In this article, the research object is the solar domestic hot water (SDHW) heating system that has been in operation since 2015 and is located on the campus of the Bialystok University of Technology (Poland). The thermal performance of solar collectors are thoroughly investigated so far. Therefore, special attention was paid to the issue of the heat loss from pipes. The measurements showed that the heat transfer in circulation pipes is quite complex due to continuous fluctuations in water temperature at the supply of this loop. As it turned out, the application of the classical method of energy balancing and the readings from heat meters gave inaccurate results in this case. The main aim of this study was to develop a different approach to solving the problem of determination of heat losses. The method presented in this article is based on computational fluid dynamics (CFD) and measurement results as the input data. The practical result of this study was the development of two relationships for calculating the heat loss from pipes. A separate issue, that is discussed in this paper, concerns the impact of the time intervals used in numerical simulations on the accuracy of calculation results.