Challenges associated with mesophilic digestate (MD) involve volume, odor, and pathogens, which effective post-digestion treatments can address. The efficiency of MD post-treatment can be enhanced by conditioning with ferric chloride (FeCl3), hydrogen peroxide (H2O2), and polymer. This study aimed to observe the effect of combined chemical conditioning on volume reduction, phosphorus (P) release, odor, and pathogen reduction potential for MD. MD was conditioned with polymer only, polymer and FeCl3 at pH adjusted to 8.0 with lime (Ca(OH)2), and a blend of polymer, FeCl3, and hydrogen peroxide (H2O2) at pH 8.0. The results show that adding all three chemicals improved post-treatment efficiency at 2.1 kg/t DS FeCl3, 2.1 kg/t DS polymer, and 600 mg/L H2O2 at pH 8.0, compared with polymer or dual conditioning. At the combined dose, cake solid content, centrate P removal, and odor reduction capability improved compared with raw MD by 20%, 99%, and 66%, respectively. Combined chemical treatment reduced fecal coliform by 98% but does not fulfil class A requirements and showed 50% regrowth potential. The synergic effect of polymer, FeCl3, H2O2, and alkaline pH breakdown EPS, reduced water holding capacity and formed compacted flocs for better water removal and settling. This combination also precipitated P through FeCl3 while H2O2 oxidation curbs odor, enhancing further P removal from centrate.