evolution and damage in nonhomogeneous rocks. The influences of numerous mesoscale mechanical and hydraulic properties, including homogeneity, residual strength coefficient, loading rates, and strength criteria, on the macro mechanical response are analyzed. Results reveal that the stress sensitive factor and damage coefficient are key variables for controlling the progress of permeability evolution, and these can reflect the hydraulic properties under pre-peak and post-peak separately. Moreover, several experiment... [more]

Liver resection is an important clinical intervention to treat liver disease. Following liver resection, patients exhibit a wide range of outcomes including normal recovery, suppressed recovery, or liver failure, depending on the regenerative capacity of the remnant liver. The objective of this work is to study the distinct patient outcomes post hepatectomy and determine the processes that are accountable for liver failure. Our model based approach shows that cell death is one of the important processes but not the sole controlling process responsible for liver failure. Additionally, our simulations showed wide variation in the timescale of liver failure that is consistent with the clinically observed timescales of post hepatectomy liver failure scenarios. Liver failure can take place either instantaneously or after a certain delay. We analyzed a virtual patient cohort and concluded that remnant liver fraction is a key regulator of the timescale of liver failure, with higher remnant li... [more]

Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein metabolism in the context of a single hepatocyte. The integrated model includes a description of low density lipoprotein (LDL) receptor and cholesterol synthesis, delipidation of very low density lipoproteins (VLDLs) to LDLs and subsequent lipoprotein endocytosis. Model analysis shows that cholesterol biosynthesis produces the majority of intracellular cholesterol. The availability of free receptors does not greatly effect the concentration of intracellular cholesterol, but has a detrimental effect on extracellular VLDL and LDL levels. We test our model by considering its ability to reproduce the known biology of Familial Hypercholesterolaemia and statin therapy. In each case the model reproduces the known biological behaviour. Quantitative diff... [more]

A recommender system is currently applied in many different domains, seeking to provide users with recommendation services according to their personalized preferences to relieve rising online information congestion. As the number of mobile phone users is large and growing, mobile tourist guides have attracted considerable research interest in recent years. In this paper, we propose an optimal travel route recommender system by analyzing the data history of previous users. The open dataset used covers the travel data from thousands of mobile tourists who visited Jeju in a full year. Our approach is not only personalized to users’ preferences but also able to recommend a travel route rather than individual POIs (Points of Interest). An association rule mining-based approach, which takes into account contextual information (date, season and places already visited by previous users), is used to produce travel routes from the large dataset. Furthermore, to ensure the reasonability of the re... [more]

Cell-free protein expression has emerged as an important approach in systems and synthetic biology, and a promising technology for personalized point of care medicine. Cell-free systems derived from crude whole cell extracts have shown remarkable utility as a protein synthesis technology. However, if cell-free platforms for on-demand biomanufacturing are to become a reality, the performance limits of these systems must be defined and optimized. Toward this goal, we modeled E. coli cell-free protein expression using a sequence specific dynamic constraint-based approach in which metabolite measurements were directly incorporated into the flux estimation problem. A cell-free metabolic network was constructed by removing growth associated reactions from the iAF1260 reconstruction of K-12 MG1655 E. coli. Sequence specific descriptions of transcription and translation processes were then added to this metabolic network to describe protein production. A linear programming problem was then sol... [more]

Subsection split grouting technology can effectively improve the grouting efficiency and homogeneity of grouting in a target reinforcement area. It is therefore necessary to clarify the reinforcement mechanism and characteristics of the soft filling medium under the condition of split grouting. A three-dimensional grouting simulation test of segmented split grouting in a soft filling medium was conducted. The distribution characteristics and thicknesses of the grouting veins were obtained under the condition of segmented grouting. The mechanical mechanism of segmented split grouting reinforcement, based on the distribution characteristics of different grouting veins, was revealed. After grouting, a uniaxial compression test and an indoor permeation test were conducted. Based on the method of the region-weighted average, the corresponding permeability coefficient and the elastic modulus of each splitting-compaction region were obtained. The quantitative relationship between the mechanic... [more]

The Colebrook equation is implicitly given in respect to the unknown flow friction factor λ; λ = ζ ( R e , ε * , λ ) which cannot be expressed explicitly in exact way without simplifications and use of approximate calculus. A common approach to solve it is through the Newton⁻Raphson iterative procedure or through the fixed-point iterative procedure. Both require in some cases, up to seven iterations. On the other hand, numerous more powerful iterative methods such as three- or two-point methods, etc. are available. The purpose is to choose optimal iterative method in order to solve the implicit Colebrook equation for flow friction accurately using the least possible number of iterations. The methods are thoroughly tested and those which require the least possible number of iterations to reach the accurate solution are identified. The most powerful three-point methods require, in the worst case, only two iterations to reach the final solution. The recommended representativ... [more]

Spray-drying is an increasingly popular technology for the production of amorphous solid dispersions (ASDs) in the pharmaceutical industry that is used in the early evaluation and industrial production of formulations. Efficient screening of ASD in the earliest phase of drug development is therefore critical. A novel miniaturized atomization equipment for screening spray-dried solid dispersions (SDSDs) in early formulation and process development was developed. An in-depth comparison between the equipment/process parameters and performance of our novel screening device and a laboratory Büchi B290 mini spray-dryer was performed. Equipment qualification was conducted by comparing the particle/powder attributes, i.e., miscibility/solid state, residual solvent, and morphological properties of binary SDSDs of itraconazole prepared at both screening and laboratory scales. The operating mode of the miniaturized device was able to reproduce similar process conditions/parameters (e.g., outlet t... [more]

The biological slow filtration (BSF) system as a simple and efficient environmental technology has been widely applied in treatment of ‘micro-polluted’ water. At present, many related studies have focused on the removal efficiency of biological indicators (such as bacteria and viruses). However, there is less research on the removal performance of nutrients and organics in the BSF system. In this paper, we employed a lab-scale biological slow filter to study the removal efficiency and degradation mechanism of nutrients and organics. We proved through adsorption of filter layer at the early running stage and biodegradation at the later stage, the BSF system could achieve effective removal of NH₃-N, TN, TP, CODMn and turbidity and the corresponding removal rates are 83.65%, 42.45%, 42.94%, 60.41% and 83.55%, respectively. Furthermore, we also explored the influence of four main factors (filtration rate, filter depth, hydraulic head and temperature) and their interactions on removal rates... [more]

Modeling the coupled evolution of strain and CH₄ seepage under conventional triaxial compression is the key to understanding enhanced permeability in coal. An abrupt transition of gas-stress coupled behavior at the dilatancy boundary is studied by the strain-based percolation model. Based on orthogonal experiments of triaxial stress with CH₄ seepage, a complete stress-strain relationship and the corresponding evolution of volumetric strain and permeability are obtained. At the dilatant boundary of volumetric strain, modeling of stress-dependent permeability is ineffective when considering the effective deviatoric stress influenced by confining pressure and pore pressure. The computed tomography (CT) analysis shows that coal can be a continuous medium of pore-based structure before the dilatant boundary, but a discontinuous medium of fracture-based structure. The multiscale pore structure geometry dominates the mechanical behavior transition and the sudden change in CH₄ seepage. By the... [more]

The goal-oriented control policies of cybernetic models have been used to predict metabolic phenomena such as the behavior of gene knockout strains, complex substrate uptake patterns, and dynamic metabolic flux distributions. Cybernetic theory builds on the principle that metabolic regulation is driven towards attaining goals that correspond to an organism’s survival or displaying a specific phenotype in response to a stimulus. Here, we have modeled the prostaglandin (PG) metabolism in mouse bone marrow derived macrophage (BMDM) cells stimulated by Kdo2-Lipid A (KLA) and adenosine triphosphate (ATP), using cybernetic control variables. Prostaglandins are a well characterized set of inflammatory lipids derived from arachidonic acid. The transcriptomic and lipidomic data for prostaglandin biosynthesis and conversion were obtained from the LIPID MAPS database. The model parameters were estimated using a two-step hybrid optimization approach. A genetic algorithm was used to determine the p... [more]

Using conventional coagulant, low turbidity water is difficult to achieve standard. This research uses aluminum chloride, titanium tetrachloride, and sodium silicate as raw materials for the preparation of polyaluminum titanium silicate chloride (PATC). PATC is used to treat low turbidity. The synthetic PATC showed the best coagulating effect in treated water under the following experimental conditions: Reaction temperature of 50 °C, and n(Ti)/n(Al), n(-OH)/n(Ti+Al), and n(Si)/n(Ti+Al) were 0.3, 0.2, and 1.0, respectively. The species distribution and the transformation of PATC showed that the interaction between titanium tetrachloride, sodium silicate, and the hydrolysate of Al influenced the morphology distribution of Al. Temperature and -OH greatly affected the distribution of Alb in PATC. The analysis of infrared spectra and X-ray diffraction indicated that both titanium tetrachloride and sodium silicate had complex chemical reactions with aluminum chloride. Si-O-Ti and Si-O-Al pro... [more]

In this report we have discussed the important role of molecular modeling, especially the use of the molecular dynamics method, in investigating transport processes in nanoporous materials such as membranes. With the availability of high performance computers, molecular modeling can now be used to study rather complex systems at a fraction of the cost or time requirements of experimental studies. Molecular modeling techniques have the advantage of being able to access spatial and temporal resolution which are difficult to reach in experimental studies. For example, sub-Angstrom level spatial resolution is very accessible as is sub-femtosecond temporal resolution. Due to these advantages, simulation can play two important roles: Firstly because of the increased spatial and temporal resolution, it can help understand phenomena not well understood. As an example, we discuss the study of reverse osmosis processes. Before simulations were used it was thought the separation of water from sal... [more]

Landfill is still the most important process to dispose of municipal solid waste in China, while landfill closure aims for pollution control, security control, and better land reuse. However, uneven settlement of landfill cover system is very likely to cause deformation and cracking. The objective of this paper is to examine the effects of geogrid reinforcement on the deformation behaviour and hydraulic conductivity of the bentonite-sand mixtures that are subjected to differential settlement. The laboratory model tests were performed on bentonite-sand mixtures with and without the inclusion of geogrid reinforcement. By maintaining the type and location of the geogrid within the liner systems as constant, the thickness of the bentonite-sand mixtures is varied. The performation of the liner systems with and without the inclusion of geogrid reinforcement was assessed by using jack to control differential settlement. Un-reinforced bentonite-sand mixtures of 100 mm and 200 mm thickness were... [more]

The ineffective control of the release of pollutants into water has led to serious water pollution. Compared with conditions in the past, the polluting components in aquatic environments have become increasingly complex. Some emerging substances have led to a new threat to the safety of water. Therefore, developing cost-effective technologies for the remediation of water pollution is urgently needed. Adsorption has been considered the most effective operational unit in water treatment processes and thus adsorption materials have gained wide attention. Among them, metal organic frameworks (denoted as MOFs) have been rapidly developed in recent years due to their unique physicochemical performance. They are characterized by larger porosity and larger specific surface area, easier pore structure designing, and comfortable structural modification. In many fields such as adsorption, separation, storage, and transportation, MOFs show a better performance than conventional adsorption material... [more]

Fluidized bed reactors have been increasingly applied for mass production of Carbon Nanotube (CNT) using catalytic chemical vapor deposition technology. Effect of particle size (dp = 131 μm and 220 μm) on fluidization characteristics and aggregation behavior of the CNT particles have been determined in a fluidized bed for its design and scale-up. The CNT aggregation properties such as size and shape were measured in the dilute phase of a fluidized bed (0.15 m-ID × 2.6 m high) by the laser sheet technique for the visualization. Two CNT particle beds showed different tendency in variations of the aggregates factors with gas velocity due to differences in factors contributing to the aggregate formation. The CNT particles with a larger mean size presented as relatively larger in the aggregate size than the smaller CNT particles at given gas velocities. The aggregates from the large CNT particles showed a sharp increase in the aspect ratio and rapid decrease in the roundness and the solidit... [more]

A coupled thermal-nonlinear hydraulic-mechanical (THM) model for fault water inrush was carried out in this paper to study the water-rock-temperature interactions and predict the fault water inrush. First, the governing equations of the coupled THM model were established by coupling the particle transport equation, nonlinear flow equation, mechanical equation, and the heat transfer equation. Second, by setting different boundary conditions, the mechanical model, nonlinear hydraulic-mechanical (HM) coupling model, and the thermal-nonlinear hydraulic-mechanical (THM) coupling model were established, respectively. Finally, a numerical simulation of these models was established by using COMSOL Multiphysics. Results indicate that the nonlinear water flow equation could describe the nonlinear water flow process in the fractured zone of the fault. The mining stress and the water velocity had a great influence on the temperature of the fault zone. The temperature change of the fault zone can r... [more]

Microdroplet dosing to cell on a chip could meet the demand of narrow diffusion distance, controllable pulse dosing and less impact to cells. In this work, we studied the diffusion process of microdroplet cell pulse dosing in the three-layer sandwich structure of PDMS (polydimethylsiloxane)/PCTE (polycarbonate) microporous membrane/PDMS chip. The mathematical model is established to solve the diffusion process and the process of rhodamine transfer to micro-traps is simulated. The rhodamine mass fraction distribution, pressure field and velocity field around the microdroplet and cell surfaces are analyzed for further study of interdiffusion and convective diffusion effect. The cell pulse dosing time and drug delivery efficiency could be controlled by adjusting microdroplet and culture solution velocity without impairing cells at micro-traps. Furthermore, the accuracy and controllability of the cell dosing pulse time and maximum drug mass fraction on cell surfaces are achieved and the dr... [more]

Predictive functional control (PFC) is a fast and effective controller that is widely used for processes with simple dynamics. This paper proposes some techniques for improving its reliability when applied to systems with more challenging dynamics, such as those with open-loop unstable poles, oscillatory modes, or integrating modes. One historical proposal considered is to eliminate or cancel the undesirable poles via input shaping of the predictions, but this approach is shown to sometimes result in relatively poor performance. Consequently, this paper proposes to shape these poles, rather than cancelling them, to further enhance the tuning, feasibility, and stability properties of PFC. The proposed modification is analysed and evaluated on several numerical examples and also a hardware application.

Developing new stirred gas⁻liquid⁻solid reactors with high mass transfer capabilities is still a challenge. In this publication, we present a new concept of multiphase reactor using a stationary catalytic foam and a gas-inducing impeller. The gas⁻liquid (GL) and liquid⁻solid (LS) mass transfer rates in this reactor were compared to a stirred reactor with basket filled with beads. Batch absorption of hydrogen and measurement of α-methylstyrene hydrogenation rate on Pd/Al2O3 catalyst were used to evaluate kGLaGL coefficients and kLS coefficients, respectively. With similar LS transfer rates to the basket-reactor and much higher GL transfer rates, the new reactor reveals a very promising tool for intrinsic kinetics investigations.