Supercritical boilers have become a major development trend in coal-fired power plants, and the air distribution strategy is a key factor in the design and operation of making it fully combustible. In this paper, the mathematical and physical models of a 350 MW supercritical boiler is established, and the optimal air distribution mode of the boiler at different load is determined based on the furnace outlet temperature, NOx concentration, and O2 content. The air distribution control strategies were derived and the corresponding procedures were established. 160 MW and 280 MW were selected for positive pagoda and 180 MW and 230 MW for waist reduced. At 290−350 MW load, the effect of adjusting the combustion damper opening on the outlet oxygen is weak, so preferentially adjusting the SOFA damper opening can achieve better results. The results show good thermal efficiency and emission performance and are applicable to adjust the air distribution mode to achieve fuller combustion of supercritical boilers.