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LAPSE:2023.4255

Expression of Selected microRNAs in Migraine: A New Class of Possible Biomarkers of Disease?

Lara Ahmad, Chiara Demartini, Michele Corrado, Gloria Vaghi, Elisa Maria Piella, Marta Allena, Anna Maria Zanaboni, Rosaria Greco, Cristina Tassorelli, Roberto De Icco

February 22, 2023

Abstract
Preliminary but convergent findings suggest a role for microRNAs (miRNAs) in the generation and maintenance of chronic pain and migraine. Initial observations showed that serum levels of miR-382-5p and miR-34a-5p expression were increased in serum during the migraine attack, with miR-382-5p increasing in the interictal phase as well. By contrast, miR-30a-5p levels were lower in migraine patients compared to healthy controls. Of note, antimigraine treatments proved to be capable of influencing the expression of these miRNAs. Altogether, these observations suggest that miRNAs may represent migraine biomarkers, but several points are yet to be elucidated. A major concern is that these miRNAs are altered in a broad spectrum of painful and non-painful conditions, and thus it is not possible to consider them as truly “migraine-specific” biomarkers. We feel that these miRNAs may represent useful tools to uncover and define different phenotypes across the migraine spectrum with different treatment susceptibilities and clinical features, although further studies are needed to confirm our hypothesis. In this narrative review we provide an update and a critical analysis of available data on miRNAs and migraines in order to propose possible interpretations. Our main objective is to stimulate research in an area that holds promise when it comes to providing reliable biomarkers for theoretical and practical scientific advances.

Record ID

LAPSE:2023.4255

Keywords

biomarker, CGRP, headache, miRNA, pain

Subject

Food & Agricultural Processes

Suggested Citation

Ahmad L, Demartini C, Corrado M, Vaghi G, Piella EM, Allena M, Zanaboni AM, Greco R, Tassorelli C, De Icco R. Expression of Selected microRNAs in Migraine: A New Class of Possible Biomarkers of Disease?. (2023). LAPSE:2023.4255

Author Affiliations

Ahmad L: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
Demartini C: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy [ORCID]
Corrado M: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy [ORCID]
Vaghi G: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
Piella EM: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
Allena M: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy
Zanaboni AM: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
Greco R: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy
Tassorelli C: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
De Icco R: Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, 27100 Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy [ORCID]

Journal Name

Processes

Volume

Issue

First Page

2199

Year

2021

Publication Date

2021-12-06

DOI:

https://doi.org/10.3390/pr9122199