Machine learning and data mining techniques are nowadays being used in many business sectors to exploit the data in order to detect trends, discover certain features and patters, or even predict the future. However, in the field of aerodynamics, the application of these techniques is still in the initial stages. This paper focuses on exploring the benefits that machine learning and data mining techniques can offer to aerodynamicists in order to extract knowledge from the CFD data and to make quick predictions of aerodynamic coefficients. For this purpose, three aerodynamic databases (NACA0012 airfoil, RAE2822 airfoil and 3D DPW wing) have been used and results show that machine-learning and data-mining techniques have a huge potential also in this field.