LAPSE:2023.36621
Published Article
LAPSE:2023.36621
Peptide Diversification through Addition Reaction of Free Carboxylic Acids to Ynamides
September 20, 2023
Peptide modification has emerged as an important topic in the academic community and pharmaceutical industry. However, they are primarily focused on the diversification of amines, thiols, and alcohols. Direct and chemoselective modification of acid residues in peptides is relatively underdeveloped. In this context, we report a novel and efficient method for the direct functionalization of acid residues in peptides. By using ynamides as reaction partners, the adducts are rapidly obtained in moderate to excellent yields at room temperature in water. This approach shows excellent chemoselectivity and a broad scope including dipeptides bearing unprotected Trp or Tyr residue and free Ser or Gln residue.
Record ID
Keywords
addition reaction, peptide, ynamide
Subject
Suggested Citation
Zhang Z, Cai L, Song L. Peptide Diversification through Addition Reaction of Free Carboxylic Acids to Ynamides. (2023). LAPSE:2023.36621
Author Affiliations
Zhang Z: Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innova
Cai L: Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innova
Song L: Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innova [ORCID]
Cai L: Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innova
Song L: Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innova [ORCID]
Journal Name
Processes
Volume
11
Issue
8
First Page
2262
Year
2023
Publication Date
2023-07-27
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr11082262, Publication Type: Journal Article
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Published Article
LAPSE:2023.36621
This Record
External Link
doi:10.3390/pr11082262
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73
Version History
[v1] (Original Submission)
Sep 20, 2023
Verified by curator on
Sep 20, 2023
This Version Number
v1
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URL Here
https://psecommunity.org/LAPSE:2023.36621
Original Submitter
Calvin Tsay
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