Mixed Integer Linear Programming (MILP) optimization algorithms provide accurate and clear solutions for Microgrid and Distributed Energy Resources projects. Full-scale optimization approaches optimize all time-steps of data sets (e.g., 8760 time-step and higher resolutions), incurring extreme and unpredictable run-times, often prohibiting such approaches for effective Microgrid designs. To reduce run-times down-sampling approaches exist. Given that the literature evaluates the full-scale and down-sampling approaches only for limited numbers of case studies, there is a lack of a more comprehensive study involving multiple Microgrids. This paper closes this gap by comparing results and run-times of a full-scale 8760 h time-series MILP to a peak preserving day-type MILP for 13 real Microgrid projects. The day-type approach reduces the computational time between 85% and almost 100% (from 2 h computational time to less than 1 min). At the same time the day-type approach keeps the objective function (OF) differences below 1.5% for 77% of the Microgrids. The other cases show OF differences between 6% and 13%, which can be reduced to 1.5% or less by applying a two-stage hybrid approach that designs the Microgrid based on down-sampled data and then performs a full-scale dispatch algorithm. This two stage approach results in 20−99% run-time savings.