Reducing the embodied and operational energy of buildings is a key priority for construction and real estate sectors. It is essential to prioritize materials and construction technologies with low carbon footprints for the design of new buildings. Off-site constructions systems are claimed to have the potential to deliver a low carbon build environment, but at present there are a lack of data about their real environmental impacts. This paper sheds lights on the environmental performance of two offsite technologies: cold formed steel and cross laminated timber. Specifically, the environmental impacts of a CFS technology are discussed according to six standard impact categories, which includes the global warming potential and the total use of primary energy. The study is based on a detailed cradle to gate life cycle analysis of a real case study, and discusses the impacts of both structural and non-structural components of CFS constructions. As a useful frame of reference, this work compares the environmental impacts of 1 m2 of walls and floors of CFS technology with those of cross laminated timber, which is spreading as innovative off-site technology for the development of nearly zero energy buildings, and a conventional reinforced masonry technology, which is largely adopted in the Italian construction sector. The paper concludes with the necessity to optimize structural systems to reduce the overall embodied carbon impacts.