A novel interleaved high step-up DC−DC converter applied for applications in photovoltaic systems is proposed in this paper. The proposed configuration is composed of three-winding coupled inductors, voltage multiplier cells and a clamp circuit. The step-up voltage gain is effectively increased, owing to the voltage-stack and voltage-lift techniques using the voltage multiplier cells. The leakage inductor energy is recycled by the clamp circuit to avoid the voltage surge on a power switch. The low-voltage-rated power switches with low on-state resistances and costs can be used to decrease the conduction losses and increase the conversion efficiency when the voltage stresses of power switches for the converter are considerably lower than the high output voltage. The reverse-recovery problems of diodes are mitigated by the leakage inductances of the coupled inductors. Moreover, both the input current ripple and the current stress on each power switch are reduced, owing to the interleaved operation. The operating principle and steady-state analysis of the proposed converter are thoroughly presented herein. A controller network is designed to diminish the effect of the variations of input voltage and output load on the output voltage. Finally, the experimental results for a 1 kW prototype with 28−380 V voltage conversion are shown to demonstrate its effectiveness and performance.