Development of Tea Tree Oil Based Nanoemulgel Loaded with Azithromycin for Enhancing the Antibacterial Activity

Nasrin E. Khalifa; Marwa H. Abdallah; Hanaa A. Elghamry; Weam M. A. Khojali; El-Sayed Khafagy; Hemat El-Sayed El-Horany; Seham Shawky

LAPSE

Living Archive for Process Systems Engineering

LAPSE:2023.36380

Published Article

LAPSE:2023.36380

Development of Tea Tree Oil Based Nanoemulgel Loaded with Azithromycin for Enhancing the Antibacterial Activity

Nasrin E. Khalifa, Marwa H. Abdallah, Hanaa A. Elghamry, Weam M. A. Khojali, El-Sayed Khafagy, Hemat El-Sayed El-Horany, Seham Shawky

July 13, 2023

Azithromycin (AZ) is an azalide macrolide antibiotic that is frequently employed for treating bacterial skin infections. It suffers from limited oral bioavailability, which results from incomplete absorption or extensive first-pass metabolism. Therefore, preparing azithromycin formulations for topical administration is highly recommended to avoid first-pass metabolism and to boost the concentration of the drug on the skin. The objective of our investigation was to formulate and evaluate the efficacy of AZ-loaded nanoemulgel as an antimicrobial drug. The physical appearance, spreadability, viscosity, particle size, in vitro drug release, ex vivo permeation investigations, and antimicrobial efficiency of the prepared formulations were evaluated. The prepared formulation loaded with AZ exhibited good physical quality. AZ-loaded nanoemulgel had a greater ex vivo drug permeation across rabbit skin than other formulations (AZ-loaded gel and AZ-loaded emulgel), revealing improved drug permeation and greater transdermal flux in addition to enhanced antibacterial efficacy (p < 0.05). Overall, our findings imply that tea-tree-oil-based nanoemulgel would be a promising delivery system for enhancing the antimicrobial efficiency of azithromycin.

Record ID

LAPSE:2023.36380

Keywords

anti-bacterial activity, Azithromycin, emulgel, nanoemulgel, tea tree oil

Subject

Biosystems

Suggested Citation

Khalifa NE, Abdallah MH, Elghamry HA, Khojali WMA, Khafagy ES, El-Sayed El-Horany H, Shawky S. Development of Tea Tree Oil Based Nanoemulgel Loaded with Azithromycin for Enhancing the Antibacterial Activity. (2023). LAPSE:2023.36380

Author Affiliations

Khalifa NE: Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum 11115, Sudan [ORCID]
Abdallah MH: Department of Pharmaceutics, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt [ORCID]
Elghamry HA: Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
Khojali WMA: Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha’il, Ha’il 81442, Saudi Arabia; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Omdurman 14415, Sudan
Khafagy ES: Department of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41552, Egypt [ORCID]
El-Sayed El-Horany H: Department of Biochemistry, College of Medicine, University of Ha’il, Ha’il 81442, Saudi Arabia; Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta 31511, Egypt
Shawky S: Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Cairo 11651, Egypt

Journal Name

Processes

Volume

11

Issue

6

First Page

1836

Year

2023

Publication Date

2023-06-17