Currently, China is the largest consumer of titanium (Ti), yet the development of its Ti industry is limited by numerous factors, such as industrial structure imbalance. This study aimed to evaluate the security of China’s Ti industry from 2010 to 2020, seeking to identify relevant issues and propose policy strategies. Firstly, a comprehensive evaluation system for Ti industry security was established, encompassing aspects of availability, economics, and sustainability. Secondly, the entropy weight technique for order preference by similarity to an ideal solution (TOPSIS) combination method and gray correlation method were employed to assess the safety level of China’s Ti industry chain in each year from 2010 to 2020. Additionally, the coupling degree and sensitivity were used to analyze the dimension layers and index system to determine those that negatively impact the safety level of the Ti industry chain. The analysis results reveal that the economic level exerts a significant influence on the development of the Ti industry. Accordingly, under the same level of change, while considering availability, equal attention should be provided to economic considerations for a well-rounded evaluation of the industry’s safety level.