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Records with Type: Published Article
15329. LAPSE:2023.24125
A Novel Probabilistic Power Flow Algorithm Based on Principal Component Analysis and High-Dimensional Model Representation Techniques
March 27, 2023 (v1)
Subject: Numerical Methods and Statistics
Keywords: high-dimensional model representation, point estimate method, principal component analysis, probability power flow, renewable energy source
Because the penetration level of renewable energy sources has increased rapidly in recent years, uncertainty in power system operation is gradually increasing. As an efficient tool for power system analysis under uncertainty, probabilistic power flow (PPF) is becoming increasingly important. The point-estimate method (PEM) is a well-known PPF algorithm. However, two significant defects limit the practical use of this method. One is that the PEM struggles to estimate high-order moments accurately; this defect makes it difficult for the PEM to describe the distribution of non-Gaussian output random variables (ORVs). The other is that the calculation burden is strongly related to the scale of input random variables (IRVs), which makes the PEM difficult to use in large-scale power systems. A novel approach based on principal component analysis (PCA) and high-dimensional model representation (HDMR) is proposed here to overcome the defects of the traditional PEM. PCA is applied to decrease t... [more]
15330. LAPSE:2023.24124
Performance Assessment of Front-Mounted Beet Topper Machine for Biomass Harvesting
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: beet top cutting, Biomass, sugar beet, tractor–harvester aggregate
Sugar beet is an extensive crop of great agronomic value with significant productive and economic returns and Ukraine’s sugar beet accounts for about 5.1% of the overall world production. Sugar beets and the by-products resulting from its manufacturing transformation are a significant renewable energy resource. A new high-quality performance prototype of a sugar beet top harvester, front mounted on a tractor, was built by the authors in Ukraine. The aim of this study is to evaluate the main performance parameters related to the operation of this new machine. Field tests were carried out linking the prototype to a wheel tractor, whilst suitable sensors measured the significant kinematic and dynamic parameters, allowing experimental data collection to assess the machine’s performance parameters. The entire technological process of harvesting and transporting the beet tops to the beet top storage unit required power ranging from 6.42 to 17.65 kW. At the topmost tested forward speed, the r... [more]
15331. LAPSE:2023.24123
Dynamic Simulation and Energy Economic Analysis of a Household Hybrid Ground-Solar-Wind System Using TRNSYS Software
March 27, 2023 (v1)
Subject: Modelling and Simulations
Keywords: dynamic simulation, economic analysis, household hybrid system, TRNSYS software
The adoption of micro-scale renewable energy systems in the residential sector has started to be increasingly diffused in recent years. Among the possible systems, ground heat exchangers coupled with reversible heat pumps are an interesting solution for providing space heating and cooling to households. In this context, a possible hybridization of this technology with other renewable sources may lead to significant benefits in terms of energy performance and reduction of the dependency on conventional energy sources. However, the investigation of hybrid systems is not frequently addressed in the literature. The present paper presents a technical, energy, and economic analysis of a hybrid ground-solar-wind system, proving space heating/cooling, domestic hot water, and electrical energy for a household. The system includes vertical ground heat exchangers, a water−water reversible heat pump, photovoltaic/thermal collectors, and a wind turbine. The system with the building is modeled and d... [more]
15332. LAPSE:2023.24122
Halide Pb-Free Double−Perovskites: Ternary vs. Quaternary Stoichiometry
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: ab-initio ground and excited state analysis, lead-free inorganic halide perovskites, optoelectronic applications, photovoltaics
In view of their applicability in optoelectronics, we review here the relevant structural, electronic, and optical features of the inorganic Pb-free halide perovskite class. In particular, after discussing the reasons that have motivated their introduction in opposition to their more widely investigated organic-inorganic counterparts, we highlight milestones already achieved in their synthesis and characterization and show how the use of ab initio ground and excited state methods is relevant in predicting their properties and in disclosing yet unsolved issues which characterize both ternary and quaternary stoichiometry double-perovskites.
15333. LAPSE:2023.24121
Bio-Inspired Rotor Design Characterization of a Horizontal Axis Wind Turbine
March 27, 2023 (v1)
Subject: Modelling and Simulations
Keywords: bio-inspired wind turbines, Computational Fluid Dynamics, wind turbine, wind turbines performance
In this paper, the performance of a biomimetic wind rotor design inspired by Petrea Volubilis seed is presented. Experimentation for this rotor is configured as a horizontal axis wind turbine (HAWT) and numerical analysis is done in order to obtain performance curves with the open-source computational fluid dynamics (CFD) software OpenFoam®. Numerical analysis and experimental results are compared for power Coefficient (Cp) and thrust coefficient (CT). The biomimetic rotor analysis is also compared with experimental results exposed by Castañeda et al. (2011), who were the first to develop those experimentations with this new rotor design. Computational fluid dynamics simulations were performed using an incompressible large Edyy simulation (LES) turbulence models with a localized sub-grid scale (SGS) dynamic one-equation eddy-viscosity. A dynamic mesh based on an arbitrary mesh interface (AMI) was used to simulate rotation and to evaluate flow around rotor blades in order to accurately... [more]
15334. LAPSE:2023.24120
The Philippines’ and Singapore’s Journeys towards Liberalised Electricity Supply Industries—Takeaways for Malaysia
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: ASEAN, electricity liberalisation, electricity unbundling, Energy Efficiency, energy security, energy sustainability, regional electricity market
Malaysia is in the process of liberalising its electricity supply industry (ESI) further, with the second reform series announced in September 2018. If everything goes as planned, Malaysia would be the third country in the Association of Southeast Asia Nations (ASEAN) to have a fully liberalised ESI after the Philippines and Singapore. A number of initiatives have been in the pipeline to be executed and a lot more will be planned. At this juncture, it is important for Malaysia to look for the best practices and lessons that can be learnt from the experience of other countries that have successfully liberalised their ESIs. Being in the same region, it is believed that there is a lot that Malaysia can learn from the Philippines and Singapore. This paper therefore presents and deliberates on the chronological development of the countries’ progressive journeys in liberalising their ESIs. The aim is to discern the good practices, the challenges as well as the lessons learnt from these trans... [more]
15335. LAPSE:2023.24119
Unraveling the Properties of Biomass-Derived Hard Carbons upon Thermal Treatment for a Practical Application in Na-Ion Batteries
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: Biomass, hard carbon, sodium-ion batteries, valorization
Biomass is gaining increased attention as a sustainable and low-cost hard carbon (HC) precursor. However, biomass properties are often unexplored and unrelated to HC performance. Herein, we used pine, beechwood, miscanthus, and wheat straw precursors to synthesize HCs at 1000 °C, 1200 °C and 1400 °C by a two-steps pyrolysis treatment. The final physicochemical and electrochemical properties of the HC evidenced dissimilar trends, mainly influenced by the precursor’s inorganic content, and less by the thermal treatment. Pine and beechwood HCs delivered the highest reversible capacity and coulombic efficiency (CE) at 1400 °C of about 300 mAh·g−1 and 80%, respectively. This performance can be attributed to the structure derived from the high carbon purity precursors. Miscanthus and wheat straw HC performance was strongly affected by the silicon, potassium, and calcium content in the biomasses, which promoted simultaneous detrimental phenomena of intrinsic activation, formation of a silicon... [more]
15336. LAPSE:2023.24118
Underground Pumped-Storage Hydropower (UPSH) at the Martelange Mine (Belgium): Underground Reservoir Hydraulics
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: Energy Storage, numerical modeling, Renewable and Sustainable Energy, underground pumped storage hydropower, water transients
The intermittent nature of most renewable energy sources requires their coupling with an energy storage system, with pumped storage hydropower (PSH) being one popular option. However, PSH cannot always be constructed due to topographic, environmental, and societal constraints, among others. Underground pumped storage hydropower (UPSH) has recently gained popularity as a viable alternative and may utilize abandoned mines for the construction of the lower reservoir in the underground. Such underground mines may have complex geometries and the injection/pumping of large volumes of water with high discharge could lead to uneven water level distribution over the underground reservoir subparts. This can temporarily influence the head difference between the upper and lower reservoirs of the UPSH, thus affecting the efficiency of the plant or inducing structural stability problems. The present study considers an abandoned slate mine in Martelange in Southeast Belgium as the lower, underground,... [more]
15337. LAPSE:2023.24117
An Experimental Study of the Sweep Frequency Impedance Method on the Winding Deformation of an Onsite Power Transformer
March 27, 2023 (v1)
Subject: Process Control
Keywords: short-circuit impedance (SCI), sweep frequency impedance (SFI), transformer winding, winding resistance measurement
Power transformers are one of the most important devices in electrical networks. The safety operation of the transformers directly affects the reliability of the power system. To diagnose the internal deformation of the transformer as soon as possible is of great significance. As a new technique, sweep frequency impedance (SFI) method has been used to detect the short-circuit fault of the transformer winding. However, the SFI method is still in the early stage and more experimental tests are needed to further demonstrate its accuracy in the detection of other types of winding faults. Therefore, in this paper, the SFI method is investigated to diagnose an open-circuit fault of an onsite transformer. By deeply analyzing the SFI curves and SFI values at power frequency obtained by the SFI test, the open-circuit fault of this transformer winding is determined. Meanwhile, the accuracy of the diagnostic results based on the SFI method is validated by introducing the results of the short-circ... [more]
15338. LAPSE:2023.24116
Optimal Sizing of Fuel Cell Hybrid Power Sources with Reliability Consideration
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: design methodology, fuel cell/battery, hybrid power source, optimal sizing, reliability assessment
This paper addresses the issue of optimal sizing reliability applied to a fuel cell/battery hybrid system. This specific problem raises the global problem of strong coupling between hardware and control parameters. To tackle this matter, the proposed methodology uses nested optimization loops. Furthermore, to increase the optimal design relevance, a reliability assessment of the optimal sizing set is introduced. This new paradigm enables showing the early impact of the reliability criteria on design choices regarding energetic performance index. It leads to a smart design methodology permitting to avoid complexity and save computing time. It considerably helps design engineers set up the best hybridization rate and enables practicing tradeoffs, including reliability aspects in the early design stages.
15339. LAPSE:2023.24115
Analysis of the Influence of Diesel Spray Injection on the Ignition and Soot Formation in Multiple Injection Strategy
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: combustion, Diesel, ignition, multiple injections, optical techniques, spray
Multiple injection strategies have increased their capabilities along with the evolution of injection system technologies up to the point that nowadays it is possible to inject eight different pulses, permitting to improve the engine performance, and consequently, emissions. The present work was realized for two simplified strategies: a pilot-main and a main-post, in order to analyze the influence of an auxiliary pulse on the main and otherwise, in reactive conditions for two pilot/post quantities and four hydraulic dwell times. The study was carried out by employing two optical techniques: diffused back-illumination with flame bandpass chemiluminescence for measuring soot, represented by soot-maps distribution, and single-pass schlieren for ignition delay (ID). Furthermore, a novel methodology for decoupling the start of combustion (SOC) of the second pulse was developed and successfully validated. From the ignition delay results, it was found for all test points that the pilot inject... [more]
15340. LAPSE:2023.24114
Hydrogen Storage Properties of Mg-Ni Alloys Processed by Fast Forging
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: eutectic alloys, forging, hydrogen storage, metal hydrides, Mg-Ni, severe plastic deformation
Fast forging of compacts made up of Mg and Ni powders is shown to be an effective method to induce severe plastic deformation with improved H2 sorption properties. Here, using such processed samples, a comprehensive analysis of the sorption properties reveals that the first hydrogenation sequence significantly depends on the forging temperature, through different microstructures. More in detail, no phase transformation occurs upon cold forging, while solid-state reaction leads to the formation of the Mg2Ni intermetallic compound upon forging above 400 °C. Forging below the brittle-to-ductile transition (225−250 °C) leads to faster H2 uptake upon first absorption owing to a more textured fiber along the c-axis and internal strains which promote hydrogen diffusion through the bulk material. Desorption kinetics remain slower with low-temperature forging, despite Ni recombining to form Mg2Ni during the first desorption. After several cycles, a two-step behavior is observed with a fast abso... [more]
15341. LAPSE:2023.24113
Frequency Stability Evaluation in Low Inertia Systems Utilizing Smart Hierarchical Controllers
March 27, 2023 (v1)
Subject: Process Control
Keywords: distributed energy resources, disturbance conditions, frequency controller, frequency stability, low inertia
The high penetration of the Renewable Energy Sources and other emerging technologies likely to be installed in future power grids will pose new operational challenges to grid operators. One of the main issues expected to affect the operation of the power grid is the impact of inverter-based technologies to the power system inertia and, hence, to system stability. Consequently, the main challenge of the future grid is the evaluation of the frequency stability in the presence of inverter-based systems and how the aforementioned technology can support frequency stability without the help of the rotating masses of the traditional power grid systems. To assess the above problem, this paper proposes a methodology to evaluate the frequency stability in a projection of the real distribution grid in Cyprus with the time horizon to be the year 2030. The power grid under investigation is evaluated with and without the presence of smart hierarchical controllers for providing support to the power s... [more]
15342. LAPSE:2023.24112
Economic Management Based on Hybrid MPC for Microgrids: A Brazilian Energy Market Solution
March 27, 2023 (v1)
Subject: Process Control
Keywords: Brazilian energy market, microgrids, mixed logical dynamic systems, Model Predictive Control
This paper proposes a microgrid central controller (MGCC) solution to the energy management problem of a renewable energy-based microgrid (MG). This MG is a case study from the Brazilian energy market context and, thus, has some operational particularities and rules to be obeyed. The MGCC development was based on a hybrid model predictive control (HMPC) strategy using the mixed logical dynamic (MLD) approach to deal with logical constraints within the HMPC structure, which results in a mixed integer programming (MIP) problem. The development of the solution is done through economic and dynamic modeling of the MG components; furthermore, it also takes into account the energy compensation rules of the Brazilian energy market and the white energy tariff. These conditions are specified through a set of MLD constraints. The effectiveness and performance of the proposed solution are evaluated through high-fidelity numerical simulation.
15343. LAPSE:2023.24111
Extending the Application of the Smart Readiness Indicator—A Methodology for the Quantitative Assessment of the Load Shifting Potential of Smart Districts
March 27, 2023 (v1)
Subject: Energy Management
Keywords: demand response, Energy Efficiency, energy flexibility, energy performance of buildings directive, load shifting, smart buildings, smart districts, smart grids, smart readiness indicator
In 2018, the revised Energy Performance of Buildings Directive (EPBD) included for the first time the application of a smart readiness indicator (SRI). Based on the fact that load shifting in and across buildings plays an increasingly important role to improve efficiency and alleviate the integration of renewable energy systems, the SRI is also aimed at providing an indication of how well buildings can interact with the energy grids. With the clustering of buildings into larger entities, synergies related to the integration of renewable energy and load shifting can be efficiently exploited. However, current proposals for the SRI focus mainly on qualitative appraisals of the smartness of buildings and do not include the wider context of the districts. Quantitative approaches that can be easily applied at an early planning stage are still mostly missing. To optimize infrastructure decisions on a larger scale, a quantifiable perspective beyond the building level is necessary to evaluate a... [more]
15344. LAPSE:2023.24110
Investigative Coupled Thermo-Hydro-Mechanical Modelling Approach for Geothermal Heat Extraction through Multistage Hydraulic Fracturing from Hot Geothermal Sedimentary Systems
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: enhanced geothermal system, heat extraction, multiple hydraulic fracturing, numerical simulation, stress shadow, THM coupling
The meaningful utilization of artificially created multiple fractures in tight formations is associated with the performance behavior of such flow channels, especially in the case of thermal energy extraction from sedimentary geothermal system. In this study, an innovative idea is presented to develop a numerical model for geothermal energy production based on concrete physical performance of an artificially created tensile multi-fracture system in a simplified manner. The state-of-the-art software FLAC3Dplus-TOUGH2MP-TMVOC are integrated to develop a coupled thermo-hydro-mechanical (THM) fictive model for constructing a multi-fracture scheme and estimating heat extraction performance. By incorporating the actual fracture width of newly created subsequent fracture under the effect of stress shadow, cubic law is implemented for fluid flow and geothermal energy production. The results depict that fracture spacing plays a vital role in the energy contribution through multiple fractures. A... [more]
15345. LAPSE:2023.24109
Design of Nanomaterials for Hydrogen Storage
March 27, 2023 (v1)
Subject: Materials
Keywords: elastic strain, hydrogen storage, interface, microstructure, nanomaterial, nanoparticle, thin film, transmission electron microscopy
The interaction of hydrogen with solids and the mechanisms of hydride formation experience significant changes in nanomaterials due to a number of structural features. This review aims at illustrating the design principles that have recently inspired the development of new nanomaterials for hydrogen storage. After a general discussion about the influence of nanomaterials’ microstructure on their hydrogen sorption properties, several scientific cases and hot topics are illustrated surveying various classes of materials. These include bulk-like nanomaterials processed by mechanochemical routes, thin films and multilayers, nano-objects with composite architectures such as core−shell or composite nanoparticles, and nanoparticles on porous or graphene-like supports. Finally, selected examples of recent in situ studies of metal−hydride transformation mechanisms using microscopy and spectroscopy techniques are highlighted.
15346. LAPSE:2023.24108
Enabling Methodologies for Predictive Power System Resilience Analysis in the Presence of Extreme Wind Gusts
March 27, 2023 (v1)
Subject: Modelling and Simulations
Keywords: dynamic Bayesian network, Markov model, power systems resilience, probabilistic modeling, resilience models, smart grid
Modern power system operation should comply with strictly reliability and security constraints, which aim at guarantee the correct system operation also in the presence of severe internal and external disturbances. Amongst the possible phenomena perturbing correct system operation, the predictive assessment of the impacts induced by extreme weather events has been considered as one of the most critical issues to address, since they can induce multiple, and large-scale system contingencies. In this context, the development of new computing paradigms for resilience analysis has been recognized as a very promising research direction. To address this issue, this paper proposes two methodologies, which are based on Time Varying Markov Chain and Dynamic Bayesian Network, for assessing the system resilience against extreme wind gusts. The main difference between the proposed methodologies and the traditional solution techniques is the improved capability in modelling the occurrence of multipl... [more]
15347. LAPSE:2023.24107
Smart Energy Management of Residential Microgrid System by a Novel Hybrid MGWOSCACSA Algorithm
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: crow search algorithm, energy management, grey wolf optimizer, microgrid, renewable energy sources, sine cosine algorithm
Optimal scheduling of distributed energy resources (DERs) of a low-voltage utility-connected microgrid system is studied in this paper. DERs include both dispatchable fossil-fueled generators and non-dispatchable renewable energy resources. Various real constraints associated with adjustable loads, charging/discharging limitations of battery, and the start-up/shut-down time of the dispatchable DERs are considered during the scheduling process. Adjustable loads are assumed to the residential loads which either operates throughout the day or for a particular period during the day. The impact of these loads on the generation cost of the microgrid system is studied. A novel hybrid approach considers the grey wolf optimizer (GWO), sine cosine algorithm (SCA), and crow search algorithm (CSA) to minimize the overall generation cost of the microgrid system. It has been found that the generation costs rise 50% when the residential loads were included along with the fixed loads. Active participa... [more]
15348. LAPSE:2023.24106
Numerical Study on the Gravity Effect on Heat Transfer of Supercritical CO2 in a Vertical Tube
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: convective heat transfer, gravity effect, numerical study, supercritical CO2, vertical flow
The effects of gravity on the heat transfer performance of supercritical CO2 flowing within a vertical tube with a diameter of 4.75 mm are numerically studied in this paper. The main objectives are to comprehensively investigate the action of gravity and buoyancy on the supercritical heat transfer. An effective numerical method, which employs a modified Shear Stress Transfer k-ω model (SST k-ω), is applied at various gravity conditions. It is found that, for both upward and downward flows, the heat transfer of supercritical CO2 is improved with increased gravity magnitude. The effect of gravity on heat transfer are more pronounced under a low mass flux condition than that under a high mass flux condition and it is closely related to the variations of thermal properties. For the upward flow, the increased gravity magnitude accelerates the near wall fluid and creates a classic “M-shaped” radial velocity distribution. For the downward flow, the increased gravity magnitude decelerates the... [more]
15349. LAPSE:2023.24105
Improving Fuel Economy and Engine Performance through Gasoline Fuel Octane Rating
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: fuel economy, knock sensor, knocking, octane number, performance, spark-ignition, vehicle acceleration
The octane number is a measure of the resistance of gasoline fuels to auto-ignition. Therefore, high octane numbers reduce the engine knocking risk, leading to higher compression threshold and, consequently, higher engine efficiencies. This allows higher compression ratios to be considered during the engine design stage. Current spark-ignited (SI) engines use knock sensors to protect the engine from knocking, usually adapting the operation parameters (boost pressure, spark timing, lambda). Moreover, some engines can move the settings towards optimized parameters if knock is not detected, leading to higher performance and fuel economy. In this work, three gasolines with different octane ratings (95, 98 and 100 RON (research octane number)) were fueled in a high-performance vehicle. Tests were performed in a chassis dyno at controlled ambient conditions, including a driving sequence composed of full-load accelerations and two steady-state modes. Vehicle power significantly increased with... [more]
15350. LAPSE:2023.24104
Absorption of Cu(II) and Zn(II) from Aqueous Solutions onto Biochars Derived from Apple Tree Branches
March 27, 2023 (v1)
Subject: Environment
Keywords: Adsorption, aqueous solution, biochar, heavy metal, isotherms, kinetics
The aim of this study was to investigate the adsorption of Cu(II) and Zn(II) onto apple tree branches biochar (BC) produced at 300, 400, 500 and 600 °C (BC300, BC400, BC500, and BC600), respectively. The effect of adsorbent dosage, pH value, contact time, initial concentration of Cu(II) or Zn(II), and temperature on the adsorption process were investigated. The result showed that 5 g BC·L−1 was the optimal dosage to remove Cu(II) and Zn(II) from wastewater and the maximum adsorption efficiency was achieved at a pH of 5.0 for all the BCs when the initial concentration of Cu(II) and Zn(II) were 64 and 65 mg L−1, respectively. Adsorption kinetics and isotherm experiments showed that the pseudo-second order equation and the Langmuir isotherm could best describe the adsorption process, indicating that the adsorption of Cu(II) and Zn(II) onto BCs were monolayer processes and chemisorption was the rate limiting step. The values of ΔG0 for the absorption of Cu(II) and Zn(II) on all BCs were ne... [more]
15351. LAPSE:2023.24103
Hydrochloric Acid Modification and Lead Removal Studies on Naturally Occurring Zeolites from Nevada, New Mexico, and Arizona
March 27, 2023 (v1)
Subject: Materials
Keywords: acid modification, clinoptilolites, heavy metals, lead removal, purification, toxic substances
Four naturally occurring zeolites were examined to verify their assignments as chabazites AZLB-Ca and AZLB-Na (Bowie, Arizona) and clinoptilolites NM-Ca (Winston, New Mexico) and NV-Na (Ash Meadows, Nevada). Based on powder X-ray diffraction, NM-Ca was discovered to be mostly quartz with some clinoptilolite residues. Treatment with concentrated HCl (12.1 M) acid resulted in AZLB-Ca and AZLB-Na, the chabazite-like species, becoming amorphous, as confirmed by powder X-ray diffraction. In contrast, NM-Ca and NV-Na, which are clinoptilolite-like species, withstood boiling in concentrated HCl acid. This treatment removes calcium, magnesium, sodium, potassium, aluminum, and iron atoms or ions from the framework while leaving the silicon framework intact as confirmed via X-ray fluorescence and diffraction. SEM images on calcined and HCl treated NV-Na were obtained. BET surface area analysis confirmed an increase in surface area for the two zeolites after treatment, NM-Ca 20.0(1) to 111(4) m2/... [more]
15352. LAPSE:2023.24102
Interactive Effects in Two-Droplets Combustion of RP-3 Kerosene under Sub-Atmospheric Pressure
March 27, 2023 (v1)
Subject: Energy Systems
Keywords: high-speed cinematography, interactive effects, kerosene droplets, microexplosion, sub-atmospheric pressure
To improve our understanding of the interactive effects in combustion of binary multicomponent fuel droplets at sub-atmospheric pressure, combustion experiments were conducted on two fibre-supported RP-3 kerosene droplets at pressures from 0.2 to 1.0 bar. The burning life of the interactive droplets was recorded by a high-speed camera and a mirrorless camera. The results showed that the flame propagation time from burning droplet to unburned droplet was proportional to the normalised spacing distance between droplets and the ambient pressure. Meanwhile, the maximum normalised spacing distance from which the left droplet can be ignited has been investigated under different ambient pressure. The burning rate was evaluated and found to have the same trend as the single droplet combustion, which decreased with the reduction in the pressure. For every experiment, the interactive coefficient was less than one owing to the oxygen competition, except for the experiment at L/D0 = 2.5 and P = 1.... [more]
15353. LAPSE:2023.24101
Formulation, In Vitro and In Vivo Evaluation of Gefitinib Solid Dispersions Prepared Using Different Techniques
March 27, 2023 (v1)
Subject: Biosystems
Keywords: fusion method, gefitinib, microwave method, pharmacokinetics, polymeric carriers, solid dispersion
Gefitinib (Gef) is a poorly water-soluble antitumor drug, which shows poor absorption/bioavailability after oral administration. Therefore, this study was carried out to develop Gef solid dispersions (SDs) using different carriers and different techniques in order to enhance its dissolution and oral absorption/bioavailability. Various SD formulations of Gef were established using fusion and microwave methods utilizing Soluplus, Kollidone VA64, and polyethylene glycol 4000 (PEG 4000) as the carriers. Developed SDs of Gef were characterized physicochemically and evaluated for in vitro dissolution and in vivo pharmacokinetic studies. The physicochemical evaluation revealed the formation of Gef SDs using fusion and microwave methods. In vitro dissolution studies indicated significant release of Gef from all SDs compared to the pure Gef. Optimized SD of Gef (S2-MW) presented significant release of Gef (82.10%) compared with pure Gef (21.23%). The optimized Gef SD (S2) was subjected to in vi... [more]
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