Nanocellulose (NC) is an emerging natural material that offers great potential for various applications due to its unique properties and renewable character. Nowadays, as NC production technologies are advancing, it is essential to evaluate their economic feasibility, technological maturity and commercialization potential using systematic techno-economic analysis (TEA). The present study considers both technical and economic aspects of NC production and analyzes them in two ways: first, by developing a new concept based on the production of different types of NC through the conversion of lignocellulosic biomass by chemical and mechanical technologies, and second, by a comparative review of existing TEA studies in the open literature. Three specific scenarios and two case studies are evaluated by comparing specific key performance indicators (KPIs), such as the production cost (PC) and minimum product selling price (MPSP) of NC. As a result, a short though comprehensive overview of the current state of NC production is provided, highlighting the main technical and economic challenges associated with it. Key areas for future research and innovation (R&I) are also identified to optimize the production processes and reduce relevant costs, in order to make NC competitive with existing materials and realize its full potential.