In recent years, lithologic oil and gas reservoirs have become an important target in continental hydrocarbon-bearing basins. Geophysical prospecting technology using seismic data is an indispensable tool for oil and gas exploration. However, while previous work has paid much attention to the seismic responses of reservoirs (sandstones), the seismic responses of depositional sequences composed of sandstone−mudstone cycles are not well understood in reservoir prediction. This problem seriously restricts efficient oil−gas exploration and development. The Cretaceous Baxigai Formation in the Yingmaili area, west of the Tabei Uplift, is an important exploration target for lithologic oil and gas reservoirs in the Tarim Basin. The Baxigai Formation is deeply buried with thin thickness. The Baxigai Formation in the study area is divided into a lower sandstone section and an upper mudstone section. Braided river delta sand bodies are developed in the lower sandstone section, and braided river delta sand bodies and beach bar sand bodies are developed in the upper mudstone section. According to the difference in the depositional sequences in different zones, five types of the vertical combination style of sandstone and mudstone were identified. Through seismic forward modeling, the seismic response variance of the five kinds of sequence models was established. Then, the amplitude attributes were extracted via wavelet decomposition to reflect the distribution of sandstone−mudstone in different zones. This could help predict the vertical and horizontal distributions of different depositional sequences and the sandstones in these sequences. During the sedimentary period of the upper mudstone section of the Baxigai Formation, the beach bar sand bodies were distributed along the northeast coast. The thin sand bodies pinched out along the up-dip direction to form favorable lithologic traps, which has important significance for lithologic reservoir exploration.