The present study experimentally and numerically investigates the effect of channel height on the flow and heat transfer characteristics of a channel impingement cooling configuration for various jet Reynolds numbers in the range of 2000−8600. A single array consisting of eleven jets with 0.8 mm diameter injects water into the channel with 2 mm width at four different channel heights (3, 4, 5, and 6 mm). The average heat transfer coefficients at the target surface are measured by maintaining a temperature difference between the jet exit and the target surface in the range of 15−17 °C for each channel height. The experimental results show the average heat transfer coefficient at the target surface increases with the jet Reynolds number and decreases with the channel height. An average Nusselt number correlation is developed based on 85 experimentally measured data points with a mean absolute error of less than 4.31%. The numerical simulation accurately predicts the overall heat transfer rate within 10% error. The numerical results are analyzed to investigate the flow structure and its effect on the local heat transfer characteristics. The present study advances the primary understanding of the flow and heat transfer characteristics of the channel impingement cooling configuration with liquid jets.