Model uncertainty creates a largely open challenge for industrial process control, which causes a trade-off between robustness and performance optimality. In such a case, we propose a generalized conditional feedback (GCF) system to largely eliminate conflicts between robustness and performance optimality. This approach leverages a nominal model to design an optimal control in the virtual domain and defines an ancillary feedback controller to drive the physical process to track the trajectory of the virtual domain. The effectiveness of the proposed GCF scheme is demonstrated in a simulation for six typical industrial processes and three model-based control methods, and in a half-quadrotor system control test. Furthermore, the GCF scheme is open to existing optimal control and robust control theories.