Torrefied empty fruit bunch (EFB) co-firing is a promising technology to reduce emissions from coal-fired power plants. However, co-firing can influence the combustion and heat transfer characteristics in a coal boiler. In order to study the feasibility of co-firing application of torrefied EFB (T-EFB) in boilers, the combustion characteristics, gas emissions and heat flux distribution were analyzed, respectively. First, the kinetic parameters of T-EFB devolatilization and char oxidation were obtained by experimental analysis. Second, the computational fluid dynamics (CFD) analysis was applied to the actual 500 MWe boiler simulation to further evaluate the differences in the co-firing performance parameters (combustion characteristics and emissions) of the T-EFB and the heat transfer characteristics within the boiler. Numerical results show that T-EFB co-firing can improve the ignition characteristics of pulverized coal, reduce the formation of unburned particles. When the blending ratio was increased from 10% to 50%, significantly NOx (oxides of nitrogen) reduction (levels from 170 to 98 ppm at 6% O2) was achieved. At a blending ratio above 40%, boiler combustion efficiency decreases as the total heat flux of the boiler decreases due to an increase in the amount of unburned carbon. In addition, T-EFB co-firing can affect the heat transfer characteristics of the boiler.