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Records with Subject: Modelling and Simulations
1361. LAPSE:2023.28302
A Novel Hybrid Model of CNN-SA-NGU for Silver Closing Price Prediction
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: CNN, deep learning, NGU, self-attention, silver prediction.
Silver is an important industrial raw material, and the price of silver has always been a concern of the financial industry. Silver price data belong to time series data and have high volatility, irregularity, nonlinearity, and long-term correlation. Predicting the silver price for economic development is of great practical significance. However, the traditional time series prediction models have shortcomings, such as poor nonlinear fitting ability and low prediction accuracy. Therefore, this paper presents a novel hybrid model of CNN-SA-NGU for silver closing price prediction, which includes conventional neural networks (CNNs), the self-attention mechanism (SA), and the new gated unit (NGU). A CNN extracts the feature of input data. The SA mechanism captures the correlation between different eigenvalues, thus forming new eigenvectors to make weight distribution more reasonable. The NGU is a new deep-learning gated unit proposed in this paper, which is formed by a forgetting gate and a... [more]
1362. LAPSE:2023.28298
A Development of an Induction Heating Process for a Jewelry Factory: Experiments and Multiphysics
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: Ansys Maxwell, finite element analysis, heat transfer, induction heating, jewelry factory, multiphysics, soldering process, thermal simulation.
This article reports a successful development of the induction heating process (IHP) in a jewelry factory based on experiments and multiphysics consisting of electromagnetic and thermal simulations. First, two experiments were set to measure essential parameters for result validation and multiphysics boundary condition settings. Then, the essential parameters were applied to multiphysics, and both simulation results revealed heat transfer, magnetic flux density (B) generated by the coil, and temperature (T) of the product. B and T were consistent with the experimental results and theory, confirming the reliability of the multiphysics and methodology. After that, all simulation results were analyzed to assess and optimize IHP in terms of the number of coil turns (N), positional placement of the product (P), and coil thickness (Th). Multiphysics revealed that the current operating condition with N = 3 is proper; however, the IHP can be improved more with coil and operating condition opti... [more]
1363. LAPSE:2023.28297
Mechanism of Surface Wettability of Nanostructure Morphology Enhancing Boiling Heat Transfer: Molecular Dynamics Simulation
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: boiling heat transfer, kinetic energy, nanostructure, potential energy, wettability.
In this paper, the interaction mechanism between the solid−liquid−gas interface phenomenon caused by nanostructure and surface wettability and boiling heat transfer is described, and the heat transfer theory of single wettable nanostructure surface and mixed wettable nanostructure surface is proposed. Through molecular dynamics simulation, the thermodynamic model of the wettable surface of nanostructures is established. The nanostructures are set as four rectangular lattice structures with a height of 18 Å. The solid atoms are platinum atoms, and the liquid atoms are argon atoms. The simulation results show that with the increase of surface hydrophilicity of nanostructures, the fluid temperature increases significantly, and the heat transfer at the interface is enhanced. With the increase in surface hydrophobicity of nanostructures, the atoms staying on the surface of nanostructures are affected by the hydrophobicity, showing a phenomenon of exclusion, and the evaporation rate in the e... [more]
1364. LAPSE:2023.28288
Numerical Simulation of Impinging Jet Drying Multiphase Flow in Gravure Printing Water-Based Ink Based on the Volume of Fluid Method
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: heat and mass transfer, impinging air jets drying, Simulation, water-based ink.
Gravure printing is widely used in food, pharmaceutical, and other packaging industries. As a green printing material, water-based ink has problems such as non-volatile and poor drying on non-absorbent packaging substrates, which has a great impact on its application. To solve these difficulties, this study adopts the volume of fluid (VOF) method and user-defined function (UDF) to establish a multiphase flow impinging air jets drying model of water-based ink in the gravure printing process, taking a water-based ink droplet as an example. The model was used to simulate the ink drying state in the impinging air jets region and analyze the effects of impinging air jets’ temperature and velocity, as well as ink viscosity and thickness, on the ink drying efficiency. Meanwhile, the heat and mass transfer mechanism between impinging air jets and water-based ink was investigated. The results show that the higher impinging air jet temperature and velocity, the faster the drying rate of the ink;... [more]
1365. LAPSE:2023.28280
On the Importance of Model Selection for CFD Analysis of High Temperature Gas-Solid Reactive Flow; Case Study: Post Combustion Chamber of HIsarna Off-Gas System
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: CFD modelling, combustion modelling, gas-solid reaction, HIsarna ironmaking, radiation modelling, turbulence modelling, turbulence-chemistry interaction.
In this paper a CFD analysis of HIsarna off-gas system for post combustion of CO-H2-carbon particle mixture is presented to evaluate the effect of different sub-models and parameters on the accuracy of predictions and simulation time. The effects of different mesh type, mesh grid size, radiation models, turbulent models, kinetic mechanism, turbulence chemistry interaction models, including and excluding gas-solid reactions, number of reactive solid particles are investigated in detail. Based on the accuracy of the predictions and agreement with counterpart measured values, the best combination is selected and conclusions are derived. It was found that radiation and turbulence chemistry interaction model have a major effect on the temperature and composition profile prediction along the studied off-gas system, compared to the variations in other models. The effect of these two models becomes even more evident when the temperature and fuel content of the flue gas are high.
1366. LAPSE:2023.28275
Analysis of the Shear Stresses in a Filling Line of Parenteral Products: The Role of Tubing
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: Computational Fluid Dynamics, filling line, parenteral products, shear stress.
Parenteral products appear to be sensitive to process conditions in bioprocessing steps, such as interfacial stress and shear stress. The combination of these elements is widely believed and proven to influence product stability, but the defined roles of these players in the product damage process have not yet been identified. The present work addresses a current industrial problem, by focusing on the analysis of shear stress on protein-based therapeutics flowing in tubing by means of Computational Fluid Dynamics simulations. The purpose of this article is not to pinpoint the mechanism triggering the damage of the product, but it represents the first step towards wider experimental investigations and introduces a new strategy to quantify the average shear stress. The field of scale-down approaches, used to scale the commercial process down to the laboratory level, is also explored. Since quality control is critical in the pharmaceutical realm, it is essential that the scale-down approa... [more]
1367. LAPSE:2023.28273
Recent Development and Future Prospective of Tiwari and Das Mathematical Model in Nanofluid Flow for Different Geometries: A Review
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: convective heat transfer, entropy generation, hybrid nanofluids, mathematical modeling geometries, nanofluids.
The rapid changes in nanotechnology over the last ten years have given scientists and engineers a lot of new things to study. The nanofluid constitutes one of the most significant advantages that has come out of all these improvements. Nanofluids, colloid suspensions of metallic and nonmetallic nanoparticles in common base fluids, are known for their astonishing ability to transfer heat. Previous research has focused on developing mathematical models and using varied geometries in nanofluids to boost heat transfer rates. However, an accurate mathematical model is another important factor that must be considered because it dramatically affects how heat flows. As a result, before using nanofluids for real-world heat transfer applications, a mathematical model should be used. This article provides a brief overview of the Tiwari and Das nanofluid models. Moreover, the effects of different geometries, nanoparticles, and their physical properties, such as viscosity, thermal conductivity, and... [more]
1368. LAPSE:2023.28269
Self-Sustaining Control Strategy for Proton-Exchange Membrane Electrolysis Devices Based on Gradient-Disturbance Observation Method
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: disturbance observation method, electrothermal-coupling dynamic model, gradient method, proton-exchange membrane electrolysis device, self-sustaining control.
This paper proposes a self-sustaining control model for proton-exchange membrane (PEM) electrolysis devices, aiming to maintain the temperature of their internal operating environment and, thus, improve the electrolysis efficiency and hydrogen production rate. Based on the analysis of energy−substance balance and electrochemical reaction characteristics, an electrothermal-coupling dynamic model for PEM electrolysis devices was constructed. Considering the influence of the input energy−substance and the output hydrogen and oxygen of PEM electrolysis devices on the whole dynamic equilibrium process, the required electrical energy and water molar flow rate are dynamically adjusted so that the temperature of the cathode and the anode is maintained near 338.15 K. The analytical results show that the hydrogen production rate and electrolysis efficiency are increased by 0.275 mol/min and 3.9%, respectively, by linearly stacking 100 PEM electrolysis devices to form a hydrogen production system... [more]
1369. LAPSE:2023.28268
A Model for the Flow Distribution in Dual Cell Density Monoliths
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: Computational Fluid Dynamics, dual cell density, flow distribution, monolith, substrate.
Monoliths are promising as catalytic structured supports due to their many operational advantages. Compared to pellets, monoliths offer low backpressure and good heat distribution, even at high flow rates. There is interest in the industry for improving temperature control in highly exothermic systems, such as the catalytic hydrogenation of CO2 for e-fuels synthesis. In this context, novel substrate shapes, such as non-homogeneous cell density monoliths, show good potential; however, to date, they have only been sparsely described. This work focuses on a dual cell density substrate and uses a computational model of a straight-channel monolith with two concentric regions to analyze its flow distribution. The central (core) and peripheral (ring) regions of the substrate differ in cell density in order to obtain a non-homogeneous cross-section. The model is validated against classical data in the literature and theoretical equations. Then, the flow fraction passing through each region of... [more]
1370. LAPSE:2023.28267
Device Testing: High-Efficiency and High-Uniformity Microwave Water Treatment System Based on Horn Antennas
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: Energy Efficiency, microwave heating, multiphysics simulation, saline wastewater, temperature uniformity, wastewater treatment.
Microwave heating has excellent potential for applications in wastewater treatment. This study proposes a highly efficient continuous liquid-phase microwave heating system to overcome the problems of low treatment capacity, low dynamic range of loads, and insufficient heating uniformity of the existing equipment. First, a quarter-wavelength impedance-matching layer improves heating efficiency, and the heating uniformity has been enhanced by horn antennas. Second, an experimental system is developed. The simulation and experimental results are consistent, with the microwave system achieving over 90% energy utilization for different thicknesses and concentrations of salt water. Finally, simulations are performed to analyze microwave efficiency and heating uniformity at different flow rates, salinities, dielectric properties, and sawtooth structures. The system can efficiently heat loads with a wide range of dielectric properties, including saline water. Generally, when the permittivity v... [more]
1371. LAPSE:2023.28266
Study on Verification Approach and Multicontact Points Issue When Modeling Cyperus esculentus Seeds Based on DEM
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: Cyperus esculentus seeds, multicontact points, the multisphere (MS) method, verification test, Young’s modulus.
In this paper, the Multisphere (MS) models of three varieties of Cyperus esculentus seeds are modeled based on DEM. In addition, for comparison, other particle models based on automatic filing in EDEM software are also introduced. Then, the direct shear test, piling test, bulk density test, and rotating hub test are used to verify the feasibility of particle models of Cyperus esculentus seeds that we proposed. By comparing the simulated results and experimental results, combined with the CPU computation time, the proposed particle models achieved better simulation accuracy with fewer filing spheres. According to simulation results, some limitation was present when using one single verification test; varieties of verification tests used could improve the verification reliability, and a more appropriate particle model could be selected. Additionally, the issue of multicontact points in the MS model was studied. The Hertz Mindlin (no slip) (HM) model and Hertz Mindlin new restitution (HMN... [more]
1372. LAPSE:2023.28245
CFD Modelling and Numerical Simulation of the Windage Characteristics of a High-Speed Gearbox Based on Negative Pressure Regulation
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: computational fluid dynamics (CFD), flow field characteristics, high-speed gear, negative pressure regulation, windage power loss.
Windage power loss plays a leading role in the total power loss of high-speed gears, which seriously affects the transmission efficiency of gear systems and leads to high energy consumption. This paper proposes a negative pressure regulation method to reduce windage power loss. Based on the computational fluid dynamics theory, the flow field distribution and windage power loss in the gearbox under different negative pressure conditions are studied, and the effect of the negative pressure environment and speed on the windage power loss is obtained. In order to further save calculation costs, an optimization algorithm of the BP neural network based on a genetic algorithm is proposed to effectively predict the windage power loss. The results show that the high-speed airflow near the tooth’s surface will produce a large pressure moment, which is the main cause of wind resistance loss. The windage power loss increases with the increase in the negative pressure or speed of the gearbox, but t... [more]
1373. LAPSE:2023.28243
Experimental Study and Molecular Simulation of the Effect of Temperature on the Stability of Surfactant Foam
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: CO2 foam fracturing, foam half-life, molecular dynamics, surfactant, viscosity.
Temperature changes in CO2 foam-fracturing construction can easily affect surfactant foam stability. To investigate the effect of temperature on the foam stability of different types of surfactants, this study measured the foam half-life and viscosity of four typical surfactants, CTAB, LAS-30, HSB1214, and TX-10, using a novel self-designed and built foam performance measurement device. The effects of temperature on foam half-life and viscosity were studied. The results show that as the temperature increased, the half-life shortened, and the viscosity of the liquid phase decreased, which led to a decrease in foam stability. Moreover, using Materials Studio, a type of molecular simulation software, an interfacial model of the foam film was constructed to calculate the IFE and the self-diffusion coefficient of water molecules at 300 ps after the equilibrium of the foam system to investigate the mechanism of temperature influence on the stability of the foam. The results show that, for CT... [more]
1374. LAPSE:2023.28241
Energy Consumption Optimization of Milk-Run-Based In-Plant Supply Solutions: An Industry 4.0 Approach
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: digital twin, in-plant supply, Industry 4.0, milk-run, routing, Scheduling.
Smart factories are equipped with Industry 4.0 technologies including smart sensors, digital twin, big data, and embedded software solutions. The application of these technologies contributes to better decision-making, and this real-time decision-making can improve the efficiency of both manufacturing and related logistics processes. In this article, the transformation of conventional milk-run-based in-plant supply solutions into a cyber−physical milk-run supply is described, where the application of Industry 4.0 technologies makes it possible to make real-time decisions regarding scheduling, routing, and resource planning. After a literature review, this paper introduces the structure of Industry 4.0 technologies supported by milk-run-based in-plant supply. A mathematical model of milk-run processes is described including both scheduling and routing problems of in-plant supply. This mathematical model makes it possible to analyze the impact of Industry 4.0 technologies on the efficien... [more]
1375. LAPSE:2023.28235
Variable-Coefficient Dynamic Modeling Method for a Ball Screw Feed System in the No-Extra-Load Running State
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: ball screw feed system, dynamic modeling method, kinematic joints, machine tool, variable coefficient.
In a ball screw feed system of high-speed/high-acceleration machine tools, large frictional and inertial forces may change the real contact state of the kinematic joints, resulting in changes in the contact and transmission stiffnesses and, hence, changes in the dynamic characteristics of the system. In this study, a variable−coefficient dynamic modeling method for a ball screw feed system is proposed, considering the influence of changes in the no-extra-load running states, such as position, speed, and acceleration. Based on Timoshenko beam elements with two nodes and four DOFs, an equivalent dynamic model of a ball screw feed system is established using the hybrid element method. The expression for the equivalent axial stiffness of individual kinematic joints is derived, considering the influence of the feed speed/acceleration under the no-extra-load running state of the system. In addition, the stiffness and mass of the screw shafts on both sides of the screw nut are calculated, con... [more]
1376. LAPSE:2023.28226
Thermodynamic Simulation of O Content Variation Roadmap in Submerged Arc Welding Process: From Droplet to Weld Metal
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: Calphad, flux, oxides, slag, submerged arc welding, welding simulation.
Submerged arc welding is a complex metallurgical system involving various phases with a temperature higher than 2000 °C. Since the hot weld pool is shielded beneath the flux, thermodynamic investigation on the O content variation during the welding process remains nebulous. Within this framework, a thermodynamic approach has been proposed to estimate the variation tendency of O content in metal during the overall submerged arc welding process. The modeling is based on the assumptions of Oxygen Layer Theory, Local Attained Equilibrium, and Scheil Solidification. The simulated and measured data show that this approach is capable of predicting the variation of the O content roadmap when typical CaO−Al2O3 based fluxes are employed. Then, factors pertinent to the level of O content are evaluated from thermodynamic perspectives. Additionally, it is revealed that the decomposition mechanisms of the oxides in welding can be constrained via the incumbent approach.
1377. LAPSE:2023.28225
Feasibility Analysis for the Direct Hydration of 1-Octene in a Catalytic Distillation Process Using Residual Curve Maps
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: 1-octene, feasibility analysis, kinetics, residual curve maps.
The very useful organic solvent 2-octanol is widely employed in the industry, and the direct hydration of olefins is an important method for its production. However, a slow transfer rate during a reaction due to the poor mutual solubility of the reactants is a problem; a cosolvent can be used to solve it. In this study, the feasibility of using the direct hydration of 1-octene via a catalytic distillation process using 1,4-dioxane as a cosolvent was investigated. First, the COSMOtherm program was used to identify and screen many typical cosolvents. Subsequently, the kinetics of the direct hydration reaction of 1-octene using 1,4-dioxane as a cosolvent and an HZSM-5 molecular sieve as the catalyst were determined experimentally. Finally, kinetic and thermodynamic models were utilized to create non-reactive and reactive residual curve maps to assess the feasibility of proceeding with the reaction. Applying a suitable Damköhler number (Da) value and the residual curve changes demonstrated... [more]
1378. LAPSE:2023.28223
Buildability Analysis of 3D Concrete Printing Process: A Parametric Study Using Design of Experiment Approach
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: 3D concrete printing, buildability, design of experiment, numerical modelling, parametric study.
Plastic collapse and buckling are the key structural failure criteria in 3D concrete printing (3DCP). This study aims to analyze the effect of different geometrical designs and printing factors on the buildability performance of 3DCP structures. Due to the high number of variables involved, the Design of Experiment (DOE) has been used to reduce the number of simulations. In geometrical design parameters, the structure’s design is more sensitive, followed by the width and length of the printed design. The buildability increases when we move from sharp corners to more stable structures like fillets and circular geometry. For geometrical design parameters, a maximum buildability of 74% of the designed height is achieved for circular design with the highest width and lowest diameter. For printing parameters, the highest buildability of 486 mm (81%) is achieved for the lower values of printing speed and layer height. The study analyzed failure phenomena of buckling and yield strength for th... [more]
1379. LAPSE:2023.28221
Evaluation of Relative Permeability Curves in Sandstone Core Flooding Using Computational Fluid Dynamics
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: carbon sequestration, Computational Fluid Dynamics, relative permeability.
Geological carbon sequestration is a proven method of safely storing carbon dioxide in formations, thereby reducing atmospheric carbon imprint and mitigating global warming. The relative permeability to carbon dioxide versus brine/water in geological formations determines flow characteristics of one fluid in the presence of another. The objective of this research is to evaluate the relative permeability to carbon dioxide in both the gas phase and the supercritical state in the presence of water in a Vedder sandstone core sample. The sandstone sample used is medium- to fine-grain arkosic artenite containing primarily quartz, potassium feldspar, plagioclase, and biotite. The effect of the viscosity ratio between the non-wetting phase and the wetting phase, on the relative permeability to the non-wetting phase, is studied. Computational fluid dynamics (CFD) is used for this study. Results show that with the same amount of irreducible water fraction, the endpoint relative permeability to t... [more]
1380. LAPSE:2023.28218
PCB Defect Detection Based on Deep Learning Algorithm
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: deep learning, defect, detection, PCB.
Printed circuit boards (PCBs) are primarily used to connect electronic components to each other. It is one of the most important stages in the manufacturing of electronic products. A small defect in the PCB can make the final product inoperable. Therefore, careful and meticulous defect detection steps are necessary and indispensable in the PCB manufacturing process. The detection methods can generally be divided into manual inspection and automatic optical inspection (AOI). The main disadvantage of manual detection is that the detection speed is too slow, resulting in a waste of human resources and costs. Thus, in order to speed up the production speed, AOI techniques have been adopted by many PCB manufacturers. Most current AOI mechanisms use traditional optical algorithms. These algorithms can easily lead to misjudgments due to different light and shadow changes caused by slight differences in PCB placement or solder amount so that qualified PCBs are judged as defective products, whi... [more]
1381. LAPSE:2023.28208
Analysis of Asphaltene Precipitation Models from Solubility and Thermodynamic-Colloidal Theories
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: asphaltene precipitation modeling, colloidal theories, EoS, model evaluation, polymer solutions.
Asphaltenes are known to cause problems related to flocculation, precipitation, and plugging, either in the formation, production lines, and processing equipment. Different models have been proposed to predict the thermodynamic conditions under which asphaltenes precipitate over the past years. This work analyses the performance of various models on their capability to match the literature experimental data of precipitated asphaltene mass fractions. Twenty-five different models based on equation-of-state (EoS), polymer solution, and thermodynamic-colloidal theories were identified. The performance/test datasets were collected and classified according to their pressure/temperature conditions, CO2, n-C5/n-C7 gas, and liquid titrations. Statistical analysis, including residuals, parity plots, and average absolute relative deviation (AARD, %), were used to compare the adequacy of selected models. Results confirmed the need for further model development for general applications over wide pr... [more]
1382. LAPSE:2023.28204
Groundwater Management Based on Time Series and Ensembles of Machine Learning
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: ensemble, groundwater, Machine Learning, time series.
Due to the necessity of effective water management, the issue of water scarcity has developed into a significant global issue. One way to collect water is through the water management method. The most common source of fresh water anywhere in the world is groundwater, which has developed into a significant global issue. Our previous research used machine learning (ML) for training models to classify groundwater quality. However, in this study, we used the time series and ensemble methods to propose a hybrid technique to enhance the multiclassification of groundwater quality. The proposed technique distinguishes between excellent drinking water, good drinking water, poor irrigation water, and very poor irrigation water. In this research, we used the GEOTHERM dataset, and we pre-processed it by replacing the missing and null values, solving the sparsity problem with our recommender system, which was previously proposed, and applying the synthetic minority oversampling technique (SMOTE). M... [more]
1383. LAPSE:2023.28190
Study on Mechanism of Oxygen Oxidation Leaching with Low Acid for High Acid Consumption Sandstone Uranium Deposit
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: coprecipitation, high acid consumption, in situ leaching of uranium, kinetics.
In view of the problems of high acid consumption, the blockage of ore-bearing beds caused by iron ion precipitation and a low leaching rate in the conventional acid leaching of a sandstone-type uranium deposit, the author put forward “low-acid and oxygen leaching technology” research. In order to further clarify the mechanism of leaching sandstone-type uranium ore with low acid and oxygen, the oxidation mechanism of ferrous ion under acidic conditions, the influencing factors of ferrous ion oxidation process, the kinetic simulation of oxygen oxidizing uranium minerals, and the interaction of uranium and iron precipitation in acidic solution were analyzed and studied, and the mechanism of oxygen oxidizing uranium and uranium leaching under low acid conditions was explored. The results show that under the condition of low acidity, the kinetics that ferrous oxidized by oxygen is between the first-order and second-order reaction, which can reduce the iron ion precipitation and then reduce... [more]
1384. LAPSE:2023.28189
Scalable mRNA Machine for Regulatory Approval of Variable Scale between 1000 Clinical Doses to 10 Million Manufacturing Scale Doses
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: autonomous operation, continuous biomanufacturing, digital twins, in vitro transcription, lipid nano particles, Machine Learning, mRNA vaccine manufacturing.
The production of messenger ribonucleic acid (mRNA) and other biologics is performed primarily in batch mode. This results in larger equipment, cleaning/sterilization volumes, and dead times compared to any continuous approach. Consequently, production throughput is lower and capital costs are relatively high. Switching to continuous production thus reduces the production footprint and also lowers the cost of goods (COG). During process development, from the provision of clinical trial samples to the production plant, different plant sizes are usually required, operating at different operating parameters. To speed up this step, it would be optimal if only one plant with the same equipment and piping could be used for all sizes. In this study, an efficient solution to this old challenge in biologics manufacturing is demonstrated, namely the qualification and validation of a plant setup for clinical trial doses of about 1000 doses and a production scale-up of about 10 million doses. Usin... [more]
1385. LAPSE:2023.28188
Study on Cavitation of Port Plate of Seawater Desalination Pump with Energy Recovery Function
April 11, 2023 (v1)
Subject: Modelling and Simulations
Keywords: cavitation, Computational Fluid Dynamics, energy recovery, seawater desalination.
To address the problem of low integration and efficiency of reverse osmosis desalination system, an energy-recovery type incurve multiple acting pump is developed with integrated functions of a high-pressure pump, energy recovery device and booster pump. In order to determine its flow range and suppress cavitation generation, a mathematical model of the port plate is established, combining the realizable k-ɛ turbulence model and the Schnerr-Sauer cavitation model to obtain the internal flow field characteristics of the port plate. The effects of different rotational speeds and inlet pressures on cavitation were analyzed to obtain the gas volume fraction distribution rules. The design is based on the pressure and mass flow monitoring test device to verify the numerical calculation results. The results show that the experimental and simulation data match accurately, and with the increase in speed and the decrease in inlet pressure, the cavitation phenomenon becomes serious and the flow c... [more]
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