Grid-powered pumping plants are widespread electromechanical systems commonly set in motion by electrical machines. The productivity of these electromechanical systems varies substantially according to the shift of the location of the working point on the H-Q plane, which is determined with the help of mutual positions of the characteristics of the pump unit itself and the hydraulic parameters of the pipeline. The topic of the proposed article is mainly focused on the investigation of pumping plant productivity equipped with two various types of electrical machines known as induction and synchronous reluctance motors. A simulation method of efficiency prediction of a centrifugal pumping plant for flow regulation is proposed. The described Simulink/Matlab simulation approach is quite valuable for validating efficiency in the case of pumping plants supplied with various types of electrical machines. The data relating to the electrical machines’ efficiency estimation were obtained during a series of experimental tests with the real experimental setup. Thus, the calculation results of the model are accurate and based on confirmed experimental measurements.