This study focuses on analyzing the turbulent flow of drilling fluid in inclined wells using the Computational Fluid Dynamics (CFD) technique. The analysis is performed considering an annulus with a fixed eccentricity of 90% and varying fluid properties, diameter ratio, and bed thickness to examine velocity profile, pressure loss, and overall wall and average bed shear stresses. CFD simulation results are compared with existing data for validation. The pressure loss predicted with CFD agrees with the data. After verification, predictions are used to establish a correlation that can be applied to compute bed shear stress. The established correlation mostly displays a discrepancy of up to 10% when compared with simulation data. The correlation can be used to optimize hole cleaning and manage downhole pressure.