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Showing records 36978 to 37002 of 43292. [First] Page: 1 1477 1478 1479 1480 1481 1482 1483 1484 1485 Last
36978. LAPSE:2023.2153
A Feature Engineering-Assisted CM Technology for SMPS Output Aluminium Electrolytic Capacitors (AEC) Considering D-ESR-Q-Z Parameters
February 21, 2023 (v1)
Subject: Process Control
Keywords: aluminum electrolytic capacitor, condition monitoring, fault diagnosis, feature engineering, LCR meter, switched mode power supply
Recent research has seen an interest in the condition monitoring (CM) approach for aluminium electrolytic capacitors (AEC), which are present in switched-mode power supplies and other power electronics equipment. From various literature reviews conducted and from a failure mode effect analysis (FMEA) standpoint, the most critical and prone to fault component with the highest percentage is mostly capacitors. Due to its long-lasting ability (endurance), CM offers a better paradigm for AEC due to its application. However, owing to severe conditions (over-voltage, mechanical stress, high temperature) that could occur during use, they (capacitors) could be exposed to early breakdown and overall shutdown of the SMPS. This study considered accelerated life testing (electrical stress and long-term frequency testing) for the component due to its endurance in thousands of hours. We have set up the experiment test bench to monitor the critical electrical parameters: dissipation factor (D), equiva... [more]
36979. LAPSE:2023.2152
Fabrication of Multiscale 1-Octadecene Monolayer Patterned Arrays Based on a Chemomechanical Method
February 21, 2023 (v1)
Subject: Process Control
Keywords: 1-octadecene, chemomechanical method, self-assembly, silicon
A controlled and self-assembled micromachining system was built to fabricate a mico/nanoscale monolayer patterned array on a silicon surface using a diamond tip. The process was as follows: (1) we preprocessed a silicon wafer to obtain a hydrogen-terminated silicon surface; (2) we scratched three rectangular arrays of 10 μm × 3 μm with a spacing of 2 μm on the silicon surface with a diamond tip in 1-octadecene solution; the Si-H bonds were broken, and silicon free radicals were formed; (3) the 1-octadecene molecules were connected with silicon atoms based on Si-C covalent bonds, and the 1-octadecene nano monolayer was self-assembled on the patterned arrays of the silicon surface. Atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and Sessile water contact angles were used to detect and characterize the self-assembled monolayers (SAMs). The XPS results showed that the Si2p peak and the O1s peak were significantly decreased after self-assembly; however, the C1s peak w... [more]
36980. LAPSE:2023.2151
Microstructure Evolution of Inertia Friction Welded Joints of TC21 Titanium Alloy
February 21, 2023 (v1)
Subject: Materials
Keywords: inertia friction welding, microstructure, phase composition, TC21 titanium alloy
In this paper, TC21 titanium alloy welded joints were successfully formed through inertial friction welding (IFW) processes. Microstructure evolution of IFW joints was investigated by way of different analysis methods including optical microscope (OM), scanning electron microscope(SEM), Electron Back-Scattered Diffraction(EBSD), X-Ray Diffraction(XRD), and Energy Dispersive Spectrometer(EDS). The results indicate that large-sized equiaxial β grains, original α phases, and basketweave structure existing in the BM have completely disappeared in the WZ. Instead, fine equiaxial grains sized at 20−30 μm and very fine α + β lamellar microstructure are formed in the WZ. However, as transition zones, the microstructures of the TMAZ and HAZ are also in transition state while the microstructures existing in the BM partially remain in the TMAZ and completely remain in the HAZ. In addition, second α phases are precipitated and fine α + β lamellar microstructure are formed on the original β base in... [more]
36981. LAPSE:2023.2150
The Effects of Payment for Environmental Services on Environmental Improvement and Poverty Reduction: A Meta-Regression Analysis
February 21, 2023 (v1)
Subject: Environment
Keywords: environmental improvement, meta-regression analysis, payment for environmental services, poverty reduction
Based on the empirical literature of the payments for environmental services (PES) projects for the environmental improvement and poverty reduction, this paper uses a meta-regression analysis method to study whether PES can achieve the effects of improving environmental quality and reducing poverty levels. For the meta-regression analysis, the literature was mainly searched by the Web of Science core journal database. The explanatory variables of meta-regression analysis are the hypothesis and related features of the models in the original literature by generally taking the binary dummy variables or categorical variables. The dependent variables used in this paper are environmental improvement and poverty reduction. The results show that PES projects based on private ownership rights are more conducive to poverty reduction and environmental improvement. If the country is a buyer of a PES project, it is more likely to achieve the effects of environmental enhancement and poverty alleviat... [more]
36982. LAPSE:2023.2149
Sustainable Machining: Tool Life Criterion Based on Work Surface Quality
February 21, 2023 (v1)
Subject: Environment
Keywords: cubic boron nitride, cutting speed, economic sustainability, feed rate, process cost, sustainable machining, tool wear, tungsten carbide
Extending the use of a component without compromising its intended functionality is the neatest approach to enhance sustainability. From this perspective, limiting the working life of a cutting tool based merely on the blunting of its cutting edge to a specific value is highly questionable. The very question that serves as the motivation for this work is, “why should tool life criterion be based on the shape of the tool when all that matters for business is the quality of the part being machined?”. This work puts forward a tool life criterion based on the surface quality of the machined part. The proof of the concept is provided by a series of face-turning experiments performed on a commonly used alloy steel using the following cutting inserts in dry conditions: (1) uncoated carbide; (2) coated carbide; and (3) cubic boron nitride (CBN). It is found that different combinations of tooling and cutting parameters lead to entirely different values of surface roughness at the same level of... [more]
36983. LAPSE:2023.2148
Antibacterial and Antifungal Activity of Functionalized Cotton Fabric with Nanocomposite Based on Silver Nanoparticles and Carboxymethyl Chitosan
February 21, 2023 (v1)
Subject: Materials
Keywords: antifungal, antimicrobial, cotton, functionalized fabric, nanocomposite
Cotton is the most widely used natural fiber for textiles; however, the capacity of cotton fibers to absorb large amounts of moisture, retain oxygen, and have a high specific surface area makes them more prone to microbial contamination, becoming an appropriate medium for the growth of bacteria and fungi. In recent years, the incorporation of silver nanoparticles in textile products has been widely used due to their broad-spectrum antibacterial activity and low toxicity towards mammalian cells. The aim of the current study is to continue the assessment of our developed nanocomposite and evaluate the antibacterial and antifungal activity of the nanocomposite based on silver nanoparticles and carboxymethyl chitosan (AgNPs-CMC) against Escherichia coli, Staphylococcus aureus, and Candida albicans, evaluated by the well diffusion method. The antibacterial activity against E. coli and S. aureus was also evaluated by the qualitative method of inhibition zone and the quantitative method of co... [more]
36984. LAPSE:2023.2147
Optimization of the Oxidative Coupling of Methane Process for Ethylene Production
February 21, 2023 (v1)
Subject: Energy Systems
Keywords: Ethylene, heat integration, Natural Gas, OCM process, process simulation
The oxidative coupling of methane (OCM) process is considered an intriguing route for the production of ethylene, one of the most demanded petrochemical products on the market. Ethylene can be produced by various methods, but the most widely used is the steam cracking process. However, due to the current instability of the crude oil market and the shale gas revolution, the production of olefins from natural gas has opened a new path for companies to mitigate the high demand for crude oil while utilizing an abundant amount of natural gas. In this work, the OCM process was compared with other existing processes, and the process was simulated using Aspen HYSYS. The flowsheet was divided into four sections, namely (i) the reaction section, (ii) the water removal section, (iii) the carbon dioxide capture section, and (iv) the ethylene purification section. Each section was thoroughly discussed, and the heat integration of the process was performed to ensure maximum energy utilization. The h... [more]
36985. LAPSE:2023.2146
Analysis of Sealing Performance of Metal B-ring Self-Tightening Structure
February 21, 2023 (v1)
Subject: Materials
Keywords: B-ring, FEM, leakage, self-tightening seal
Process industries often use B-ring self-tightening sealing structures and rely on interference assembly to meet the initial sealing requirements. Therefore, determining reasonable B-ring material, size and interference is crucial to ensure the sealing performance of the structure. In this paper, based on elastic deformation analysis, the deformation co-ordination equation of a B-ring sealing structure was established, and a sealing contact pressure calculation formula was obtained, with discussion of the main factors affecting sealing performance. With the finite element method, transient temperature field analysis was carried out for startup and shutdown load cases, and contact analysis was carried out for interference assembly, startup and shutdown. Based on the evaluation criteria of sealing performance with proposed sealing rate and leakage parameters, the effects of material properties, interference, B-ring size, etc., on sealing performance were investigated, revealing that alth... [more]
36986. LAPSE:2023.2145
Digital Twin-Driven Approach for Process Management and Traceability towards Ship Industry
February 21, 2023 (v1)
Subject: Modelling and Simulations
Keywords: BNN, digital twin, DT-driven prediction, process management, ship industry
The digital twin (DT) approach has risen in popularity for applications in many industrial process managements. By applying the “Shipyard 4.0” digital transformation trend, the ship industry is developing techniques able to reduce risks by improving operation process management. This study proposes a combination of a DT approach and practical experiment as part of a five-tier framework for DT-driven process management in the ship industry. This study focuses on the characteristic scenarios and crucial parameters within the ship engine system and shipping cargo container in operation procedures. DT-based models and platforms are established in this study based on the basic modeling of Maya and scene rendering of Unity 3D. To address the fusion issue of multi-source heterogeneous data in the ship operation process, a Bayesian neural network (BNN) method is introduced into DT’s virtual model layer and data support layer. By integrating an improved BNN-based algorithm into DT-based models,... [more]
36987. LAPSE:2023.2144
Box-Behnken Design (BBD) Application for Optimization of Chromatographic Conditions in RP-HPLC Method Development for the Estimation of Thymoquinone in Nigella sativa Seed Powder
February 21, 2023 (v1)
Subject: Process Design
Keywords: BBD, HPLC, Nigella sativa, thymoquinone, validation
Thymoquinone (THY) is a bioactive compound present in the seed powder of Nigella sativa (NS). This research aims to precisely and accurately estimate THY using high-performance liquid chromatography (HPLC) with a Quality by Design (QbD) application. Box-Behnken design (BBD) was employed to optimize the chromatographic conditions for HPLC method development, taking mobile phase flow rate, pH of the buffer, and λmax as independent variables and retention time and tailing factor as the measured responses. The mobile phase composition was methanol: acetonitrile: buffer (2.2 mM ammonium formate) at the ratio of 35:50:15 v/v/v on a Symmetry® C18 (5 μm, 3.9 × 150 mm) column. In isocratic mode, it had a flow rate 0.9 mL min−1 and eluted analyte was detected at 249 nm. Validation parameters followed the International Council for Harmonization (ICH) guidelines for the new HPLC method. The method was linear over the range 6.25−100 µg mL−1 with a coefficient of determination (r2) of 0.9957. The li... [more]
36988. LAPSE:2023.2143
Detection and Isolation of Incipiently Developing Fault Using Wasserstein Distance
February 21, 2023 (v1)
Subject: Numerical Methods and Statistics
Keywords: incipient fault detection and isolation, multivariate statistical analysis, Riemannian block coordinate descent, Wasserstein distance
This paper develops an incipient fault detection and isolation method using the Wasserstein distance, which measures the difference between the probability distributions of normal and faulty data sets from the aspect of optimal transport. For fault detection, a moving window based approach is introduced, resulting in two monitoring statistics that are constructed based on the Wasserstein distance. From analysis of the limiting distribution under multivariate Gaussian case, it is proved that the difference measured by the Wasserstein distance is more sensitive than conventional quadratic statistics like Hotelling’s T2 and Squared Prediction Error (SPE). For non-Gaussian distributed data, a project robust Wasserstein distance (PRW) model is proposed and the Riemannian block coordinate descent (RBCD) algorithm is applied to estimate the Wasserstein distance, which is fast when the number of sampled data is large. In addition, a fault isolation method is further proposed once the incipient... [more]
36989. LAPSE:2023.2142
Practical Application-Oriented Energy Management for a Plug-In Hybrid Electric Bus Using a Dynamic SOC Design Zone Plan Method
February 21, 2023 (v1)
Subject: Process Design
Keywords: dynamic SOC design zone, energy management, hardware in loop simulation, plug-in hybrid electric bus, Q-learning
The main problem in current energy management is the ability of practical application. To address the problem, this paper proposes a reinforcement learning (RL)-based energy management by combining Tubule Q-learning and Pontryagin’s Minimum Principle (PMP) algorithms for a plug-in hybrid electric bus (PHEB). The main innovation distinguished from the existing energy management strategies is that a dynamic SOC design zone plan method is proposed. It is characterized by two aspects: ① a series of fixed locations are defined in the city bus route and a linear SOC reference trajectory is re-planned at fixed locations; ② a triangle zone will be re-planned based on the linear SOC reference trajectory. Additionally, a one-dimensional state space is also designed to ensure the real-time control. The off-line trainings demonstrate that the agent of the RL-based energy management can be well trained and has good generalization performance. The results of hardware in loop simulation (HIL) demonst... [more]
36990. LAPSE:2023.2141
Efficient Removal of Dyes from Aqueous Solution by Adsorption on L-Arginine-Modified Mesoporous Silica Nanoparticles
February 21, 2023 (v1)
Subject: Materials
Keywords: dye removal, mesoporous silica, surface modification
The use of mesoporous silica modified with L-arginine (Ar-MSNPs) for the removal of ionic dyes from aqueous solutions has been investigated. Several analytical techniques have been used to determine the characteristics of nanoadsorbents. The removal of crystal violet and fluorescein was performed using the batch method to investigate the effects of cultivation pH, initial concentrations of dyes, and exposure time on adsorption efficiency. The optimum adsorption of fluorescein was achieved at pH 2, whereas the optimum adsorption of crystal violet was achieved at pH 13. The equilibrium was established in both systems at 20 min at low concentrations, and approximately 30 min at high concentrations. The equilibrium adsorption data was analyzed using Langmuir and Freundlich isotherm models. The correlation coefficient (R2) values of the isotherms presented the best fit with the Langmuir isotherm. The adsorption kinetic data was fitted with the pseudo second-order model for both systems.
36991. LAPSE:2023.2140
Performance Optimization on 3D Diffuser of Volute Pump Using Kriging Model
February 21, 2023 (v1)
Subject: Modelling and Simulations
Keywords: 3D diffuser, Computational Fluid Dynamics, Kriging, Optimization, Surrogate Model, volute pump
In order to enhance the hydraulic performance of the volute pump, the Kriging model and genetic algorithm (GA) were used to optimize the 3D diffuser of the volute pump, and the hydraulic performance of the optimized model was compared and analyzed with the original model. The volute pump diffuser model was parameterized by BladeGen software. A total of 14 parameters such as the distance between the leading and trailing edges and the central axis, and the inlet and outlet vane angle were selected as design variables, and the efficiency under the design condition was taken as the optimization objective. A total of 70 sets of sample data were randomly selected in the design space to train and test the Kriging model. The optimal solution was obtained by GA. The shape and inner flow of the optimized diffuser were compared with those of the original diffuser. The research results showed that the Kriging model can effectively establish the high-precision mathematical function between the desi... [more]
36992. LAPSE:2023.2139
Selective Ion Removal by Capacitive Deionization (CDI)-Based Technologies
February 21, 2023 (v1)
Subject: Materials
Keywords: capacitive deionization, desalination, electrode materials, heavy metal, nutrients, selective ion removal, water softening
Severe freshwater shortages and global pollution make selective removal of target ions from solutions of great significance for water purification and resource recovery. Capacitive deionization (CDI) removes charged ions and molecules from water by applying a low applied electric field across the electrodes and has received much attention due to its lower energy consumption and sustainability. Its application field has been expanding in the past few years. In this paper, we report an overview of the current status of selective ion removal in CDI. This paper also discusses the prospects of selective CDI, including desalination, water softening, heavy metal removal and recovery, nutrient removal, and other common ion removal techniques. The insights from this review will inform the implementation of CDI technology.
36993. LAPSE:2023.2138
Optimization of Variable Stiffness Joint in Robot Manipulator Using a Novel NSWOA-MARCOS Approach
February 21, 2023 (v1)
Subject: Process Design
Keywords: design, design parameters, Modelling, Optimization, robots
Robots and robotic systems have become an inevitable part of modern industrial settings. Robotics systems are being introduced for various household services as well. As the interactions between the workspace of robots and humans increases, there is an increased likelihood of unintended harm being caused by the robots to humans due to collisions or abrupt contact. To mitigate this, active and passive compliant mechanisms must be introduced in these systems. In this study, a design optimization case study is carried out for the optimization of a passive compliance mechanism achieved with variable stiffness joints realized by the use of permanent magnets. Three design parameters of the systems, namely, inner stator width, outer stator width, and magnet height, are considered. The objective is to minimize the weight and maximize the maximum torque. A nature-inspired metaheuristic hybridized with a multi-criteria decision-making method is introduced to achieve this. The Non-dominated Sorti... [more]
36994. LAPSE:2023.2137
Effect of Wettability on Vacuum-Driven Bubble Nucleation
February 21, 2023 (v1)
Subject: Process Control
Keywords: bubble nucleation, hydrophilic, hydrophobic, surface roughness, vacuum boiling, wettability
Nucleation is the formation of a new phase that has the ability to irreversibly and spontaneously grow into a large-sized nucleus within the body of a metastable parent phase. In this experimental work, the effect of wettability on the incipiation of vacuum-driven bubble nucleation, boiling, and the consequent rate of evaporative cooling are studied. One hydrophilic (untreated), and three hydrophobic (chlorinated polydimethylsiloxane, chlorinated fluoroalkylmethylsiloxane and (heptadecafluoro-1,1,2,2-tetrahydrodecyl)triethoxysilane) glass vials of different wettabilities were filled with degassed deionized water and exposed to a controlled vacuum inside a transparent desiccator. The vacuum was increased by 34 mbar abs. (1 inHg rel.) steps with 15-min waiting period to observe bubble nucleation. The average onset pressures for gas/vapor bubble nucleation in CM, CF, and HT vials were 911 ± 30, 911 ± 34, and 925 ± 17 mbar abs., respectively. Bubble nucleation was not observed in hydrophil... [more]
36995. LAPSE:2023.2136
Evaluation of Weighted Mean of Vectors Algorithm for Identification of Solar Cell Parameters
February 21, 2023 (v1)
Subject: System Identification
Keywords: double-diode model, Optimization, parameter identification, photovoltaic, single-diode model, triple-diode model
The environmental and technical benefits of renewable energy sources make expanding their use essential in our lives. The main source of renewable energy used in this work is photovoltaic energy. Photovoltaic cells are a clean energy source dependent on solar irradiance to generate electricity from sunlight. The identification of solar cell variables is one of the main items in the simulation and modeling of photovoltaic models. The models used in this work are triple-diode, double-diode, and single-diode solar cells. A novel optimization method called weighted mean of vectors (INFO) is applied for estimating the solar cell variables in the three models. The fitness function of identification is to minimize the root-mean-square error (RMSE) between the measured data of current and the data of simulated current based on the parameters identified from the algorithms. The INFO technique is compared with another seven methods: Harris hawk optimization (HHO), tunicate swarm algorithm (TSA),... [more]
36996. LAPSE:2023.2135
Bottom-Up Estimates of the Cost of Supplying High-Temperature Industrial Process Heat from Intermittent Renewable Electricity and Thermal Energy Storage in Australia
February 21, 2023 (v1)
Subject: Energy Systems
Keywords: alumina calcination, economic analysis, electric battery storage, electrification, high-temperature, industrial process heat, levelized cost of energy, Renewable and Sustainable Energy, thermal storage
We report the upper and lower bounds for the levelized cost of high-temperature industrial process heat, supplied from electricity generated with solar-photovoltaic (PV) and wind turbines in combination with either thermal or electric battery storage using hourly typical meteorological year (TMY) data, in systems sized to supply between 80% and 100% of continuous thermal demand at a site in the northern part of Western Australia. The system is chosen to supply high-temperature air as the heat transfer media at temperatures of 1000 °C, which is a typical temperature for an alumina or a lime calcination plant. A simplified model of the electrical energy plant has been developed using performance characteristics of real PV and wind systems and TMY data of renewable energy resources. This was used to simulate a large sample of possible system configurations and find the optimal combination of the renewable resources and storage systems, sized to provide renewable shares (RES) of between 80... [more]
36997. LAPSE:2023.2134
Optimization of the Subcritical Butane Extraction of Tung Oil and Its Mechanism Analysis
February 21, 2023 (v1)
Subject: Optimization
Keywords: Extraction, response surface method, subcritical, tung oil
Tung oil is an important dry grease. In order to overcome the deficiencies of traditional processes in oil production, the preparation of tung oil was carried out by the butane-subcritical method. A response surface optimization experiment was carried out based on Design-Expert software, and the best process parameters were obtained. The extraction temperature was 42.98 °C, the extraction time was 43.77 min, the particle size of the raw material was 38.88 mesh, and the oil yield of tung oil under this condition reached 67.437%. The fatty acid composition of tung oil was analyzed by Gas Chromatography-Mass Spectrometry (GC-MS): the content of α-oleostearic acid was 74.99%, linoleic acid content was 8.83%, oleic acid content was 7.42%, palmitic acid content was 2.02%, and stearic acid content was 4.35%. Through the analysis of the oil sample obtained, five indicators showed that the process of obtaining oil products met the requirements of the national standard. By simulating the subcrit... [more]
36998. LAPSE:2023.2133
Residence Time Distribution of Non-Spherical Particles in a Continuous Rotary Drum
February 21, 2023 (v1)
Subject: Other
Keywords: Biomass, mean residence time, non-spherical particles, residence time distribution, rotary drum
The motion of non-spherical particles with sharp edges, as they are commonly involved in practice, was characterized by residence time distribution (RTD) measurement in a continuous drum. Particles with two sizes, 6 and 10 mm, and two densities, 750 and 2085 kg/m3, were used in the experiments. The effects of rotation speed (3−11 rpm), incline angle (2−4°), feed rate, and mixture composition were investigated and compared to the results of other researchers on particles without sharp edges. We also fitted the RTD with an axial dispersion model to obtain a better insight into the flow behavior. MRT of non-spherical particles with sharp edges depends on ω−α similar to other shapes, while the value of alpha is higher for particles with sharp edges (0.9 < α < 1.24), especially at high incline angles. The MRT depends on incline angle, β−b, where b varies between 0.81 (at low ω) and 1.34 (at high ω), while it is close to 1 for other shapes. Feed rate has a slight effect on the MRT of p... [more]
36999. LAPSE:2023.2132
Experimental Studies of Nonlinear Dynamics of Asynchronous Electric Drives with Variable Load
February 21, 2023 (v1)
Subject: Process Control
Keywords: frequency control, induction motor, nonlinear dynamical systems, sensorless control, traction drive
This article presents the results of the analysis of experimental data that were obtained during industrial tests of an adjustable asynchronous traction electric drive of a shuttle car for the mining industry. During these tests, by changing the parameters of the stator voltage, the stator currents of the induction motor were optimized when the load changes over a wide range (from −1.5 Tn to + 1.5 Tn). The authors managed to significantly reduce the effective values of the stator currents of the motor, but at the same time it was found that, with the load and even the rate of its change, oscillations of the effective values of currents with variable amplitude and frequency occur. It turned out to be very difficult to explain these oscillations and the variability of their parameters using traditional mathematical methods for describing processes in asynchronous electric motors. Vector equations and diagrams are valid only at constant frequencies of the stator voltage and, in the modes... [more]
37000. LAPSE:2023.2131
Design of a Combined Magnetic and Gas Dynamic Bearing for High-Speed Micro-Gas Turbine Power Plants with an Axial Gap Brushless Generator
February 21, 2023 (v1)
Subject: Energy Systems
Keywords: axial generator, distributed generation, gas turbine installation, gas-dynamic bearing, high-strength steel, magnetic bearing, radial generator, tensile strength, yield strength
The development of modern energy is moving towards distributed generation, in which numerous sources of different capacities are connected into a single network. This makes it possible to increase the reliability of the entire system, since the probability of the failure of several energy sources at the same time is small. One of the major possibilities of distributed generation is the generation of electric energy based on high-speed gas turbines. The main advantage of these sources are high specific energy indicators, which improve with increasing rotation speed. However, it is technically difficult to realize the advantages of high-speed devices. It is necessary to abandon the step-down gearbox for the generator and directly connect it to a high-speed turbine, use high-strength materials that can withstand the load from centrifugal forces, abandon traditional plain bearings, and use special supports. Installations with generators that have a radial rotor design are the most widespre... [more]
37001. LAPSE:2023.2130
Cytochrome P450 3A2 and PGP-MDR1-Mediated Pharmacokinetic Interaction of Sinapic Acid with Ibrutinib in Rats: Potential Food/Herb−Drug Interaction
February 21, 2023 (v1)
Subject: Food & Agricultural Processes
Keywords: drug interaction, ibrutinib, pharmacodynamics, pharmacokinetics, sinapic acid
Ibrutinib (IBR) metabolism (primarily by CYP3A enzyme) is the main route of excretion for IBR, which could lead to drug−drug/herb−drug interactions with herbal medicines, nutritional supplements, and other foods. Sinapic acid (SA) is a bioactive phytonutrient that is used as a dietary supplement to treat a variety of illnesses. Pharmacokinetic interactions may occur when IBR interacts with SA, which influences the pharmacokinetic processes such as absorption, distribution, metabolism, and excretion. Therefore, it is obligatory to investigate the safety apprehensions of such parallel usage and to evaluate the possible impact of SA on the pharmacokinetics of IBR and propose a possible interaction mechanism in an animal model. The IBR concentration in plasma samples was determined using a validated UHPLC-MS/MS method after administration of a single oral dosage of IBR (50 mg/kg) in rats with or without SA pretreatment (40 mg/kg p.o. each day for 7 days, n = 6). The co-administration of IB... [more]
37002. LAPSE:2023.2129
Dusty Nanoliquid Flow through a Stretching Cylinder in a Porous Medium with the Influence of the Melting Effect
February 21, 2023 (v1)
Subject: Numerical Methods and Statistics
Keywords: dusty nanofluid, melting heat effect, porous medium, stretching cylinder
The melting effect, a type of heat transferal process, is a fascinating mechanism of thermo-physics. It is related to phase change issues that occur in several industrial mechanisms. Glass treatment, polymer synthesis, and metal processing are among these. In view of this, the current investigation explicates the flow of a dusty nanofluid through a stretching cylinder in a porous medium by considering the effect of the melting heat transfer phenomenon. Using the required similarity transformations, the governing partial differential equations (PDEs) showing the energy transference and fluid motion in both the liquid and dust phases were translated into ordinary differential equations (ODEs). The numerical solutions for the acquired ODEs were developed using the Runge−Kutta−Fehlberg method of fourth−fifth order (RKF-45) and the shooting process. Graphical representations were used to interpret the effects of the governing parameters, including the porosity parameter, the Eckert number,... [more]
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