A multistage centrifugal pump was developed for high head and high flow rate applications. A double-suction impeller and a twin-volute were installed at the first stage followed by an impeller, diffuser and return vanes for the next four stages. An initial design feasibility study was conducted using three-dimensional computational fluid dynamics tools to study the performance and the hydraulic losses associated with the design. Substantial losses in head and efficiency were observed at the interface between the first stage volute and the second stage impeller. An inducer-type guide vane (ITGV) was installed at this location to mitigate the losses by reducing the circumferential velocity of the fluid exiting the volute. The ITGV regulated the pre-swirl of the fluid entering the second stage impeller. The pump with and without ITGV is compared at the design flow rate. The pump with ITGV increased the stage head by 63.28% and stage efficiency by 47.17% at the second stage. As a result, the overall performance of the pump increased by 5.78% and 3.94% in head and efficiency, respectively, at the design point. The ITGV has a significant impact on decreasing losses at both design and off-design conditions. An in-depth flow dynamic analysis at the inducer-impeller interface is also presented.