This study investigates pneumatic conveying of four different biomass materials, namely cottonseeds, wood pellets, wood chips, and wheat straw. The performance of a previously proposed model for predicting pressure drop is evaluated using biomass materials. Results indicate that the model can predict pressure with an error range of 30 percent. To minimize the number of trial tests required, an optimization algorithm is proposed. The findings show that with a combination of three trial tests, there is a 60 percent probability of selecting the right subset for accurately predicting pressure drop for the entire range of tests. Further investigation of different training subsets suggests that increasing the number of tests from 3 to 7 can improve the probability from 60% to 90%. Moreover, thorough analysis of all three-element subsets in the entire series of tests reveals that when considering air mass flow rate as the input, having air mass flow rates that are not only closer in value but also lower increases the likelihood of selecting the correct subset for predicting pressure drop across the entire range. This advancement can help industries to design and optimize pneumatic conveying systems more effectively, leading to significant energy savings and improved operational performance.