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Records with Subject: Modelling and Simulations
Showing records 4862 to 4886 of 5729. [First] Page: 1 192 193 194 195 196 197 198 199 200 Last
Unsteady Natural Convection in an Initially Stratified Air-Filled Trapezoidal Enclosure Heated from Below
Md. Mahafujur Rahaman, Sidhartha Bhowmick, Rabindra Nath Mondal, Suvash C. Saha
February 21, 2023 (v1)
Keywords: heat transfer, natural convection, stratified air, transient flow, trapezoidal cavity
Natural convection is intensively explored, especially in a valley-shaped trapezoidal enclosure, because of its broad presence in both technical settings and nature. This study deals with a trapezoidal cavity, which is initially filled with linearly stratified air. Although the sidewalls remain adiabatic, the bottom wall is heated, and the top wall is cooled. For the stratified fluid (air), the temperature of the fluid adjacent to the top and the bottom walls is the same as that of the walls. Natural convection in the trapezoidal cavity is simulated in two dimensions using numerical simulations, by varying Rayleigh numbers (Ra) from 100 to 108 with constant Prandtl number, Pr = 0.71, and aspect ratio, A = 0.5. The numerical results demonstrate that the development of natural convection from the beginning is dependent on the Rayleigh numbers. According to numerical results, the development of transient flow within the enclosure owing to the predefined conditions for the boundary may be... [more]
Modeling and Simulation Research of Interactive Public Opinion Evolution under Multi-Agent Interventions
Hua Chen, Xinquan Zhao
February 21, 2023 (v1)
Keywords: assignment simulation, complex networks, control strategy, interactive public opinion, multi-agent intervention
To study the interactive impact and multi-agent intervention effect caused by multiple public opinion events, a SI3R interactive public opinion communication model is proposed in this paper. Based on interactive public opinion evolution and influence paths of multi-agent interventions, the dynamic equation under multi-agent intervention is formulated; the equilibrium points of the model are calculated and the stability of the model is validated; and the assignment functions are constructed. Further, real data of the case study are obtained and set as initial model simulation parameters, the multi-agent intervention and control measures are numerically simulated and the effects of comprehensive public opinion control are obtained and put forward to suggestions for public opinion management. Simulation results show that the model can simulate the interactive propagation and evolution trend of multiple public opinion events, and imitate the intervention effect of each agent. Compared with... [more]
Comparison of Different Approaches to the Creation of a Mathematical Model of Melt Temperature in an LD Converter
Marek Laciak, Ján Kačur, Ján Terpák, Milan Durdán, Patrik Flegner
February 21, 2023 (v1)
Keywords: LD converter, machine learning methods, mathematical model, steelmaking process, temperature
In the steel production process in the LD converter, it is important to have information about the melt temperature. The temperature and chemical composition of the steel are important parameters in this process in terms of its completion. During the process, continuous measurement of the melt temperature and thus also information about the end of the process are missing. This paper describes three approaches to creating a mathematical model of melt temperature. The first approach is a regression model, which predicts an immeasurable melt temperature based on other directly measured process variables. The second approach to creating a mathematical model is based on the machine learning method. Simple and efficient learning algorithms characterize the machine learning methods. We used support vector regression (SVR) method and the adaptive neuro-fuzzy inference system (ANFIS) to create a mathematical model of the melt temperature. The third approach is the deterministic approach, which... [more]
Application of Data Envelopment Analysis in the Ventilation and Cooling Efficiency Evaluation of Hot Development Headings
Song Xin, Xuefei Han, Sasa Li, Yue Xiao, Wenyu Yang
February 21, 2023 (v1)
Keywords: cooling efficiency, data envelopment analysis, development heading, numerical simulation, ventilation efficiency
The thermal environment of the development headings in deep underground mines tends to be harsh. The design of a reliable auxiliary ventilation system is an important strategy to maintain the thermal environment and air quality in the workplace. Hence, it is of great significance to comprehensively evaluate the effects of different air supply conditions and explore the optimal solution for the auxiliary ventilation system. In this study, cooling efficiency (CE) and ventilation efficiency (VE), which are the two most widely used indices for evaluating the ventilation in public places, were introduced into the field of underground mine ventilation. Numerical simulations of multiple air supply conditions were carried out to obtain the CE and VE, respectively. A data envelopment analysis model was used innovatively to evaluate and rank the efficiency of the different conditions. In the evaluation model, the air supply temperature and air supply velocity were the inputs, whereas CE and VE w... [more]
Special Issue: Mathematical Modeling and Control of Bioprocesses
Philippe Bogaerts, Alain Vande Wouwer
February 21, 2023 (v1)
This Special Issue (SI) of Processes on Mathematical Modeling and Control of Bioprocesses (MMCB) contains papers focusing, on the one hand, on mathematical modeling of biological processes at different scales ranging from microscopic to macroscopic levels and, on the other hand, on model-based estimation, optimization and control of these processes [...]
The Influence of Rotating Speed on the Sealing Characteristics of a Liquid-Sealing Impeller for a Liquid Oxygen Turbopump
Suguo Zhuang, Haifeng Bao, Zhoufeng He, Kai Wang, Houlin Liu
February 21, 2023 (v1)
Keywords: liquid oxygen turbopump, liquid-sealing impeller, numerical simulation, pressurization coefficient, rotating speed, sealing characteristics
In order to explore the influence of rotating speed on the internal flow and sealing characteristics of the liquid-sealing impeller for a liquid oxygen turbopump of a rocket engine, unsteady numerical simulations of the flow characteristics and sealing performance of the first-stage liquid-sealing impeller for a liquid oxygen turbopump under liquid phase conditions were performed. The results show that the pressurization value increases with the increase in the rotating speed. The first-stage liquid-sealing impeller, whose structure is symmetrically distributed along the center of the rotation axis, tends to be an isobaric seal at a rotating speed of 12,000 rpm, and when the rotating speed is decreased or increased, it enters the leakage state or negative pressure sealing state, respectively. The matching relationship between the rotating speed and inlet pressure has a significant effect on the pressurization value, pressurization coefficient and leakage flow rate. Under the working co... [more]
An Effective and Secure Mechanism for Phishing Attacks Using a Machine Learning Approach
Gori Mohamed, J. Visumathi, Miroslav Mahdal, Jose Anand, Muniyandy Elangovan
February 21, 2023 (v1)
Keywords: attack detection, heuristic analysis, machine learning classification, phishing, web crawler
Phishing is one of the biggest crimes in the world and involves the theft of the user’s sensitive data. Usually, phishing websites target individuals’ websites, organizations, sites for cloud storage, and government websites. Most users, while surfing the internet, are unaware of phishing attacks. Many existing phishing approaches have failed in providing a useful way to the issues facing e-mails attacks. Currently, hardware-based phishing approaches are used to face software attacks. Due to the rise in these kinds of problems, the proposed work focused on a three-stage phishing series attack for precisely detecting the problems in a content-based manner as a phishing attack mechanism. There were three input values—uniform resource locators and traffic and web content based on features of a phishing attack and non-attack of phishing website technique features. To implement the proposed phishing attack mechanism, a dataset is collected from recent phishing cases. It was found that real... [more]
Opening and Closing Positioning Control of the Seedling Picking-Up Mechanism Based on Fuzzy-PID Control Algorithm
Shuai Han, Weibing Wang, Yu Wang, Ganghui Liu
February 21, 2023 (v1)
Keywords: closed-loop control, fuzzy PID algorithm, seedling-picking mechanism, simulation analysis, transplanter
The success rate of automatic transplanter seedling picking is affected by the harsh operating environment of the transplanter and the reduced output accuracy of the opening and closing positioning of the seedling-picking mechanism due to the interference of the external environment. To solve such problems, the paper proposes to use an adaptive fuzzy PID control algorithm as the opening and closing positioning-control system of the seedling-picking mechanism. Based on the theoretical analysis and calculation of the positioning accuracy of the seedling-picking mechanism, a mathematical model of stepper motor angular velocity control was established, and a stepper motor angular velocity control model based on fuzzy PID (conventional PID) control was established in MATLAB/Simulink. In order to further simulate the actual working condition of the seedling-picking mechanism, a simulation model of stepper motor control with disturbance was built, and the response results showed that the fuzz... [more]
Network Characteristic Control of Social Dilemmas in a Public Good Game: Numerical Simulation of Agent-Based Nonlinear Dynamics
Chulwook Park
February 21, 2023 (v1)
Keywords: cultural evolution, game theory, public good game, random network, replicator dynamics
This paper proposes a possible mechanism for obtaining sizeable behavioral structures by simulating a network−agent dynamic on an evolutionary public good game with available social .learning. The model considers a population with a fixed number of players. In each round, the chosen players may contribute part of their value to a common pool. Then, each player may imitate the strategy of another player based on relative payoffs (whoever has the lower payoff adopts the strategy of the other player) and change his or her strategy using different exploratory variables. Relative payoffs are subject to incentives, including participation costs, but may also be subject to mutation, whose rate is sensitized by the network characteristics (social ties). The process discussed in this report is interesting and relevant across a broad range of disciplines that use game theory, including cultural evolutionary dynamics.
Experimental and Numerical Study on the Dynamic and Flow Characteristics of a Reciprocating Pump Valve
Ran Li, Wenshu Wei, Hao Liu, Jian Ye, Dalong Wang, Shoubin Li, Wei Wang
February 21, 2023 (v1)
Keywords: Computational Fluid Dynamics, high-speed camera, LVDT, reciprocating pump, U-Adolph theory, valve motion, visualization test
The structure and dynamics of a reciprocating pump liquid end affect the volumetric efficiency and net positive suction head. To match the kinematics with theoretical parameters, reciprocating pump valve motion and flow visualization tests and computational fluid dynamics (CFD) analyses were performed on a wing-guided bevel discharge valve in a horizontal quintuple single-acting reciprocating pump. The valve motion test results showed that the maximum pump valve displacement and the pump valve opening and closing durations were approximately 8.3 mm, 29 ms, and 38 ms, respectively. The corresponding flow visualization test results were 11.4 mm, 9.5 ms, and 35.5 ms. The valve closing durations obtained from the valve motion and flow visualization tests are approximately twice as high as the U-Adolph prediction. The maximum displacement obtained from the valve motion test is consistent with the U-Adolph prediction. Three-dimensional CFD analyses were performed to investigate the flow stat... [more]
Simulation of the Biofiltration of Sulfur Compounds: Effect of the Partition Coefficients
Javier Silva, Rodrigo Ortiz-Soto, Marcelo León, Marjorie Morales, Germán Aroca
February 21, 2023 (v1)
Keywords: activity coefficient, biotrickling filter, culture medium, Modelling, partition coefficient
The effect of the partition coefficient on the simulation of the operation of a biotrickling filter treating a mixture of sulfur compounds was analyzed to evaluate the pertinence of using Henry’s law in determining its removal capacity. The analysis consisted of the simulation of a biotrickling filter that bio-oxides hydrogen sulfide (H2S), dimethyl sulfide (DMS), methyl mercaptan (MM) and dimethyl disulfide (DMDS) using different types of models for determining the partition coefficient: Henry’s law for pure water, Henry’s law adjusted from experimental data, a mixed model (Extended UNIQUAC) and a semi-empirical model of two-parameters. The simulations were compared with experimental data. It was observed that Henry’s law for pure water could produce significant deviations from empirical data due to the liquid phase not being pure water. The two-parameter model better fits with similar results compared to the extended UNIQUAC model, with a lower calculation cost and necessary paramete... [more]
Simple Particle Relaxation Modeling in One-Dimensional Oscillating Flows
Stefan Heidinger, Simon Unz, Michael Beckmann
February 21, 2023 (v1)
Keywords: Basset, drag models, Landau & Lifshitz, one-dimensional, oscillating flow, particles, Schiller & Naumann, spheres, Stokes, ϵ-Re plane
The relaxation of a rigid particle suspended in a one-dimensional oscillating flow is calculated according to different drag models and the results are compared. Conditions are derived under which relaxation can be neglected or drag models can be substituted by simpler ones. This investigation is conducted analytically and graphically via the plane defined by the Reynolds number and amplitude parameter. This work matches various, mostly analytic drag models together to consider simple particle relaxation with a few, broad range input parameters and cover large parts of the plane spanned by Reynolds number and amplitude parameter.
Parametric Sensitivity Analysis and Performance Evaluation of High-Temperature Anion-Exchange Membrane Fuel Cell
Mehdi Mehrtash
February 21, 2023 (v1)
Keywords: 3D modeling, Fuel Cells, high temperature, HT-AEMFC, local current density distribution, relative humidity
In this paper, a three-dimensional model of a high-temperature anion-exchange membrane fuel cell (HT-AEMFC) operating at 110 °C is presented. All major transport phenomena along with the electrochemical reactions that occur in the cell are modeled. Since the water is exclusively in the form of steam and there is no phase transition to deal with in the cell, the water management is greatly simplified. The cell performance under various current loads is evaluated, and the results are validated against the experimental data. The cell performance is examined across a range of operating conditions, including cell temperature, inlet flow rate, and inlet relative humidity (RH). The critical link between the local distributions of species and local current densities along the channels is identified. The distribution of reactants continuously drops in the gas flow direction along the flow channels, causing a non-uniform local current distribution that becomes more pronounced at high current loa... [more]
Unsaturated Hydraulic Conductivity Estimation—A Case Study Modelling the Soil-Atmospheric Boundary Interaction
Md Rajibul Karim, David Hughes, Md Mizanur Rahman
February 21, 2023 (v1)
Keywords: alternative method, hydraulic conductivity, numerical analyses, pore water pressure, unsaturated soil
Pore water pressure changes due to soil-atmospheric boundary interaction can significantly influence soil behaviour and can negatively affect the safety and stability of geotechnical structures. For example, prolonged rainfall events can lead to increased pore water pressure and lower strength; repeated cycles of pore water pressure changes can lead to degradation of strength. These effects are likely to become more severe in the future due to climate change in many parts of the world. To analyse the behaviour of soil subjected to atmospheric boundary interactions, several parameters are needed, and hydraulic conductivity is one of the more important and is difficult to determine. Hydraulic conductivity deduced from laboratory tests are often different from those from the field tests, sometimes by orders of magnitude. The problem becomes even more complicated when the soil state is unsaturated, where the hydraulic conductivity varies with the soil’s state of saturation. In this paper,... [more]
Detection and Isolation of False Data Injection Attack in Intelligent Transportation System via Robust State Observer
Xianhua Huang, Xinyu Wang
February 21, 2023 (v1)
Keywords: detection, false data injection attack, intelligent transportation system, isolation, robust state observer
As the future of transportation systems, the intelligent transportation system is a promising technology to improve the increasingly serious traffic problems. However, the integration of cyber-physical systems makes them vulnerable to new cyber−physical attacks. To ensure the security of intelligent transportation systems, a novel robust state observer-based detection and isolation method against false data injection attacks is developed. Based on the constructed dynamic model of intelligent vehicle networking, the covert characteristic of a false data injection attack is analyzed. Then, a novel state residuals-based detection criterion is developed by using a real-time observed state. To shorten the detection time, an adaptive detection threshold is designed to replace the existing computed threshold. In addition, robust state observer banks are established to isolate multiple injected attacks. Finally, simulation results on the vehicle networking system demonstrate the effectiveness... [more]
Numerical Simulation Investigation on Fracture Propagation of Fracturing for Crossing Coal Seam Roof
Yanchao Li, Jianfeng Xiao, Yixuan Wang, Cai Deng
February 21, 2023 (v1)
Keywords: effective area, effective area ratio, fracture penetration, fracturing through coal seam roof, geological conditions
The fracturing crossing coal seam roof is a technology that fulfills the fracturing of a coal seam through the vertical propagation of fractures. Geological conditions are the key factors determining the effect of this kind of fracturing, but there is hardly any research on this aspect. To determine the favorable geological conditions for through-roof fracturing, based on a 3D fracture propagation model, and considering the interlayer vertical fracture toughness and leak-off heterogeneity, a mathematical model of fracturing through a horizontal well in a coal seam roof was established, and the calculation method of fractures crossing layer propagation was determined. In this method, the effect of fracture communication with the coal seam is evaluated by taking the area and the area ratio of fractures in the coal seam as the objective functions. The effects of parameters such as in situ stress combination profile, coal seam fracture toughness, and fluid loss coefficient on fracturing re... [more]
Description Logic Ontology-Supported Part Orientation for Fused Deposition Modelling
Meifa Huang, Nan Zheng, Yuchu Qin, Zhemin Tang, Han Zhang, Bing Fan, Ling Qin
February 21, 2023 (v1)
Keywords: additive manufacturing, build orientation determination, description logic ontology, fused deposition modelling, multi-criterion decision-making, triangular facet clustering
Fused deposition modelling (FDM) is well-known as an inexpensive and the most commonly used additive manufacturing process. In FDM, build orientation is one of the critical factors that affect the quality of the printed part. However, the activity of determining a build orientation for an FDM part, i.e., part orientation for FDM, usually relies on the knowledge and experience of domain experts. This necessitates an approach that enables the capture, representation, reasoning, and reuse of the data and knowledge in this activity. In this paper, a description logic (DL) ontology-supported part orientation approach for FDM is presented. Firstly, a set of top-level entities are created to construct a DL ontology for FDM part orientation. Then a DL ontology-supported alternative orientation generation procedure, a DL ontology-supported factor value prediction procedure, and a DL ontology-supported optimal orientation selection procedure are developed successively. After that, the applicatio... [more]
Evaluation of Hydrodynamic Performance of New Random Packing Structure Using CFD
Jia-Lin Kang, Siao-Han Huang, Shi-Shang Jang
February 21, 2023 (v1)
Keywords: CFD simulation, flooding point, helical ring, hydraulic evaluation, random packing
This study demonstrates the use of computational fluid dynamics (CFD) to evaluate the hydraulic properties of a new/complicated random packing structure, including flooding point, interfacial area, and liquid holdup. A standard Raschig ring and an extremely complex helical ring were employed as representative traditional and new structures. The combination of Green-Gauss node-based method with polyhedral meshing was presented to improve the hydraulic predictions. The CFD models were adopted to extend the liquid-to-gas ratio, L/G to the flooding points for hydraulic evaluation. The combination to calculate the gradient is essential for correctly evaluating the hydrodynamics of the complex helical ring. The predicted hydrodynamics for the helical ring were in good agreement with the experimental data. The helical ring has a wider operating range of L/G than the Raschig ring. Furthermore, we observed that the gas-liquid interface changed during the flooding and found that the inverted int... [more]
A Fault-Tolerant and a Reconfigurable Control Framework: Application to a Real Manufacturing System
Imane Tahiri, Alexandre Philippot, Véronique Carré-Ménétrier, Abdelouahed Tajer
February 21, 2023 (v1)
Keywords: control reconfiguration, digital twin, distributed control, fault tolerant control, manufacturing systems, PLC implementation
In this paper, we propose a framework to implement a fault-tolerant and a reconfigurable distributed control approach in programmable logic controller (PLC) for manufacturing systems (MS). The reconfiguration methodology adopted in this paper is based on supervisory control theory (SCT), and it is triggered following sensor fault detection. The lost information about these sensors is replaced by timed information allowing the MS to continue its operations. The switch from a normal behavior to a degraded behavior when a sensor fault appears is ensured by reconfiguration rules. The main objective of our framework is to implement the obtained control into a PLC. To meet this objective, the distributed controllers of the two operating modes as well as the reconfiguration rules are interpreted into different Grafcet models. The implementation of these different models is verified by a checker-model technique before being tested on a digital twin and validated on a real MS.
Numerical Simulation and Experimental Analysis of Dynamic Continuous Operation of Low-Concentration Coalbed-Methane-Mixing Device
Lu Xiao
February 21, 2023 (v1)
Keywords: low concentration coalbed methane, mixing device, numerical simulation, resistance loss, uniformity
The concentration of low-concentration coalbed methane extracted from underground coal mine fluctuates greatly, which does not meet the requirements of intake concentration of coalbed-methane utilization devices. Due to this fluctuation, the coalbed-methane-utilization device cannot maintain stable and safe operation. The gas-mixing device is mainly used in coalbed-methane-utilization systems, providing each with a stable feed gas source with qualified concentration. In order to solve the problems of unsatisfactory uniformity of gas mixing and the large resistance of the existing coalbed-methane-mixing device, the mathematical model of the internal flow of the gas-mixing device is established. The influence of the internal structure of the gas-mixing device on the change in the uniformity of gas mixing and resistance loss is studied by numerical simulation and experiment. When the flow is 7000 Nm3/h, 50,000 Nm3/h and 160,000 Nm3/h, respectively, the spiral structure combination of L-N-... [more]
Numerical Study of Factors Affecting Particle Suction Efficiency of Pick-Up Head of a Regenerative Air Vacuum Sweeper
Jamshid Valiev Fayzullayevich, Gangfeng Tan, Frimpong J. Alex, Yongjia Wu, Philip K. Agyeman
February 21, 2023 (v1)
Keywords: computational fluid dynamics (CFD), discrete particle model (DPM), particle removal starting speed, pick-up head, regenerative air vacuum sweeper, suction efficiency
The influence of variable operational conditions affects the performance of particle collection and separation of a regenerative air vacuum sweeper. Therefore, the purpose of this paper was to numerically investigate the factors affecting the particle suction efficiency of the pick-up head. Using computational fluid dynamics (CFD), a model of an integrated pick-up head was developed based on the particle suction process to evaluate the particle removal performance. The realizable k-ε and discrete particle models were utilized to study the gas flow field and solid particle trajectories. The particle structure, sweeping speed, secondary airflow, pressure drop, and distance between the particle suction port and the road surface, as factors that affect the particle removal efficiency, were investigated. The results indicate that the particle suction efficiency increases with decreasing sweeper speed. Furthermore, the particle overall removal efficiency increased with a reduction in the dis... [more]
Airflow Distributions in a Z Type Centripetal Radial Flow Reactor: Effects of Opening Strategy and Opening Rate
Yuchen Xing, Chuanzhao Zhang, Haoyu Wang, Ziyi Li, Yingshu Liu
February 21, 2023 (v1)
Keywords: opening rate, opening strategy, radial flow reactor, Z-type centripetal
Computational fluid dynamics (CFD) was adopted to investigate the influence of the three-section opening strategy in the Z type centripetal radial flow reactor on the uniformity of the gas flow, which aimed to optimize the opening rate of the reactor. The simulation results showed that as the pore-opening ratio of are 10%, 16% and 29% for three sections from top to bottom of the central channel, the opening rate of the circular channel perforated plate is 10−12%, 21−25% and 30−40% from top to bottom, respectively; the uniformity of the reactor was then achieved. Through the simulation results, it was also found that the change in the opening rate at the center pipe perforated plate had a greater contribution to the gas flow mal-distribution inside the reactor. The contribution of the change in the opening rate of the annular channel perforated plate to the uniformity of the gas flow inside the reactor was smaller than that of the center pipe. Annular channel width should not be smaller... [more]
Efficient Discrete Element Modeling of Particle Dampers
Fabio Biondani, Marco Morandini, Gian Luca Ghiringhelli, Mauro Terraneo, Potito Cordisco
February 21, 2023 (v1)
Keywords: contact stiffness, discrete element method, energy dissipation, GPU computing, particle damping
Particle dampers’ dissipative characteristics can be difficult to predict because of their highly non-linear behavior. The application of such devices in deformable vibrating systems can require extensive experimental and numerical analyses; therefore, improving the efficiency when simulating particle dampers would help in this regard. Two techniques often proposed to speed up the simulation, namely the adoption of a simplified frictional moment and the reduction of the contact stiffness, are considered; their effect on the simulation run-time, on the ability of the particle bed to sustain shear deformation, and on the prediction of the dissipation performance is investigated for different numerical case studies. The reduction in contact stiffness is studied in relation to the maximum overlap between particles, as well as the contacts’ duration. These numerical simulations are carried out over a wide range of motion regimes, frequencies, and amplitude levels. Experimental results are c... [more]
Intensification Insights from Chemical Looping Combustion Using Coal−Biomass Mixtures with Fe-Based Oxygen Carrier
Mayur D. Kevat, Tamal Banerjee
February 21, 2023 (v1)
Keywords: Aspen Plus, carbon capture efficiency, CLC, coal/biomass
Chemical looping combustion (CLC) is a modern technology that enables the mitigation of the CO2 concentration without any expense of energy. Experimental evidence shows that combustion of coal/biomass in CLC technology leads to negative carbon emission by replacing the portion of coal with biomass. In the present work, CLC was simulated using a mixture of coal/biomass in CLC; using their different proportions resulted in enhanced CO and CO2 fractions in the fuel reactor. The carbon capture and oxide oxygen fraction were also found to increase with the enhancement of the fuel reactor’s temperature with different proportions of coal/biomass. Increases in the carbon capture efficiency and oxide oxygen fraction of up to 98.86% and ~98%, respectively, were observed within the experimental temperature range. The simulated results of various parameters were predicted and validated with the published experimental results. The stated parameters were also predicted as a function of the different... [more]
A CFD Investigation on the Aerosol Drug Delivery in the Mouth−Throat Airway Using a Pressurized Metered-Dose Inhaler Device
Farnia Dastoorian, Leila Pakzad, Janusz Kozinski, Ehsan Behzadfar
February 21, 2023 (v1)
Keywords: aerosol plume, Computational Fluid Dynamics, cone angle, mouth–throat geometry, particle deposition, pressurized metered-dose inhaler
Inhalation therapy involving a pressurized metered-dose inhaler (pMDI) is one of the most commonly used and effective treatment methods for patients with asthma. The purpose of this study was to develop a computational fluid dynamics (CFD) model to characterize aerosol flow issued from a pMDI into a simulated mouth−throat geometry. The effects of air flow rate and cone angle were analyzed in detail. The behaviour of the multiphase flow initiated at the inhaler actuation nozzle and extended through the mouth−throat airway was simulated based on the Eulerian-Lagrangian discrete phase model, with the k-ω model applied for turbulency. We validated our model against published experimental measurements and cover the hydrodynamic aspect of the study. The recirculation we observed at the 90° bend inside the mouth−throat airway resulted in the selective retention of larger diameter particles, and the fluid flow patterns were correlated with drug deposition behaviour. Enhancing air flow rates up... [more]
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