The understanding of the impact of buoyancy-driven flow on the migration of respiratory droplets remains limited. To investigate this phenomenon, the Lagrangian−Eulerian approach (k-ε turbulent model and discrete phase model) was employed to analyze the interaction between buoyancy-driven flow and coughing activity. The simulation approach was validated by simulating a jet problem in water. Although this problem describes the jet penetration in water, the governing equations for this problem are the same as those for coughing activity in the air. The results demonstrated that an umbrella-shaped airflow was generated above a person and a temperature stratification existed in the room. The buoyancy-driven flow significantly altered the dispersion pattern of the droplets. Notably, for large droplets with an initial diameter of 100 μm, the flow in the boundary layer led to an increased deposition time by about five times. Conversely, for small droplets with an initial diameter of 20 μm, the umbrella-shaped airflow resulted in a more rapid dispersion of droplets and subsequently facilitated their quicker removal by the room walls. After a duration of 300 s, the suspended droplet number of the case with buoyancy-driven flow was 33.4% smaller than that of the case without buoyancy-driven flow. Two or three persons being in the room resulted in a faster droplet removal.