LAPSE:2023.36179
Published Article
LAPSE:2023.36179
Residence Time Section Evaluation and Feasibility Studies for One-Column Simulated Moving Bed Processes (1-SMB)
July 4, 2023
The simulated moving bed (SMB) is a well-established, fully continuous process for chromatographic separation of difficult tasks with overlapping peaks, but it is relatively complex. The 1-SMB, which uses only one column but includes residence time zones to preserve concentration profiles, is a simpler semi-continuous alternative. This work examines the possible design of these residence time zones. Simulation studies were conducted to investigate the dependence of process metrics, such as purity, yield, productivity, and eluent consumption, on fluid dynamics. No deterioration in purity was observed, and the other variables remained constant over a wide range of axial dispersion before decreasing sharply. Pilot-scale experiments were conducted with various devices, including coiled flow inverters, eluate recycling devices, packed columns, and tank arrangements, to validate possible apparatus implementations with fluid dynamic measurements. It was demonstrated that the 1-SMB offers similar performance to the 4-SMB, albeit with reduced yield and lower apparatus complexity.
Record ID
Keywords
1-SMB, simulated moving bed
Subject
Suggested Citation
Zobel-Roos S, Vetter F, Strube J. Residence Time Section Evaluation and Feasibility Studies for One-Column Simulated Moving Bed Processes (1-SMB). (2023). LAPSE:2023.36179
Author Affiliations
Zobel-Roos S: Institute for Separation and Process Technology, Clausthal University of Technology, Leibnizstraße 15, D-38678 Clausthal-Zellerfeld, Germany
Vetter F: Institute for Separation and Process Technology, Clausthal University of Technology, Leibnizstraße 15, D-38678 Clausthal-Zellerfeld, Germany
Strube J: Institute for Separation and Process Technology, Clausthal University of Technology, Leibnizstraße 15, D-38678 Clausthal-Zellerfeld, Germany
Vetter F: Institute for Separation and Process Technology, Clausthal University of Technology, Leibnizstraße 15, D-38678 Clausthal-Zellerfeld, Germany
Strube J: Institute for Separation and Process Technology, Clausthal University of Technology, Leibnizstraße 15, D-38678 Clausthal-Zellerfeld, Germany
Journal Name
Processes
Volume
11
Issue
6
First Page
1634
Year
2023
Publication Date
2023-05-26
Published Version
ISSN
2227-9717
Version Comments
Original Submission
Other Meta
PII: pr11061634, Publication Type: Journal Article
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Published Article
LAPSE:2023.36179
This Record
External Link
doi:10.3390/pr11061634
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Version History
[v1] (Original Submission)
Jul 4, 2023
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Jul 4, 2023
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https://psecommunity.org/LAPSE:2023.36179
Original Submitter
Calvin Tsay
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