Chromatography is widely used in biotherapeutics manufacturing, and the corresponding underlying mechanisms are well understood. To enable process control and automation, spectroscopic techniques are very convenient as on-line sensors, but their application is often limited by their sensitivity. In this work, we investigate the implementation of Raman spectroscopy to monitor monoclonal antibody (mAb) breakthrough (BT) curves in chromatographic operations with a low titer harvest. A state estimation procedure is developed by combining information coming from a lumped kinetic model (LKM) and a Raman analyzer in the frame of an extended Kalman filter approach (EKF). A comparison with suitable experimental data shows that this approach allows for the obtainment of reliable estimates of antibody concentrations with reduced noise and increased robustness.

Pipelines are one of the most efficient and economical methods of transporting fluids, such as oil, natural gas, and water. However, pipelines are often subject to leakage due to pipe corrosion, pipe aging, pipe weld defects, or damage by a third-party, resulting in huge economic losses and environmental degradation. Therefore, effective pipeline leak detection methods are important research issues to ensure pipeline integrity management and accident prevention. The conventional methods for pipeline leak detection generally need to extract the features of leak signal to establish a leak detection model. However, it is difficult to obtain actual leakage signal data samples in most applications. In addition, the operating modes of pipeline fluid transportation process often have frequent changes, such as regulating valves and pump operation. Aiming at these issues, this paper proposes a hybrid intelligent method that integrates kernel principal component analysis (KPCA) and cascade suppo... [more]

A novel fault diagnosis method is proposed, depending on a cloud service, for the typical faults in the hydraulic directional valve. The method, based on the Machine Learning Service (MLS) HUAWEI CLOUD, achieves accurate diagnosis of hydraulic valve faults by combining both the advantages of Principal Component Analysis (PCA) in dimensionality reduction and the eXtreme Gradient Boosting (XGBoost) algorithm. First, to obtain the principal component feature set of the pressure signal, PCA was utilized to reduce the dimension of the measured inlet and outlet pressure signals of the hydraulic directional valve. Second, a machine learning sample was constructed by replacing the original fault set with the principal component feature set. Third, the MLS was employed to create an XGBoost model to diagnose valve faults. Lastly, based on model evaluation indicators such as precision, the recall rate, and the F1 score, a test set was used to compare the XGBoost model with the Classification And... [more]

This work aimed to investigate the carbonaceous deposits on the surface of the coking chamber. Scanning electron microscopy (SEM), X-ray fluorescence spectrum (XRF), Fourier transform infrared spectrometer (FTIR), Raman spectroscopy, X-ray diffraction spectrum (XRD), and X-ray photoelectron spectroscopy (XPS) were applied to investigate the carbonaceous deposits. FTIR revealed the existence of carboxyl, hydroxyl, and carbonyl groups in the carbonaceous deposits. SEM showed that different carbonaceous deposit layers presented significant differences in morphology. XRF and XPS revealed that the carbonaceous deposits mainly contained C, O, and N elements, with smaller amounts of Al, Si, and Ca elements. It was found that in the formation of carbonaceous deposits, the C content gradually increased while the O and N elements gradually decreased. It was also found that the absorbed O2 and H2O took part in the oxidation process of the carbon skeleton to form the =O and −O− structure. The oxid... [more]

In recent years, magnetic nanoparticles (MNPs) have been widely used as a new material in biomedicine and other fields due to their broad versatility, and the quantitative detection method of MNPs is significantly important due to its advantages in immunoassay and single-molecule detection. In this study, a method and device for detecting the number of MNPs based on weak magnetic signal were proposed and machine learning methods were applied to the design of MNPs number detection method and optimization of detection device. Genetic Algorithm was used to optimize the MNPs detection platform and Simulated Annealing Neural Network was used to explore the relationship between different positions of magnetic signals and the number of MNPs so as to obtain the optimal measurement position of MNPs. Finally, Radial Basis Function Neural Network, Simulated Annealing Neural Network, and partial least squares multivariate regression analysis were used to establish the MNPs number detection model,... [more]

As the optimal linear filter and estimator, the Kalman filter has been extensively utilized for state estimation and prediction in the realm of lumped parameter systems. However, the dynamics of complex industrial systems often vary in both spatial and temporal domains, which take the forms of partial differential equations (PDEs) and/or delay equations. State estimation for these systems is quite challenging due to the mathematical complexity. This work addresses discrete-time Kalman filter design and realization for linear distributed parameter systems. In particular, the structural- and energy-preserving Crank−Nicolson framework is applied for model time discretization without spatial approximation or model order reduction. In order to ensure the time instance consistency in Kalman filter design, a new discrete model configuration is derived. To verify the feasibility of the proposed design, two widely-used PDEs models are considered, i.e., a pipeline hydraulic model and a 1D bounda... [more]

In this article, the statistical process monitoring problem of the Tennessee Eastman process is considered using deep learning techniques. This work is motivated by three limitations of the existing works for such problem. First, although deep learning has been used for process monitoring extensively, in the majority of the existing works, the neural networks were trained in a supervised manner assuming that the normal/fault labels were available. However, this is not always the case in real applications. Thus, in this work, autoassociative neural networks are used, which are trained in an unsupervised fashion. Another limitation is that the typical dataset used for the monitoring of the Tennessee Eastman process is comprised of just a small number of data samples, which can be highly limiting for deep learning. The dataset used in this work is 500-times larger than the typically-used dataset and is large enough for deep learning. Lastly, an alternative neural network architecture, whi... [more]

Monitoring the thermal behavior of distributed energy resources (DERs) network explores the dualism between thermal effects and electrical power flow. This paper proposes a design concept that monitors thermal conditions of DER grids, using ZigBee/GSM wireless sensor networks (WSNs) for real-time monitoring in rural and remote areas. The concept seeks to improve upon existing designs by integrating composite functions. The functions comprise temperature conditions monitoring, data acquisition, and wireless data transmission including data storage and abnormal conditions alert/notification for control solutions. Thus, the concept determines the thermal impact on the DERs integrated network. WSNs with temperature sensors LM35 are utilized to complement ZigBee and Global System for Mobile Communications (GSM) technologies as a communication assisted link. Temperatures are measured from solar Photovoltaic PV modules, wind turbine, distribution cables, protection control units, and energy s... [more]

Waterflooding is less effective at expanding reservoir production due to interwell thief zones. The thief zones may form during high water cut periods in the case of interconnected injectors and producers or lead to a total loss of injector fluid. We propose to identify the thief zone by using a support vector machine method. Considering the geological factors and development factors of the formation of the thief zone, the signal-to-noise ratio and correlation analysis method were used to select the relevant evaluation indices of the thief zone. The selected evaluation indices of the thief zone were taken as the input of the support vector machine model, and the corresponding recognition results of the thief zone were taken as the output of the support vector machine model. Through the training and learning of sample sets, the response relationship between thief zone and evaluation indices was determined. This method was used to identify 82 well groups in M oilfield, and the identifica... [more]

Data with characteristics like nonlinear and non-Gaussian are common in industrial processes. As a non-parametric method, k-nearest neighbor (kNN) rule has shown its superiority in handling the data set with these complex characteristics. Once a fault is detected, to further identify the faulty variables is useful for finding the root cause and important for the process recovery. Without prior fault information, due to the increasing number of process variables, the existing kNN reconstruction-based identification methods need to exhaust all the combinations of variables, which is extremely time-consuming. Our previous work finds that the variable contribution by kNN (VCkNN), which defined in original variable space, can significantly reduce the ratio of false diagnosis. This reliable ranking of the variable contribution can be used to guide the variable selection in the identification procedure. In this paper, we propose a fast kNN reconstruction method by virtue of the ranking of VCk... [more]

Waste cooking oils (WCO) recycling companies usually have economic losses for buying WCO not suitable for biodiesel production, e.g., WCO with high free acidity (FA). For this reason, the determination of FA of WCO by near infrared (NIR) spectroscopy was studied in this work to assess its potential for in situ application. To do this, FA of 45 WCO was measured by the classical titration method, which ranged between 0.15 and 3.77%. Then, the NIR spectra from 800 to 2200 nm of these WCO were acquired, and a partial least squares model was built, relating the NIR spectra to FA values. The accuracy of the model was quite high, providing r2 of 0.970 and a ratio of performance to deviation (RPD) of 4.05. Subsequently, a model using an NIR range similar to that provided by portable NIR spectrometers (950−1650 nm) was built. The performance was lower (r2 = 0.905; RPD = 2.66), but even so, with good accuracy, which demonstrates the potential of NIR spectroscopy for the in situ determination of... [more]

Changes in water level between the mainstems and tributaries of a river can create backflow effects that alter the representativeness of water-quality monitoring data. In South Korea, 16 multi-functional weirs intended to manage water levels were constructed on 4 major rivers as part of a restoration project. However, they are causing backwater effects in tributaries that coincide with poorer water-quality measurements at monitoring stations along these tributaries despite there being no change in upstream pollution sources. Therefore, this study developed a new methodology for verifying the representativeness of a water-quality monitoring network via spatiotemporal observations of electrical conductivity, self-organizing maps for monthly pattern analysis, locally weighted scatter plot smoothing for trend analysis, load duration curves, and numerical modeling. This approach was tested on the Wicheon River, a primary tributary of the Nakdong River, because the measured decline in water... [more]

In the last few decades, the Smart Grid paradigm presence has increased within power systems. These new kinds of networks demand new Operations and Planning approaches, following improvements in the quality of service. In this sense, the role of the Distribution Management System, through its Outage Management System, is essential to guarantee the network reliability. This system is responsible for minimizing the consequences arising from a fault event (or network failure). Obviously, knowing where the fault appears is critical for a good reaction of this system. Therefore, several fault location techniques have been proposed. However, most of them provide individual results, associated with specific testbeds, which make the comparison between them difficult. Due to this, a review of fault location methods has been done in this paper, analyzing them for their use on underground distribution lines. Specifically, this study is focused on an impedance-based method because their requiremen... [more]

This paper presents the results of studies aiming at the assessment and classification of wastewater using an electronic nose. During the experiment, an attempt was made to classify the medium based on an analysis of signals from a gas sensor array, the intensity of which depended on the levels of volatile compounds in the headspace gas mixture above the wastewater table. The research involved samples collected from the mechanical and biological treatment devices of a full-scale wastewater treatment plant (WWTP), as well as wastewater analysis. The measurements were carried out with a metal-oxide-semiconductor (MOS) gas sensor array, when coupled with a computing unit (e.g., a computer with suitable software for the analysis of signals and their interpretation), it formed an e-nose—that is, an imitation of the mammalian olfactory sense. While conducting the research it was observed that the intensity of signals sent by sensors changed with drops in the level of wastewater pollution; th... [more]

State of charge (SOC) and state of health (SOH) are key issues for the application of batteries, especially the absorbent glass mat valve regulated lead-acid (AGM VRLA) type batteries used in the idle stop start systems (ISSs) that are popularly integrated into conventional engine-based vehicles. This is due to the fact that SOC and SOH estimation accuracy is crucial for optimizing battery energy utilization, ensuring safety and extending battery life cycles. The dual extended Kalman filter (DEKF), which provides an elegant and powerful solution, is widely applied in SOC and SOH estimation based on a battery parameter model. However, the battery parameters are strongly dependent on operation conditions such as the SOC, current rate and temperature. In addition, battery parameters change significantly over the life cycle of a battery. As a result, many experimental pretests investigating the effects of the internal and external conditions of a battery on its parameters are required, sin... [more]

Early detection of an internal short circuit (ISCr) in a Li-ion battery can prevent it from undergoing thermal runaway, and thereby ensure battery safety. In this paper, a model-based switching model method (SMM) is proposed to detect the ISCr in the Li-ion battery. The SMM updates the model of the Li-ion battery with ISCr to improve the accuracy of ISCr resistance R I S C f estimates. The open circuit voltage (OCV) and the state of charge (SOC) are estimated by applying the equivalent circuit model, and by using the recursive least squares algorithm and the relation between OCV and SOC. As a fault index, the R I S C f is estimated from the estimated OCVs and SOCs to detect the ISCr, and used to update the model; this process yields accurate estimates of OCV and R I S C f . Then the next R I S C f is estimated and used to update the model iteratively. Simulation data from a MATLAB/Simulink model and experimental data verify that this algor... [more]

An impedance-based temperature estimation method is investigated considering the electrochemical non-equilibrium with short-term relaxation time for facilitating the vehicular application. Generally, sufficient relaxation time is required for battery electrochemical equilibrium before the impedance measurement. A detailed experiment is performed to investigate the regularity of the battery impedance in short-term relaxation time after switch-off current excitation, which indicates that the impedance can be measured and also has systematical decrement with the relaxation time growth. Based on the discussion of impedance variation in electrochemical perspective, as well as the monotonic relationship between impedance phase shift and battery internal temperature in the electrochemical equilibrium state, an exponential equation that accounts for both measured phase shift and relaxation time is established to correct the measuring deviation caused by electrochemical non-equilibrium. Then, a... [more]

The on-board sensor fault detection and isolation (FDI) system is essential to guarantee the reliability and safety of an aero engine. In this paper, a novel online sequential extreme learning machine with memory principle (MOS-ELM) is proposed for detecting, isolating, and reconstructing the fault sensor signal of aero engines. In many practical online applications, the sequentially coming data chunk usually possesses a characteristic of timeliness, and the overdue training data may mislead the subsequent learning process. The proposed MOS-ELM can improve the training process by introducing the concept of memory principle into the online sequential extreme learning machine (OS-ELM) to tackle the timeliness of the data chunk. Simulations on some time series problems and some benchmark databases show that MOS-ELM performs better in generalization performance, stability, and prediction accuracy than OS-ELM. The experiment results of the MOS-ELM-based sensor fault diagnosis system also ve... [more]

Gas turbines are widely used all over the world, in order to ensure the normal operation of gas turbines, it is necessary to monitor the condition of gas turbine and analyze the tested parameters to find the state information contained in parameters. There is a problem in gas turbine condition monitoring that how to locate the fault accurately if failure occurs. To solve the problem, this paper proposes a method to locate the fault of gas turbine components by evaluating the sensitivity of tested parameters to fault. Firstly, the tested parameters are decomposed by the kernel principal component analysis. Then construct the statistics of T2 and SPE in the principal elements space and residual space, respectively. Furthermore, the thresholds of the statistics must be calculated. The influence of tested parameters on faults is analyzed, and the degree of influence is quantified. The fault location can be realized according to the analysis results. The research results show that the propo... [more]

The methodology of profile monitoring combines both the model fitting and statistical process control (SPC) techniques. Over the past ten years, a variety of profile monitoring methods have been proposed and extensively investigated in terms of different process profiles. However, monitoring tasks still exhibit a primary problem in that the errors surrounding the functional relationship are frequently assumed to be independent within every single profile. However, the assumption of independence is an unrealistic assumption in many practical instances. In particular, within-profile autocorrelation often occurs in the profile data. To mitigate the within-profile autocorrelation, a monitoring method incorporating an autoregressive (AR)(1) model to cope with autocorrelation is proposed. In this paper, the reflow process with small samples in surface mount technology (SMT) is investigated. In Phase I, three different process models are compared in combination with the first-order autoregres... [more]

The Lithium-ion battery (Li-ion) has become the dominant energy storage solution in many applications, such as hybrid electric and electric vehicles, due to its higher energy density and longer life cycle. For these applications, the battery should perform reliably and pose no safety threats. However, the performance of Li-ion batteries can be affected by abnormal thermal behaviors, defined as faults. It is essential to develop a reliable thermal management system to accurately predict and monitor thermal behavior of a Li-ion battery. Using the first-principle models of batteries, this work presents a stochastic fault detection and diagnosis (FDD) algorithm to identify two particular faults in Li-ion battery cells, using easily measured quantities such as temperatures. In addition, models used for FDD are typically derived from the underlying physical phenomena. To make a model tractable and useful, it is common to make simplifications during the development of the model, which may con... [more]

Background—Polymer rapid tooling (PRT) inserts for injection molding (IM) are a cost-effective method for prototyping and low-volume manufacturing. However, PRT inserts lack the robustness of steel inserts, leading to progressive deterioration and failure. This causes quality issues and reduced part numbers. Approach—Case studies were performed on PRT inserts, and different failures were observed over the life of the tool. Parts molded from the tool were examined to further understand the failures, and root causes were identified. Findings—Critical parameters affecting the tool life, and the effect of these parameters on different areas of tool are identified. A categorization of the different failure modes and the underlying mechanisms are presented. The main failure modes are: surface deterioration; surface scalding; avulsion; shear failure; bending failure; edge failure. The failure modes influence each other, and they may be connected in cascade sequences. Originality—The original... [more]

At present, the research is still in the primary stage in the process of fault disturbance energy transfer in the multilevel modular converter based high voltage direct current (HVDC-MMC). An urgent problem is how to extract and analyze the fault features hidden in MMC electrical information in further studies on the HVDC system. Aiming at the above, this article analyzes the influence of AC transient disturbance on electrical signals of MMC. At the same time, it is found that the energy distribution of electrical signals in MMC is different for different arms in the same frequency bands after the discrete wavelet packet transformation (DWPT). Renyi wavelet packet energy entropy (RWPEE) and Renyi wavelet packet time entropy (RWPTE) are proposed and applied to AC transient fault feature extraction from electrical signals in MMC. Using the feature extraction results of Renyi wavelet packet entropy (RWPE), a novel recognition method is put forward to recognize AC transient faults using th... [more]

This paper proposed a fault-tolerant approach based on information fusion (IF) to automatically locate the transient voltage disturbance source (TVDS) in smart distribution grids. We first defined three credibility factors that will influence the reliability of the direction-judgments at each power quality monitor (PQM). Then we proposed two rules of influence and a verification factor for the distributed generation (DG) integration. Based on the two sets of direction-judgment criteria, a novel decision-making method with fault tolerance based on the IF theory is proposed for automatic location of the TVDS. Three critical schemes, including credibility fusion, conflict weakening, and correction for DG integration, have been integrated in the proposed fusion method, followed by a reliability evaluation of the location results. The proposed approach was validated on the IEEE 13-node test feeder, and the TVDS location results demonstrated the effectiveness and fault tolerance of the IF ba... [more]

Most power transformers operating in a power system possess oil-paper insulation. A serious defect of this type of insulation, which is associated with long operation time, is an increase in the moisture content. Moisture introduces a number of threats to proper operation of the transformer, e.g., ignition of partial discharges (PDs). Due to the varying temperature of the insulation system during the unit’s normal operation, a dynamic change (migration of water) takes place, precipitating the oil-paper system from a state of hydrodynamic equilibrium. This causes the PDs to be variable in time, and they may intensify or extinguish. Studies on model objects have been conducted to determine the conditions (temperature, humidity, time) that will have an impact on the ignition and intensity of the observed phenomenon of PDs. The conclusions of this study will have a practical application in the evaluation of measurements conducted in the field, especially in relation to the registration of... [more]