In developing countries, electrification in remote areas, where access to energy is limited or null, has been one of the biggest challenges in recent years. Isolated microgrids with renewable generation are an efficient alternative for the energy supply in these areas. The objective of this work was to analyse the techno-economic viability of 6 isolated microgrids in different locations in the non-interconnected zone of Colombia, considering different climatic conditions, the availability of renewable resources, the current consumption profile, and a modified profile applying demand-side management. Modelling and simulation were performed considering storage systems based on lithium and lead-acid batteries. The resulting simulations provide the optimal system cost, emissions levels, electricity cost and battery lifetime. This study demonstrates that isolated hybrid microgrids with renewable energy are a feasible alternative to solve access to energy problems, reducing the need for diesel generators and optimizing the use of renewable energies and battery-based storage systems.