Turbomachinery with double counter-rotating impellers offers more degrees of freedom in the choice of design and control parameters compared to conventional machines. For these innovative machines, the literature review shows that more publications concerning axial type turbomachines are available than centrifugal ones. This work deals with a design and experimental performance analysis, applied to two counter-rotating impellers of a centrifugal compressor “CRCC”. CRCC was designed with a specifically developed tool based on mean-line approach coupled with optimization algorithms and a stream-curvature through-flow method to satisfy the design criteria. This paper presents an experimental validation of the CRCC design tool and its performances against the baseline “SR”, composed of one centrifugal impeller and a volute for which experimental data are available. CRCC numeric simulations are also validated by experimental data. For a fair comparison between CRCC and SR, the same volute is used for both configurations. The CRCC studied here includes a first conventional impeller with an axial inlet and a radial outlet, while the second impeller is parametrically designed and can be considered a rotating bladed diffuser with a radial inlet and outlet. The obtained results show that CRCC can deliver a pressure rise increase of two compared to SR, along with an increase of isentropic efficiency and also validate the design method of this novel layout. The experimental results also show that the speed ratio of CRCC has a positive effect on the surge and shock margin.