LAPSE:2025.0387v1
Published Article
LAPSE:2025.0387v1
Applying Quality by Design to Digital Twin Supported Scale-Up of Methyl Acetate Synthesis
June 27, 2025
Abstract
A new method for efficient process development is the direct scale-up from laboratory scale to production scale using mechanistic models [1]. The integration of the Quality by Design approach into this scale-up concept may prove beneficial for a variety of product- and process-related aspects. This paper presents a workflow for the digital twin-supported direct scale-up of processes and process plants, which integrates elements of the Quality by Design methodology. To illustrate the concept, the workflow is implemented for the example of an esterification reaction in a stirred tank reactor. Finally, benefits of the implementation of Quality by Design in the direct scale-up using digital twins regarding the product quality and the process development are discussed as well as its limitations.
A new method for efficient process development is the direct scale-up from laboratory scale to production scale using mechanistic models [1]. The integration of the Quality by Design approach into this scale-up concept may prove beneficial for a variety of product- and process-related aspects. This paper presents a workflow for the digital twin-supported direct scale-up of processes and process plants, which integrates elements of the Quality by Design methodology. To illustrate the concept, the workflow is implemented for the example of an esterification reaction in a stirred tank reactor. Finally, benefits of the implementation of Quality by Design in the direct scale-up using digital twins regarding the product quality and the process development are discussed as well as its limitations.
Record ID
Keywords
digital twin, quality by design, scale-up
Subject
Suggested Citation
Ebert J, Koch A, Viedt I, Urbas L. Applying Quality by Design to Digital Twin Supported Scale-Up of Methyl Acetate Synthesis. Systems and Control Transactions 4:1462-1467 (2025) https://doi.org/10.69997/sct.138478
Author Affiliations
Ebert J: Technische Universität Dresden, Process-to-Order Group, Process Systems Engineering
Koch A: Technische Universität Dresden, Process-to-Order Group, Process Systems Engineering; Technische Universität Dresden, Process-to-Order Group, Process-to-Order Lab Learning Factory
Viedt I: Technische Universität Dresden, Process-to-Order Group, Process Systems Engineering; Technische Universität Dresden, Process-to-Order Group, Process-to-Order Lab Learning Factory
Urbas L: Technische Universität Dresden, Process-to-Order Group, Process Systems Engineering; Technische Universität Dresden, Process-to-Order Group, Process-to-Order Lab Learning Factory
Koch A: Technische Universität Dresden, Process-to-Order Group, Process Systems Engineering; Technische Universität Dresden, Process-to-Order Group, Process-to-Order Lab Learning Factory
Viedt I: Technische Universität Dresden, Process-to-Order Group, Process Systems Engineering; Technische Universität Dresden, Process-to-Order Group, Process-to-Order Lab Learning Factory
Urbas L: Technische Universität Dresden, Process-to-Order Group, Process Systems Engineering; Technische Universität Dresden, Process-to-Order Group, Process-to-Order Lab Learning Factory
Journal Name
Systems and Control Transactions
Volume
4
First Page
1462
Last Page
1467
Year
2025
Publication Date
2025-07-01
Version Comments
Original Submission
Other Meta
PII: 1462-1467-1442-SCT-4-2025, Publication Type: Journal Article
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LAPSE:2025.0387v1
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https://doi.org/10.69997/sct.138478
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Jun 27, 2025
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References Cited
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