The ability to take non-invasive Raman measurements presents a unique opportunity to use one Raman probe across multiple vessels in parallel, reducing costs but making measurements infrequent. Under these conditions, infrequent and irregular feedback signals can result in poor closed-loop control performance. This study addressed the issue of infrequent and irregular Raman measurements using a linear dynamic model developed from interpolated data to predict more frequent measurements of the controlled variable. The simulated monoclonal antibody production was sampled hourly with white noise added to the simulated glucose concentration to replicate real Raman measurements. The hourly samples were interpolated into 15 min intervals and a linear dynamic model was developed to predict the glucose concentration at 15 min intervals. These predicted values were then used in a feedback control loop by using model predictive control or a conventional proportional and integral controller to cont... [more]

During the construction of tunnels in saturated water-bearing sand stratum, water and mud inrush disasters often occur. Grouting is the most convenient and effective method to improve the mechanical properties of the soil and prevent groundwater seepage. The reasonableness of the Discrete Element Method (DEM) contact parameters is verified by comparing the repose angle test with that obtained by simulations. The grouting model of saturated water-bearing sand stratum was established based on the Volume of Fluid-Discrete Element Method (VOF-DEM). Then, the effects of sand stratum porosity and grouting pressure on grouting were discussed. The results show that (1) in dense sands, the permeation diffusion of the slurry dominates, whereas in loose sands, the compaction zone is well developed. (2) Loose sand has a wider propagation of stress and dense sand has a larger increase in the stress state. (3) In loose sand the slurry diffusion is significantly affected by gravity, whereas in dense... [more]

Actual diffusion activity function is an important metric utilized to describe the diffusion activities of a vacancy defect substance. In this paper, we propose a deep learning three-dimensional convolutional CNN model (D3-CNN). A 3D convolution has its kernel slides in three dimensions as opposed to two dimensions with 2D convolutions. 3D convolution is more suitable for three-dimensional data. We also propose an amplification learning technique to predict the actual diffusion activity of a vacancy defect substance, which is impacted by the geometrical parameters of the defect substance and the vacancy distribution function. In this model, the geometric parameters of a three-dimensional constructed vacancy defect substance are generated. The 3D dataset is obtained by the atoms diffusion defect (ADD) simulation model. The geometric parameters of the 3D vacancy defect substance are computed by the proposed amplification technique. The 3D geometric parameters and the diffusion activity v... [more]

The incursion of disruptive technologies, such as the Internet of Things, information technologies, cloud computing, digitalization and artificial intelligence, into current production processes has led to a new global industrial revolution called Industry 4.0 or Manufacturing 4.0. This new revolution proposes digitization from one end of the value chain to the other by integrating physical assets into systems and networks linked to a series of technologies to create value. Industry 4.0 has far-reaching implications for production systems and engineering education, especially in the training of mechatronic engineers. In order to face the new challenges of the transition from manufacturing 3.0 to Industry 4.0 and 5.0, it is necessary to implement innovative educational models that allow the systematic training of engineers. The competency-based education model has ideal characteristics to help mechatronic engineers, especially in the development of specific competencies. This article pr... [more]

The conformal loading effects of P3CT-Na polymers on ITO/glass samples were investigated using different concentrations of P3TC-Na/water solution, which significantly influenced the device efficiency of the resultant inverted perovskite solar cells. The obtained water-droplet contact angle images, surface morphological images, photoluminescence spectra and X-ray diffraction patterns show that the hydrophilic moiety of the P3CT-Na polymers plays an important role in the conformal loading effects, thereby resulting in a smoother perovskite crystalline film due to the formation of merged grains. It is noted that the average power conversion efficiency increases from 14.83% to 17.27% with a decrease in the concentration of the P3CT-Na/water solution from 60 wt% to 48 wt%.

The diagnosis of rolling bearing faults has become an increasingly popular research topic in recent years. However, many studies have been conducted based on sufficient training data. In the real industrial scene, there are some problems in bearing fault diagnosis, including the imbalanced ratio of normal and failure data and the amount of unlabeled data being far more than the amount of marked data. This paper presents a rolling bearing fault diagnosis method suitable for different working conditions based on simulating the real industrial scene. Firstly, the dataset is divided into the source and target domains, and the signals are transformed into pictures by continuous wavelet transform. Secondly, Wasserstein Generative Adversarial Nets-Gradient Penalty (WGAN-GP) is used to generate false sample images; then, the source domain and target domain data are input into the migration learning network with Resnet50 as the backbone for processing to extract similar features. Multi-Kernel M... [more]

Fast computation of the elastic deformation integrals of dry contact is accomplished using multigrid techniques. The method is called multi-level multi-integration, which enables the efficient numerical solution of contact pressure for large dry-contact problems. The computing effort can be reduced to O (NlogN) operations, compared to that of classical solution methods, O (N2). The fast integration technique can be straightforwardly applied to computing sub-surface stresses. As an example, the pressure and stress distribution of the contact of wire rope and friction lining, a large calculation due to the wire rope’s complicated construction, were fast solved. Subsequently, the friction lining’s transient temperature, when the wire rope was sliding, was solved using multigrid techniques.

The use of multiphase electric drives in industrial applications has increased in the last few years. These machines’ advantages over the three-phase system make them appropriate for harsh working situations. To increase their inherent reliability, some authors have been working in sensorless control schemes, where the absence of an encoder ensures proper system performance. Nevertheless, these sensorless control systems present some problems due to the uncertainties of the parameters. In this regard, using extended Kalman filters overcomes this situation, since Kalman filters consider the system error and measurement error in the estimation process. However, when the three-phase Kalman filters are extended to the five-phase case of study, the complexity of the problem increases substantially. In this work, the authors propose an extended Kalman filter, which discomposes the original state equation, reducing the complexity of the estimation stage. In addition, the system suppresses the... [more]

Species of the genus Artemisia mainly biosynthesize sesquiterpene lactones. Achillin is a guaianolide-type sesquiterpene lactone isolated from Artemisia ludoviciana; it has shown antibacterial and anti-inflammatory activities. In addition, achillin exhibits a significant chemosensitizing effect on hepatocellular carcinoma cells resistant to paclitaxel (PTX). The objective of this study was to establish a callus culture from different explants under conditions of light and total darkness to produce achillin. To obtain in vitro cultures, explants of leaves, nodes, internodes, and roots were used, and they were cultured in MS medium with 0.1 mg/L of kinetin (KIN) or benzyl amino purine (BAP) and/or naphthaleneacetic acid (NAA), 2,4-dichlorophenoxyacetic acid (2,4-D), indole-3-acetic acid (IAA) and 4-amino-3,5,6-trichloro-2-pyridine carboxylic acid (PIC) at 0.1 and 1.0 mg/L. Of all treatments, internodes with BAP (0.1 mg/L) and PIC (1.0 mg/L) grown under photoperiod showed the best friable... [more]

This paper presents the multi-objective optimization of a crude oil hydrotreating (HDT) process with a crude atmospheric distillation unit using data-driven models based on bootstrap aggregated neural networks. Hydrotreating of the whole crude oil has economic benefit compared to the conventional hydrotreating of individual oil products. In order to overcome the difficulty in developing accurate mechanistic models and the computational burden of utilizing such models in optimization, bootstrap aggregated neural networks are utilized to develop reliable data-driven models for this process. Reliable optimal process operating conditions are derived by solving a multi-objective optimization problem incorporating minimization of the widths of model prediction confidence bounds as additional objectives. The multi-objective optimization problem is solved using the goal-attainment method. The proposed method is demonstrated on the HDT of crude oil with crude distillation unit simulated using A... [more]

In the present study, we investigated and compared the effect of microwaves and freeze-drying methods on the dehydration and rehydration kinetics in the phenolic, anthocyanin, aroma profiles, and antioxidant properties of tree tomato fruit (Solanum betaceum). The tree tomatoes were dried using microwaves at 350 W, 500 W, and 650 W, and then freeze-dried. The obtained drying curves were processed to find the most suitable mathematical modeling among the different moisture ratio expressions. Total phenolics, total anthocyanins, total flavonoids total carotenoids, vitamin C, Ferric Reducing Antioxidant Power (FRAP), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) were tested. Using High performance Liquid Chromatography (HPLC), phenolic and anthocyanin compound profiles were identified. The aroma profile was analyzed using gas chromatography-MS. The Midilli model, among others, precisely describes the dehydration methodology of all used drying methods with the coefficient of determination R2 = 0... [more]

This work provides a case study on the indoor environment and ventilation rate of naturally ventilated research student rooms in Chinese universities. In the measured room, air temperature, relative humidity and carbon dioxide (CO2) concentration were monitored during the heating period for 4 weeks. The number of indoor occupants, occupied time of the room and window/door-opening cases were simultaneously recorded. Results showed the research student room was occupied for an average of 12.0 h each day. Due to a large indoor and outdoor temperature difference during the heating season, and occupants’ adaption to indoor environment, indoor occupants seldom open windows/doors for ventilation. Air exchange of the room only by air infiltration cannot meet the ventilation requirement. As a result, an average of 77.6% of measured CO2 data each day exceeded 1000 ppm during occupied time. In fact, according to CO2 data, it was observed that window/door opening could effectively decrease indoor... [more]

Steam is commonly used for heating in industrial production and transmitted through the steam network. Along with the decarbonization of energy generation and utilization, electric boiler and combined heat and power (CHP) became the alternatives for steam generation. Thus, the steam network is becoming tightly coupled with the power system, which brings new challenges in the simulation and operation of the combined electric and steam system (CESS). A novel simulation approach for CESS that can balance both the simulation accuracy and speed is proposed. Piecewise linearization of the saturated steam property is used for model simplification, which accelerates the simulation speed while ensuring the accuracy. Meanwhile, the heat loss of the steam network takes both condensate loss and heat dissipation into account, which further improves the accuracy of heat loss calculation. In view of model solving, two computation frameworks are provided for back-pressure and extraction condensing the... [more]

The presented article deals with the design of equipment for measuring and testing hydrostatic transducers. The presented design of the device is used for measuring and testing hydrostatic transducers in laboratory conditions, especially hydraulic pumps. This shortens the testing time, with a reduction in economic costs for testing the elements of the hydraulic circuit or testing the properties of pumps and hydraulic fluids. By simulating the operating conditions occurring in practice, it is possible to verify and evaluate the parameters of mobile energy means used in hydraulic mechanisms. The designed laboratory equipment is used for measuring and testing hydrostatic transducers and properties of hydraulic fluids. A verification measurement of the flow of the hydrostatic transducer was performed on the proposed laboratory equipment. The output of the measurements is a confirmation of the functionality of the designed equipment. The results of the verification measurement were compared... [more]

The online measurement of coal ash has overcome the shortcomings of chemical tests. However, there could be large fluctuations and errors in the results of online ash monitors because of the transient change in coal quality resulting from different geological conditions in the mining process. In this study, to resolve the problems of the dual-energy γ-ray online ash monitor in the Linhuan Coal Preparation Plant, we investigated the internal factors, such as the composition of multimineral and multicoal, and external factors, such as the moisture and impurities, which affect the measurement results of the coal ash monitor. Furthermore, we developed a mathematical model to determine the effect of relevant factors on the coefficient of the online ash monitor, which revealed the relationship between coal composition and the parameters of the ash monitor, ensuring the stable and accurate measurement of ash in clean coal. The method of determining parameters used in the case of coal blending... [more]

Sour water stripping can treat the sour water produced by crude oil processing, which has the effect of environmental protection, energy saving and emission reduction. This paper aims to reduce energy consumption of the unit by strengthening process parameter optimization. Firstly, the basic model is established by utilizing Aspen Plus, and the optimal model is determined by comparative analysis of back propagation neural network (BPNN), radial basis function neural network (RBFNN) and generalized regression neural network (GRNN) models. Then, the sensitivity analysis of Sobol is used to select the operating variables that have a significant influence on the energy consumption of the sour water stripping system. Finally, the particle swarm optimization (PSO) algorithm is used to optimize the operating conditions of the sour water stripping unit. The results show that the RBFNN model is more accurate than other models. Its network structure is 5-66-1, and the expected value has an appro... [more]

For the reduction in the electromagnetic noise level of three-phase induction motors, many empirical rules and analytical models have been established to select the matching scheme of pole and slot, but they are not fully applicable to five-phase squirrel cage induction motors (FSCIM). In this paper, combined with the slot-number phase diagram (SNPD), and the electromagnetic force-vibration-acoustic analytical model deduced in Part I, the influence of pole-slot schemes, including five-phase regular-size phase-belt and fractional-slot winding, on magnetic noise is analyzed. The feasibility of electromagnetic noise prediction is verified by finite element simulation and experiments. Taking a 4 kW FSCIM as a prototype, noise prediction is carried out for all the slot-number matching schemes with pole pairs not exceeding three. For two noise reduction targets, which reduce the maximum single-frequency noise in the steady-state operation and the average noise during startup, the pole-slot n... [more]

Hydraulic fracture morphology and propagation mode are difficult to predict in layers of the various lithological strata, which seriously affects exploitation efficiency. This paper studies the fundamental mechanical and microscopic properties of the two main interfaces in inter-salt shale reservoirs. On this basis, cement-salt combination samples with composite interfaces are prepared, and hydraulic fracturing tests are carried out under different fluid velocities, viscosity, and stress conditions. The result shows that the shale bedding and salt-shale interface are the main geological interfaces of the inter-salt shale reservoir. The former is filled with salt, and the average tensile strength is 0.42 MPa, c = 1.473 MPa, and φ = 19.00°. The latter is well cemented, and the interface strength is greater than that of shale bedding, with c = 2.373MPa and φ = 26.15°. There are three basic fracture modes for the samples with compound interfaces. Low-viscosity fracturing fluid and high-vis... [more]

Electromagnetic braking (EMBr) technology, as one of the most effective technologies in the continuous casting process, provides an effective tool for improving the internal and external defects of steel products. Specifically, the EMBr technology takes the benefit of the generation of Lorentz force to decrease flow instability, mold powder entrapment, and surface defects, if applied properly. For this purpose, to gain a clear understanding of the effect of EMBr technology on the continuous casting process, a commonly used EMBr technology, namely ruler EMBr technology, is applied in the current work to investigate the dynamic behaviors of molten steel flow and steel−slag interface fluctuation inside a slab mold. Furthermore, to obtain a desirable braking effect of the ruler EMBr technology, operational parameters including the magnetic flux density, submerged entry nozzle (SEN) depth, and magnetic pole location are numerically investigated. The results demonstrate that the braking effe... [more]

The color of wine is an important quality parameter essential for the first impression of consumers. The International Organization of Vine and Wine (OIV) recommends two methods to describe wine color: color calculation according to Glories and the determination of coordinates in the CIE L*a*b* color space. The measurement of wine color is often not feasible for winemakers because the required instrumentation is expensive and bulky. In this study, the influence of photometer settings on the calculated color was investigated based on 14 wines. Furthermore, the CIE L*a*b* and Glories system were compared using 56 red and 56 white wines. Photometer settings were found to influence the reproducibility of color determination. In addition, CIE L*a*b* system do not correlate in all wines with the Glories system and Glories probably provides less information about wine color. Using interpolation, CIE L*a*b* coordinates were calculated from single wavelength measurements taken by a small-sized... [more]

Ketoconazole (KZ) is a broad-spectrum drug used to treat fungal infections. Local use of ketoconazole has been associated with some side effects in healthy adults, especially local reactions, such as stinging, severe irritation, and itching. Moreover, the bioavailability of KZ after oral administration is low in tablets due to its low water solubility. In addition, oral administration of ketoconazole produces systemic exposure, associated with significant side effects, such as cholestatic and hepatocellular lesions. In an attempt to reduce hepatotoxicity, ketoconazole may be administered at the primary site of infection with cutaneous candidiasis, specifically on the skin tissue. However, the use of ketoconazole in topical dosage forms is limited by its high lipophilicity and extremely poor aqueous solubility (1 ng/mL), thus leading to the rare availability of topical dosage forms on the market. Therefore, a new approach to the effective delivery of ketoconazole to the site of infectio... [more]

This article deals with the regression analysis of the ultrasonic signal amplitude when the character of the reflection surface has been changed from a planar case to a sharp corner case. The experiment was performed at a measurement distance within the interval from 100 mm to 215 mm. A nonlinear correlation between the amplitude of the ultrasound signal and the measured distance was demonstrated. By analyzing the frequency spectra, a poor nonlinear correlation between the maximum frequency component and the distance vector was found for the sharp corner case versus the planar case, which proved similar nonlinear characteristics as the signal amplitude marker. The strong linear correlation in the distance difference vectors in the amplitude analysis of the ultrasound signal confirmed the hypothesis of a direct relationship between the reflection surface geometric characteristic and the polarity of the difference. The ultrasound signal was identified as a 3rd-order dynamic system. The n... [more]

Multiple graph and semi-supervision techniques have been successfully introduced into the nonnegative matrix factorization (NMF) model for taking full advantage of the manifold structure and priori information of data to capture excellent low-dimensional data representation. However, the existing methods do not consider the sparse constraint, which can enhance the local learning ability and improve the performance in practical applications. To overcome this limitation, a novel NMF-based data representation method, namely, the multiple graph adaptive regularized semi-supervised nonnegative matrix factorization with sparse constraint (MSNMFSC) is developed in this paper for obtaining the sparse and discriminative data representation and increasing the quality of decomposition of NMF. Particularly, based on the standard NMF, the proposed MSNMFSC method combines the multiple graph adaptive regularization, the limited supervised information and the sparse constraint together to learn the mo... [more]

Conservation of energy usage is essential in chemical process plants due to the expanded energy users and demands alongside the carry-on hike of energy prices. This study analyzed the performance of energy savings in a heat exchanger network (HEN). It is based on decreasing utility usage while increasing process-to-process heat exchange in HEN using a path combination approach at different heat recovery approach temperatures (HRATs). The approach generates different combined path options for heat shifting from utilities to exchangers in a HEN. In terms of cost targeting, the optimal HRAT in a HEN is determined for each path’s combination option. The study focused on the HEN of crude oil preheat trains. Shifting heat load between utilities implies adding and subtracting loads to and from exchangers in a HEN. Therefore, a minor retrofit to compensate for the heat transfer area is required for some HEN exchangers. The optimum HRAT corresponding to the lowest total cost was determined for... [more]

This article mainly considers the coexistence of physical sales channels and online sales channels. Online retailers with online sales channels consider whether to provide return policies and whether to provide consumers with return insurance. The research established four return strategy models that: do not provide returns; provide returns but do not provide return insurance; provide return insurance, but the cost is borne by online retailers; and provide return insurance, but the cost is borne by consumers. The authors then studied the online retailers’ optimal return and shipping insurance selection strategies. The results show that when the proportion of residual return value after the value reduction of unit returned products was large, online retailers set higher sales prices and provided return policies, while offline retailers needed to reduce sales prices in order to attract more consumers. When the consumer unit product return compensation was relatively large, online retaile... [more]