Effective immune surveillance depends on the continuous trafficking of CD8+ T cells between the circulation, lymphoid organs, and peripheral tissues. Although this homeostatic recirculation is well characterized, less is known about how these trafficking patterns change following immunization and T cell activation. In particular, it remains unclear whether immunization primarily alters trafficking locally within draining lymph nodes or produces broader changes in systemic recirculation, and whether naive and activated CD8+ T cells respond similarly. Here, we extended a previously validated stochastic model of naive CD8+ T cell recirculation in naive mice to naive and pre-activated OT-I CD8+ T cells co-transferred into mice that had been immunized with an attenuated strain of Toxoplasma gondii. Our previous work offered a set of migration parameters at homeostasis baseline that were initially applied to the immunized-host data. To accurately fit the recirculation data of naive T cells i... [more]