LAPSE:2023.5437
Published Article
LAPSE:2023.5437
In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein
February 23, 2023
Medicinal plants possess a surplus of novel and biologically active secondary metabolites that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) Sleumer is used to treat mental disorders. The present research was designed to explore phytochemicals from the ethanol leaf extract of Gomphandra tetrandra (Wall.) Sleumer to identify the potential pharmacophore(s) in the treatment of neurological disorders. The chemical compounds of the experimental plant were identified through GC-MS analysis. In-vitro antioxidant activity was assessed using different methods. Furthermore, in-vivo neurological activity was assessed in Swiss-albino mice. Computer-aided analysis was appraised to determine the best-fit phytoconstituent of a total of fifteen identified compounds in the experimental plant extract against beta-amyloid precursor protein. The experimental extract revealed fifteen compounds in GC-MS analysis and the highest content was 9, 12, 15-octadecatrienoic acid (z,z,z). The extract showed potent antioxidant activity in in-vitro assays. Furthermore, in in-vivo neurological assays, the extract disclosed significant (p < 0.05) neurological activity. The most favorable phytochemicals as neurological agents were selected via ADMET profiling, and molecular docking was studied with beta-amyloid precursor protein. In the computer-aided study, 1, 5-diphenyl-2h-1, 2, 4-triazoline-3-thione (Pub Chem CID: 2802516) was more active than other identified compounds with strong binding affinity to beta-amyloid precursor protein. The present in vivo and in silico studies revealed neuropharmacological features of G. tetrandra leaf extract as a natural agent against neurological disorders, especially Alzheimer’s disease.
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Keywords
ADMET profile, Alzheimer’s disease, beta-amyloid precursor protein, GC-MS, molecular docking, neurological activity
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Suggested Citation
Rahman MS, Zilani MNH, Islam MA, Hasan MM, Islam MM, Yasmin F, Biswas P, Hirashima A, Rahman MA, Hasan MN, Kim B. In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein. (2023). LAPSE:2023.5437
Author Affiliations
Rahman MS: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic [ORCID]
Zilani MNH: Department of Pharmacy, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh [ORCID]
Islam MA: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Hasan MM: Department of Pharmacy, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh
Islam MM: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Yasmin F: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Biswas P: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Hirashima A: Laboratory of Pesticide Chemistry, Division of Bio-Science and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
Rahman MA: Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh; Department of Pathology, College of Korean Medicine, Kyung Hee U [ORCID]
Hasan MN: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic [ORCID]
Kim B: Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea [ORCID]
Zilani MNH: Department of Pharmacy, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh [ORCID]
Islam MA: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Hasan MM: Department of Pharmacy, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh
Islam MM: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Yasmin F: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Biswas P: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic
Hirashima A: Laboratory of Pesticide Chemistry, Division of Bio-Science and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
Rahman MA: Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh; Department of Pathology, College of Korean Medicine, Kyung Hee U [ORCID]
Hasan MN: Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh; Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic [ORCID]
Kim B: Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea [ORCID]
Journal Name
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Volume
9
Issue
8
First Page
1449
Year
2021
Publication Date
2021-08-20
Published Version
ISSN
2227-9717
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PII: pr9081449, Publication Type: Journal Article
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LAPSE:2023.5437
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doi:10.3390/pr9081449
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