LAPSE:2023.4812
Published Article
LAPSE:2023.4812
Characterization, Chemical Compounds and Biological Activities of Marrubium vulgare L. Essential Oil
February 23, 2023
Abstract
As consumer trends shift towards more natural and ecological consumption patterns, industrialists are actively working towards substituting synthetic chemicals with natural and vegan products that contain bioactive properties. Thus, considering the shifts in customer demand and the growing concern around vegetable sourced productions, this work aims to contribute to the valorization of aromatic and medicinal Moroccan plants. By focusing on the Marrubium vulgare L. species, our objective is to carry out a physicochemical characterization to determine its chemical composition and biological activities. The volatile fraction collected by hydrodistillation (0.61%) and analyzed by GC-MS (gas chromatography coupled to mass spectrometry) contains five main compounds: 3-Thujanone, Eugenol, Topanol, Menthone and Piperitone. The antioxidant activity has been estimated by applying the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The values of inhibitory concentration prove that our oil is a good antioxidant, with values of IC50 = 1.136 mg/mL and IC50 = 2.998 mg/mL, respectively, for the DPPH and FRAP tests. The results of the antifungal activity indicate a significant inhibition of mycelial growth for both tested molds, as well as a total inhibition of spore production at a concentration of 0.25 µL/mL.
As consumer trends shift towards more natural and ecological consumption patterns, industrialists are actively working towards substituting synthetic chemicals with natural and vegan products that contain bioactive properties. Thus, considering the shifts in customer demand and the growing concern around vegetable sourced productions, this work aims to contribute to the valorization of aromatic and medicinal Moroccan plants. By focusing on the Marrubium vulgare L. species, our objective is to carry out a physicochemical characterization to determine its chemical composition and biological activities. The volatile fraction collected by hydrodistillation (0.61%) and analyzed by GC-MS (gas chromatography coupled to mass spectrometry) contains five main compounds: 3-Thujanone, Eugenol, Topanol, Menthone and Piperitone. The antioxidant activity has been estimated by applying the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging test and the ferric reducing antioxidant power (FRAP). The values of inhibitory concentration prove that our oil is a good antioxidant, with values of IC50 = 1.136 mg/mL and IC50 = 2.998 mg/mL, respectively, for the DPPH and FRAP tests. The results of the antifungal activity indicate a significant inhibition of mycelial growth for both tested molds, as well as a total inhibition of spore production at a concentration of 0.25 µL/mL.
Record ID
Keywords
antifungal, antioxidant, essential oil, GC-MS, Marrubium vulgare L., physicochemical characterization
Suggested Citation
Rached S, Imatara H, Habsaoui A, Mzioud K, Haida S, Saleh A, Al kamaly O, Alahdab A, Parvez MK, Ourras S, El Fartah S. Characterization, Chemical Compounds and Biological Activities of Marrubium vulgare L. Essential Oil. (2023). LAPSE:2023.4812
Author Affiliations
Rached S: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Imatara H: Faculty of Arts and Sciences, Arab American University Palestine, P.O. Box 240, Jenin P227, Palestine [ORCID]
Habsaoui A: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Mzioud K: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Haida S: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Saleh A: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
Al kamaly O: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia [ORCID]
Alahdab A: Institute of Pharmacy, Clinical Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Street 17, 17489 Greifswald, Germany
Parvez MK: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia [ORCID]
Ourras S: Laboratory for Plant, Animal and Agro-Industrial Production, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
El Fartah S: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Imatara H: Faculty of Arts and Sciences, Arab American University Palestine, P.O. Box 240, Jenin P227, Palestine [ORCID]
Habsaoui A: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Mzioud K: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Haida S: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Saleh A: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
Al kamaly O: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia [ORCID]
Alahdab A: Institute of Pharmacy, Clinical Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Street 17, 17489 Greifswald, Germany
Parvez MK: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia [ORCID]
Ourras S: Laboratory for Plant, Animal and Agro-Industrial Production, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
El Fartah S: Laboratory of Advanced Materials and Process Engineering, Faculty of Science, Ibn Tofail University, Kenitra BP.133-14000, Morocco
Journal Name
Processes
Volume
10
Issue
10
First Page
2110
Year
2022
Publication Date
2022-10-18
ISSN
2227-9717
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PII: pr10102110, Publication Type: Journal Article
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LAPSE:2023.4812
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https://doi.org/10.3390/pr10102110
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