In order to explore the rules between gravity anomalies and oil-gas distribution characteristics in central and western Sichuan Basin, we divided the tectonic unit in central and western Sichuan basin on the base of the analysis of gravity anomaly characteristics, and studied the correlation between the oil−gas distribution and the local gravity anomaly in the study area. The results show that the variation in the range of the Bouguer gravity field in the interior of the basin is relatively small, and the southern part shows a clear gravity high zone, with gradual gravity gradient zones all around the basin periphery. The abnormal value of the residual gravity field in the basin is an obvious high−value gravity belt in the north and west, and the interior is arranged alternately with local high gravity and low gravity in the north−east direction. The tectonic units of the central and western Sichuan Basin can be divided into five regions, based on the characteristics of the Bouguer gravity field, namely, the Central Sichuan uplift zone, the West Sichuan depressional zone, the East Sichuan high steep zone, the South Sichuan low steep zone, and the North Sichuan low slow zone. Combined with geological data and Bouguer gravity anomaly processing results, the distribution of oil and gas fields in the central and western Sichuan Basin is certain correlated with the local gravity high zone and the transition zone between the local gravity high zone and the local gravity low zone. They are the major areas of oil and gas.