This paper evaluates the potential energy savings when switchable insulation systems (SIS) are applied to walls of residential buildings located in Belgium and other locations in Europe. The study considers two low-energy prototypical dwellings (an apartment and a detached house) that are representative of post-2010 constructions and renovations in Belgium. Using an 3R2C-based analysis tool, the performance of both dwellings is evaluated with static and dynamic wall insulation systems. First, the switchable insulating system is described along with its associated simple 2-step rule-based control strategy. Then the modeling strategy and simulation analysis tools are presented. In Belgium, it was found that SIS-integrated walls allow energy savings up to 3.7% for space heating and up to 98% for cooling. Moreover, it was found that to further reduce the energy consumption of SIS-integrated buildings in various European climates, thermal mass placement needs to be considered. By optimizing the placement and the parameters of the various wall layers, it is possible to increase the space heating savings by up to a factor of 4 and those of cooling by up to a factor of 2.5.